当前位置： SCI文献检索 > CHEMICAL RESEARCH IN TOXICOLOGY期刊下所有文献 > Harmful and beneficial effects of organic monosulfides, disulfides, and polysulfides in animals and humans.

Harmful and beneficial effects of organic monosulfides, disulfides, and polysulfides in animals and humans.

Abstract：

:Many organic sulfides (mono-, di-, and polysulfides) are present in our environment. Simple derivatives are produced by some plants and animals, while complex sulfides are secondary metabolites of several genera of bacteria and fungi. Sulfides play an important role in the smell and taste of food, and many such compounds are used as food flavorings. Some sulfides are toxic, and there is evidence that such toxicity is caused by the ability of these substances to generate reactive oxygen species. Some sulfides, however, have been shown to protect against toxicants and carcinogens. These beneficial effects are believed to involve, at least in part, the ability of sulfides to inhibit the enzymatic activation of pro-toxicants and to increase tissue activities of enzymes that protect against electrophiles. Some sulfides also have potential as cancer chemotherapeutics. In this review, the toxic and beneficial effects of sulfides in animals are described, and the possible value of sulfides in cancer chemoprotection and cancer chemotherapy is discussed.

journal_name

Chem Res Toxicol

journal_title

Chemical research in toxicology

authors

Munday R

doi

10.1021/tx200373u

subject

Has Abstract

pub_date

2012-01-13 00:00:00

pages

47-60

issue

1

eissn

0893-228X

issn

1520-5010

journal_volume

25

pub_type

杂志文章,评审

相关文献

CHEMICAL RESEARCH IN TOXICOLOGY文献大全
  • Photoaddition of fluphenazine to nucleophiles in peptides and proteins. Possible cause of immune side effects.

    abstract：:By the action of UVA light, fluphenazine reacted with nucleophiles through a mechanism involving defluorination of its trifluoromethyl group, giving rise to carboxylic acid derivatives that were easily detected by electrospray mass spectrometry. This photoreaction took place with alcohols, sulphydryls, and amines. Whe...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700123u

    authors： Caffieri S,Miolo G,Seraglia R,Dalzoppo D,Toma FM,van Henegouwen GM

    更新日期：2007-10-01 00:00:00

  • Gas Chromatography-Tandem Mass Spectrometry Verification of Sulfur Mustard Exposure in Humans through the Conversion of Protein Adducts to Free Sulfur Mustard.

    abstract：:Exposures to sulfur mustard (HD; bis(2-chloroethyll) sulfide) are well-known to result in the formation of adducts with free aspartate and glutamate residues of plasma proteins (Lawrence, R. J., Smith, J. R., and Capacio, B. R. 2008 32, (1), 31-36). A modified version of the analytical method reported previously for t...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.0c00134

    authors： Young SA,Capacio BR

    更新日期：2020-07-20 00:00:00

  • Synthesis, characterization, and quantitation of a 4-aminobiphenyl-DNA adduct standard.

    abstract：:32P-Postlabeling is a powerful technique for the detection of DNA adducts; however, quantitation of DNA adducts by this method can result in errors due to differences in hydrolysis and labeling efficiencies between adducted and normal nucleotides. We have synthesized a DNA sample modified with 4-aminobiphenyl to serve...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx980172y

    authors： Beland FA,Doerge DR,Churchwell MI,Poirier MC,Schoket B,Marques MM

    更新日期：1999-01-01 00:00:00

  • Synthesis and structural characterization of the N2G-mitomycin C-N2G interstrand cross-link in a model synthetic 23 base pair oligonucleotide DNA duplex.

    abstract：:Mitomycin C (MMC) is a genotoxic cancer chemotherapeutic agent that reacts principally at the N2 position of guanine to form one of two predominant monoadducts, or a G-G interstrand cross-link at CpG sites, or a G-G intrastrand cross-link at GpG sites. Previous studies of MMC adduction have principally used very short...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx960070c

    authors： Warren AJ,Hamilton JW

    更新日期：1996-10-01 00:00:00

  • Metabonomic evaluation of Schaedler altered microflora rats.

    abstract：:Previously, we identified two distinct metabonomic phenotypes in Sprague-Dawley rats sourced from two different rooms (colonies) in the Charles River, Raleigh facility [Robosky, L. C., Wells, D. F., Egnash, L. A., Manning, M. L., Reily, M. D., and Robertson, D. G. (2005) Metabonomic identification of two distinct phen...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700184u

    authors： Rohde CM,Wells DF,Robosky LC,Manning ML,Clifford CB,Reily MD,Robertson DG

    更新日期：2007-10-01 00:00:00

  • Impact of Physicochemical Properties on Dose and Hepatotoxicity of Oral Drugs.

