Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease.

abstract：:Pyridoxamine (PM) is an effective inhibitor of the formation of the carcinogen acrylamide (AA) from its precursors in low-moisture model systems. Although AA is widely assumed to act by scavenging carbonyl compounds, no alternative pathways have to date been explored. In this work, we found AA to directly react with P...

journal_title：Chemical research in toxicology

authors： Arribas-Lorenzo G,Pintado-Sierra M,Morales FJ

更新日期：2011-03-21 00:00:00

abstract：:Cancer-associated mutations often lead to perturbed cellular energy metabolism and accumulation of potentially harmful oncometabolites. One example is the chiral molecule 2-hydroxyglutarate (2HG); its two stereoisomers (d- and l-2HG) have been found at abnormally high concentrations in tumors featuring anomalous metab...

journal_title：Chemical research in toxicology

authors： Chen F,Bian K,Tang Q,Fedeles BI,Singh V,Humulock ZT,Essigmann JM,Li D

更新日期：2017-04-17 00:00:00

abstract：:High-throughput screening (HTPS) assays to detect inhibitors of thyroperoxidase (TPO), the enzymatic catalyst for thyroid hormone (TH) synthesis, are not currently available. Herein, we describe the development of a HTPS TPO inhibition assay. Rat thyroid microsomes and a fluorescent peroxidase substrate, Amplex UltraR...

journal_title：Chemical research in toxicology

authors： Paul KB,Hedge JM,Rotroff DM,Hornung MW,Crofton KM,Simmons SO

更新日期：2014-03-17 00:00:00

abstract：:The present study describes a novel integrated approach for rapid analysis of reactive metabolites with a linear ion trap mass spectrometer (LTQ). In this approach, an isotope pattern-dependent scanning method was applied to the data acquisition of glutathione (GSH)-trapped reactive metabolites. Recorded full-scan MS ...

journal_title：Chemical research in toxicology

authors： Ma L,Wen B,Ruan Q,Zhu M

更新日期：2008-07-01 00:00:00

abstract：:The measurement of metabolites constitutes a useful tool for detection of exposure and in pharmacokinetic studies. Epoxidation with subsequent glutathione conjugation and mercapturic acid formation is an important deactivation pathway for naphthalene, a toxin which presumably causes lung disease. The mercapturic acid ...

journal_title：Chemical research in toxicology

authors： Marco MP,Nasiri M,Kurth MJ,Hammock BD

更新日期：1993-05-01 00:00:00

abstract：:Notopterygium forbesii Boiss (NF) has been used as a traditional Chinese medicine for the treatment of common cold and rheumatism. However, there has been limited research on the biological properties of NF, and the mechanisms of action remain unknown. Here, we aimed to study the mechanism of NF-induced heme oxygenase...

journal_title：Chemical research in toxicology

authors： Tang SY,Wang H,Zhang W,Halliwell B

更新日期：2008-12-01 00:00:00

abstract：:Understanding the molecular basis of inorganic chemical toxicity has lagged behind the proliferation of detailed mechanisms that explain the biochemical toxicology of many organic xenobiotics. In this perspective, general barriers to explicating the bioinorganic chemistry of toxic metals are considered, followed by a ...

journal_title：Chemical research in toxicology

authors： Petering DH

更新日期：2017-01-17 00:00:00

abstract：:Radionuclides represent a serious health risk to humans in the case of incorporation. To elucidate the potential of time-resolved laser-induced fluorescence spectroscopy (TRLFS) to determine the dominant radionuclide species in natural biofluids, we investigated the in vitro speciation of curium(III) in human urine sa...

journal_title：Chemical research in toxicology

authors： Heller A,Barkleit A,Bernhard G

更新日期：2011-02-18 00:00:00

abstract：:In aqueous media at neutral pH, the binding of two cyanide molecules per cobinamide can be described by two formation constants, Kf1 = 1.1 (±0.6) × 105 M-1 and Kf2 = 8.5 (±0.1) × 104 M-1, or an overall cyanide binding constant of ∼1 × 1010 M-2. In comparison, the cyanide binding constants for cobalamin and a fully oxi...

journal_title：Chemical research in toxicology

authors： Yuan Q,Pearce LL,Peterson J

更新日期：2017-12-18 00:00:00

abstract：:Trichloroethylene (TCE), a widely used industrial solvent, is a common environmental contaminant. We previously reported that TCE-induced changes in DNA methylation and miRNA expression contributed to the development of a liver tumor in mice. In this study, we investigated the role of long intergenic noncoding RNA (Li...

