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Harmful and beneficial effects of organic monosulfides, disulfides, and polysulfides in animals and humans.

Abstract：

:Many organic sulfides (mono-, di-, and polysulfides) are present in our environment. Simple derivatives are produced by some plants and animals, while complex sulfides are secondary metabolites of several genera of bacteria and fungi. Sulfides play an important role in the smell and taste of food, and many such compounds are used as food flavorings. Some sulfides are toxic, and there is evidence that such toxicity is caused by the ability of these substances to generate reactive oxygen species. Some sulfides, however, have been shown to protect against toxicants and carcinogens. These beneficial effects are believed to involve, at least in part, the ability of sulfides to inhibit the enzymatic activation of pro-toxicants and to increase tissue activities of enzymes that protect against electrophiles. Some sulfides also have potential as cancer chemotherapeutics. In this review, the toxic and beneficial effects of sulfides in animals are described, and the possible value of sulfides in cancer chemoprotection and cancer chemotherapy is discussed.

journal_name

Chem Res Toxicol

journal_title

Chemical research in toxicology

authors

Munday R

doi

10.1021/tx200373u

subject

Has Abstract

pub_date

2012-01-13 00:00:00

pages

47-60

issue

1

eissn

0893-228X

issn

1520-5010

journal_volume

25

pub_type

杂志文章,评审

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