    abstract：:A database containing maximum daily doses of 1841 marketed oral drugs was used to examine the influence of physicochemical properties on dose and hepatotoxicity (drug induced liver injury, DILI). Drugs in the highest ∼20% dose range had significantly reduced mean lipophilicity and molecular weight, increased fractiona...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.8b00044

    authors： Leeson PD

    更新日期：2018-06-18 00:00:00

  • A kinetic model of the cell culture cytotoxicity of metabolically activated agents: N-methyl-N-(acetoxymethyl)nitrosamine, methylnitrosourethane, and (methylazoxy)methanol acetate.

    abstract：:The activity of three metabolically activated methylating agents, N-methyl-N-(acetoxymethyl)nitrosamine (DMN-OAc), methylnitrosourethane (MNUT), and (methylazoxy)methanol acetate (MAM-Ac), were determined in cell culture by using a P388 cell growth rate inhibition assay. Experiments were conducted with normal P388 cel...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00011a004

    authors： Weinkam RJ,Plakunov I

    更新日期：1989-09-01 00:00:00

  • Highly galloylated tannin fractions from witch hazel (Hamamelis virginiana) bark: electron transfer capacity, in vitro antioxidant activity, and effects on skin-related cells.

    abstract：:Witch hazel ( Hammamelis virginiana) bark is a rich source of both condensed and hydrolizable oligomeric tannins. From a polyphenolic extract soluble in both ethyl acetate and water, we have generated fractions rich in pyrogallol-containing polyphenols (proanthocyanidins, gallotannins, and gallates). The mixtures were...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700425n

    authors： Touriño S,Lizárraga D,Carreras A,Lorenzo S,Ugartondo V,Mitjans M,Vinardell MP,Juliá L,Cascante M,Torres JL

    更新日期：2008-03-01 00:00:00

  • Role of thiocyanate ion in detoxification of the anticancer agent chlorambucil.

    abstract：:N,N-Bis(2-chloroethyl)-p-aminophenylbutyric acid (chlorambucil, 1) is an orally administrated drug widely used in the chemotherapy of chronic lymphocytic leukemia. We have recently described a new metabolic path for the decomposition of 1 in human gastric juice based on its reactions with saliva-derived thiocyanate io...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx980122t

    authors： Hovinen J,Pettersson-Fernholm T,Lahti M,Vilpo J

    更新日期：1998-11-01 00:00:00

  • Synthesis, absolute configuration, and bacterial mutagenicity of the 8 stereoisomeric vicinal diol epoxides at the terminal benzo ring of carcinogenic dibenz[a,h]anthracene.

    abstract：:The synthesis of the 8 possible stereoisomeric diol epoxides (DEs) at the terminal benzo ring of carcinogenic dibenz[a,h]anthracene (DBA) is reported. trans-3,4-Dihydroxy-3,4-dihydro-DBA (1) afforded the 4 bay region DEs: the enantiomeric pairs of the anti diastereomers (+)-3/(-)-3 and of the syn diastereomers (-)-4/(...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx200398b

    authors： Frank H,Funk M,Oesch F,Platt KL

    更新日期：2011-12-19 00:00:00

  • Large-scale synthesis of the catechol metabolites of diethylstilbestrol and hexestrol.

    abstract：:Diethylstilbestrol (DES) and hexestrol (HES) are carcinogenic synthetic estrogens. The major metabolites of these compounds are their catechol derivatives, 3'-OH-DES and 3'-OH-HES. Oxidation of these metabolites leads to the electrophilic quinones, which are presumably involved in the tumor-initiating process. A synth...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx970140v

    authors： Jan ST,Rogan EG,Cavalieri EL

    更新日期：1998-05-01 00:00:00

  • Studies on the adduct heterogeneity of benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy.

    abstract：:The binding conformations of single anti- and syn-BPDE-N2-dG adducts in oligonucleotides of varying base composition have been studied by induced circular dichroism (ICD) and light absorption spectroscopy. The sign of the ICD in single-stranded oligonucleotide adducts correlates with the absolute configuration of the ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx9702244

    authors： Pradhan P,Jernström B,Seidel A,Nordén B,Gräslund A

    更新日期：1999-05-01 00:00:00

  • Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction.

    abstract：:Cr(VI) genotoxicity is caused by products of its reductive metabolism inside the cells. Reactive oxygen species (ROS) and Cr(V,IV) intermediates are potential sources of oxidative damage by Cr(VI). Here, we investigated seven fluorescent probes for the detection of ROS and non-ROS oxidants in Cr(VI) reactions with its...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx500028x

    authors： DeLoughery Z,Luczak MW,Zhitkovich A

    更新日期：2014-05-19 00:00:00

  • Synthesis and sequence-specific DNA binding of a topoisomerase inhibitory analog of Hoechst 33258 designed for altered base and sequence recognition.

