Abstract:
:While characterizing natural antiinflammatory substances in human placental blood, we discovered a factor that affected human neutrophils and their adherence. Rigorous chemical and stereochemical analyses revealed this factor to be the well-known alkaloid, colchicine. When samples from individual patients were analyzed, significant levels (49-763 microg/L) of colchicine could be found in placental blood of patients using nonprescription herbal dietary supplements during pregnancy. We confirmed the presence of colchicine in commercially available ginkgo biloba. Due to its potential harmful effects, it would appear that such supplements should be avoided by women who are pregnant or are trying to conceive.
journal_name
Chem Res Toxicoljournal_title
Chemical research in toxicologyauthors
Petty HR,Fernando M,Kindzelskii AL,Zarewych BN,Ksebati MB,Hryhorczuk LM,Mobashery Sdoi
10.1021/tx0155101subject
Has Abstractpub_date
2001-09-01 00:00:00pages
1254-8issue
9eissn
0893-228Xissn
1520-5010pii
tx0155101journal_volume
14pub_type
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journal_title:Chemical research in toxicology
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journal_title:Chemical research in toxicology
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更新日期:2004-02-01 00:00:00
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journal_title:Chemical research in toxicology
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journal_title:Chemical research in toxicology
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journal_title:Chemical research in toxicology
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journal_title:Chemical research in toxicology
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journal_title:Chemical research in toxicology
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更新日期:2018-03-19 00:00:00
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journal_title:Chemical research in toxicology
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journal_title:Chemical research in toxicology
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