Identification of colchicine in placental blood from patients using herbal medicines.

Abstract:

:While characterizing natural antiinflammatory substances in human placental blood, we discovered a factor that affected human neutrophils and their adherence. Rigorous chemical and stereochemical analyses revealed this factor to be the well-known alkaloid, colchicine. When samples from individual patients were analyzed, significant levels (49-763 microg/L) of colchicine could be found in placental blood of patients using nonprescription herbal dietary supplements during pregnancy. We confirmed the presence of colchicine in commercially available ginkgo biloba. Due to its potential harmful effects, it would appear that such supplements should be avoided by women who are pregnant or are trying to conceive.

journal_name

Chem Res Toxicol

authors

Petty HR,Fernando M,Kindzelskii AL,Zarewych BN,Ksebati MB,Hryhorczuk LM,Mobashery S

doi

10.1021/tx0155101

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

1254-8

issue

9

eissn

0893-228X

issn

1520-5010

pii

tx0155101

journal_volume

14

pub_type

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