    abstract：:The preparation and DNA binding characteristics of a structural analog of Hoechst 33258 bearing two pyridinic nitrogen atoms are described. The 1H NMR signals of the complex formed between the new ligand 1 and decadeoxyribonucleotide d(CATGGCCATG)2 were assigned by employing one- and two-dimensional NMR techniques. In...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00029a003

    authors： Singh MP,Joseph T,Kumar S,Bathini Y,Lown JW

    更新日期：1992-09-01 00:00:00

  • Verification of the structural alerts for Michael acceptors.

    abstract：:A diverse series of polarized alpha,beta-unsaturated and related compounds were evaluated for reactivity with a spectrophotometric assay using the sulfhydryl group in the form of the cysteine residue of the tripeptide GSH as a model nucleophile. The reactive end point (RC 50) calculations were compared to previously d...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700212u

    authors： Schultz TW,Yarbrough JW,Hunter RS,Aptula AO

    更新日期：2007-09-01 00:00:00

  • Development of a thyroperoxidase inhibition assay for high-throughput screening.

    abstract：:High-throughput screening (HTPS) assays to detect inhibitors of thyroperoxidase (TPO), the enzymatic catalyst for thyroid hormone (TH) synthesis, are not currently available. Herein, we describe the development of a HTPS TPO inhibition assay. Rat thyroid microsomes and a fluorescent peroxidase substrate, Amplex UltraR...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx400310w

    authors： Paul KB,Hedge JM,Rotroff DM,Hornung MW,Crofton KM,Simmons SO

    更新日期：2014-03-17 00:00:00

  • Inhibition of hepatic microsomal cytochrome P-450 dependent monooxygenation activity by the antioxidant 3-tert-butyl-4-hydroxyanisole.

    abstract：:The efficacy of 3-tert-butyl-4-hydroxyanisole (BHA) as a chemopreventive agent against chemically induced cancer or toxicity may involve the direct modulation of cytochrome P-450 dependent monooxygenase function. This hypothesis was investigated by using purified rabbit cytochrome P-450IA2 and P-450IIB4 in a reconstit...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00021a004

    authors： Rodrigues AD,Fernandez D,Nosarzewski MA,Pierce WM Jr,Prough RA

    更新日期：1991-05-01 00:00:00

  • Cu(II)/H2O2-induced DNA damage is enhanced by packaging of DNA as a nucleosome.

    abstract：:Copper is a physiologically important, redox-active metal that may be involved in endogenous DNA damage and mutagenesis. To understand the factors that affect the location and quantity of copper-induced oxidative DNA damage in cells, we used the 5S rDNA nucleosome as a model to assess the effect of chromatin structure...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0002278

    authors： Liang Q,Dedon PC

    更新日期：2001-04-01 00:00:00

  • Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions.

    abstract：:Cancer-associated mutations often lead to perturbed cellular energy metabolism and accumulation of potentially harmful oncometabolites. One example is the chiral molecule 2-hydroxyglutarate (2HG); its two stereoisomers (d- and l-2HG) have been found at abnormally high concentrations in tumors featuring anomalous metab...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.7b00009

    authors： Chen F,Bian K,Tang Q,Fedeles BI,Singh V,Humulock ZT,Essigmann JM,Li D

    更新日期：2017-04-17 00:00:00

  • Metabolism of genistein by rat and human cytochrome P450s.

    abstract：:The metabolism of genistein (4',5,7-trihydroxyisoflavone), a phytoestrogen derived from soy products, was investigated using rat and human liver microsomes and recombinant human cytochrome P450 enzymes. Metabolism of genistein by microsomes obtained from rats treated with pyridine, phenobarbital, beta-naphthoflavone, ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx9802320

    authors： Roberts-Kirchhoff ES,Crowley JR,Hollenberg PF,Kim H

    更新日期：1999-07-01 00:00:00

  • Synthesis, Characterization, and Identification of New in Vitro Covalent DNA Adducts of Divinyl Sulfone, an Oxidative Metabolite of Sulfur Mustard.

    abstract：:Divinyl sulfone (DVS) is an important oxidative metabolic product of sulfur mustard (SM) in vitro and in vivo. Although DVS is not a classical blister agent, its high reactivity and toxicity induced by vinyl groups can also cause blisters like SM upon contact with the skin, eyes, and respiratory organs. The purpose of...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.7b00196

    authors： Lv S,Zhang Y,Xu B,Xu H,Zhao Y,Chen J,Gao Z,Wu J,Xie J

    更新日期：2017-10-16 00:00:00

  • Cyclooxygenase-2 expression is up-regulated by 2-aminobiphenyl in a ROS and MAPK-dependent signaling pathway in a bladder cancer cell line.

