Abstract：
:Concerns have been raised that diacetyl (DA) might be a respiratory sensitizer based on its LUMO energy similar to that of the respiratory allergen toluene-2,4-diisocyanate (TDI) and results of a local lymph node assay (LLNA) that reported an EC3 of 1.9%. To better understand the concerns, we performed a systematic literature review and experimental competition reactions between DA and TDI. The experimental evidence demonstrates that DA is at least 400-fold less reactive than TDI. The literature review finds evidence that the EC3 for DA is actually >11%. We conclude that DA is unlikely to have significant respiratory sensitization potential.
journal_name
Chem Res Toxicoljournal_title
Chemical research in toxicologyauthors
Dworak JJ,Roberts DW,Calter MA,Fields CA,Borak Jdoi
10.1021/tx400097vsubject
Has Abstractpub_date
2013-05-20 00:00:00pages
631-3issue
5eissn
0893-228Xissn
1520-5010journal_volume
26pub_type
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