    abstract：:Overexposure to biphenyl amine compounds, which are found in smoke and azo-dyes, is linked to the occurrence of bladder cancer. However, the molecular mechanisms of biphenyl amine compound-induced bladder cancer are still unclear. Many studies have demonstrated that overexpression of cyclooxygenase-2 (COX-2) in neopla...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx2004689

    authors： Chen CC,Cheng YY,Chen SC,Tuan YF,Chen YJ,Chen CY,Chen LC

    更新日期：2012-03-19 00:00:00

  • Immunotoxicity induced by acute subtoxic doses of paraquat herbicide: implication of shifting cytokine gene expression toward T-helper (T(H))-17 phenotype.

    abstract：:Paraquat (PQ) is a free radical-inducing agent commonly used as an herbicide. This study assesses the acute immunotoxicity of PQ in BALB/c mice and examines its effect on cytokine gene expression profile. It was found that single subtoxic oral doses of 2, 4, and 20 mg/kg significantly inhibited the in vitro mitogen-in...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx300194t

    authors： Hassuneh MR,Albini MA,Talib WH

    更新日期：2012-10-15 00:00:00

  • Identification of a new mutagenic polychlorinated biphenyl derivative in the Waka River, Wakayama, Japan, showing activation of an aryl hydrocarbon receptor-dependent transcription.

    abstract：:Water samples from the Waka River, which runs through an area housing many chemical industry facilities in Wakayama, Japan, have been found to show significant mutagenicity, especially without a mammalian metabolic activation system (S9 mix) in the Salmonella typhimurium YG1024 strain. Mutagens in the river water were...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx010163g

    authors： Takamura-Enya T,Watanabe T,Tada A,Hirayama T,Nukaya H,Sugimura T,Wakabayashi K

    更新日期：2002-03-01 00:00:00

  • Metabolites and safety: What are the concerns, and how should we address them?

    abstract：:The issue of the safety of drug metabolites in humans is a complex one. In this commentary, a proposal is made regarding how to deal with drug metabolites observed in humans such that the safety of these molecules can be assured. The human radiolabeled ADME study, in which metabolites are identified and quantified in ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0602012

    authors： Smith DA,Obach RS

    更新日期：2006-12-01 00:00:00

  • Inhibition of skeletal sarcoplasmic reticulum Ca2+-ATPase activity by deferoxamine nitroxide free radical.

    abstract：:Deferoxamine is an inhibitor of iron-dependent free radical reactions. Despite the antioxidant roles, prolonged clinical use of the chelator is far from benign, and paradoxically, deferoxamine has been shown to promote lipid peroxidation. The possible toxicity of the drug's metabolites, such as deferoxamine nitroxide ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx980212y

    authors： Kiyose M,Lee CI,Okabe E

    更新日期：1999-02-01 00:00:00

  • Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry.

    abstract：:Quantitation of DNA adducts could provide critical information on the relationship between exposure to tobacco smoke and cancer risk in smokers. In this study, we developed a robust and sensitive liquid chromatography-tandem mass spectrometry method for the analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasin...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx300282k

    authors： Stepanov I,Muzic J,Le CT,Sebero E,Villalta P,Ma B,Jensen J,Hatsukami D,Hecht SS

    更新日期：2013-01-18 00:00:00

  • Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells.

    abstract：:Human exposure to abacavir, a primary alcohol antiretroviral, is associated with the development of immunological drug reactions in individuals carrying the HLA risk allele B*57:01. Interaction of abacavir with antigen presenting cells results in cell activation through an Hsp70-mediated Toll-like receptor pathway and...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx400041v

    authors： Bell CC,Santoyo Castelazo A,Yang EL,Maggs JL,Jenkins RE,Tugwood J,O'Neill PM,Naisbitt DJ,Park BK

    更新日期：2013-07-15 00:00:00

  • Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications.

    abstract：:The P450 type cytochromes are responsible for the metabolism of a wide variety of xenobiotics and endogenous compounds. Although P450-catalyzed reactions are generally thought to lead to detoxication of xenobiotics, the reactions can also produce reactive intermediates that can react with cellular macromolecules leadi...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章,评审

    doi：10.1021/tx7002504

    authors： Hollenberg PF,Kent UM,Bumpus NN

    更新日期：2008-01-01 00:00:00

  • Development of a Fragment-Based in Silico Profiler for Michael Addition Thiol Reactivity.

    abstract：:The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adverse effect. An important example of a well-defined MIE is the formatio...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.6b00099

    authors： Ebbrell DJ,Madden JC,Cronin MT,Schultz TW,Enoch SJ

    更新日期：2016-06-20 00:00:00