journal_title：Chemical research in toxicology

authors： Ren F,Wang J,Aniagu S,Li J,Jiang Y,Chen T

更新日期：2020-06-15 00:00:00

abstract：:We have previously reported that mono- and dichlorinated biphenyls (PCBs) can be metabolized to dihydroxy compounds and further oxidized to reactive metabolites which form adducts with nitrogen and sulfur nucleophiles including DNA [Amaro et al. (1966) Chem. Res. Toxicol. 9, 623-629; Oakley et al. (1996) Carcinogenesi...

journal_title：Chemical research in toxicology

authors： Oakley GG,Devanaboyina U,Robertson LW,Gupta RC

更新日期：1996-12-01 00:00:00

abstract：:Electrophilic DNA adducts produced following oxidative stress can form DNA-protein cross-links (DPCs), dramatically altering genomic maintenance pathways. Complete characterization of DPCs has been hindered, in part, because of a lack of comprehensive techniques for their analysis. We have, therefore, established a pr...

journal_title：Chemical research in toxicology

authors： Shuck SC,Rose KL,Marnett LJ

更新日期：2014-01-21 00:00:00

abstract：:Drug hypersensitivity reactions adversely affect treatment outcome, increase the length of patients' hospitalization, and limit the prescription options available to physicians. In addition, late stage drug attrition and the withdrawal of licensed drugs cost the pharmaceutical industry billions of dollars. This signif...

journal_title：Chemical research in toxicology

authors： Hammond S,Thomson PJ,Ogese MO,Naisbitt DJ

更新日期：2020-01-21 00:00:00

abstract：:The formation of 8-oxo-7,8-dihydroguanine (G(O), 8-hydroxyguanine) in DNA and in the nucleotide pool results in G:C→T:A and A:T→C:G substitution mutations, respectively, since G(O) can pair with both C and A. In this study, the role of DNA polymerase κ in the mutagenicity of G(O) was investigated, using a supF shuttle...

journal_title：Chemical research in toxicology

authors： Kamiya H,Kurokawa M

更新日期：2012-08-20 00:00:00

abstract：:In May 1981, a massive food-borne intoxication occurred in Spain. The so-called toxic oil syndrome (TOS) was associated with the consumption of aniline-denatured and refined rapeseed oil that was illegally sold as edible olive oil. Fatty acid anilides and fatty acid derivatives of 3-(phenylamino)propane-1,2-diol were ...

journal_title：Chemical research in toxicology

authors： Ladona MG,Bujons J,Messeguer A,Ampurdanés C,Morató A,Corbella J

更新日期：1999-12-01 00:00:00

abstract：:The perfluorinated carboxylic acid, perfluoro-n-decanoic acid (PFDA), is a known peroxisome proliferator which displays toxicity in rodents. Using a paired-tracer first-pass extraction technique, the effect of PFDA on hepatic glucose transport was determined in the isolated perfused rat liver. In brief, livers isolate...

journal_title：Chemical research in toxicology

authors： Goecke-Flora CM,Wyman JF,Jarnot BM,Reo NV

更新日期：1995-01-01 00:00:00

abstract：:Cells respond to stress by controlling gene expression at several levels, with little known about the role of translation. Here, we demonstrate a coordinated translational stress response system involving stress-specific reprogramming of tRNA wobble modifications that leads to selective translation of codon-biased mRN...

journal_title：Chemical research in toxicology

authors： Chan CT,Deng W,Li F,DeMott MS,Babu IR,Begley TJ,Dedon PC

更新日期：2015-05-18 00:00:00

abstract：:Caffeine on alkaline hydrolysis produces caffeidine [1-methyl-4-(methylamino)-5-(N-methylcarbamoyl)imidazole] and caffeidine acid [N-[4-(5-carboxy-1-methylimidazolyl)]-N,N'-dimethylurea]. We now report the synthesis and chemical characterization of mononitrosocaffeidine [1-methyl-4-(N-methyl-N-nitrosoamino)-5-(N-methy...

journal_title：Chemical research in toxicology

authors： Kumar R,Wacker CD,Mende P,Spiegelhalder B,Preussmann R,Siddiqi M

更新日期：1993-01-01 00:00:00

abstract：:Cyadox is a novel derivative of quinoxaline-1,4-dioxides (QdNOs) with the potential to be developed as a feed additive. However, the pharmacological and toxicological bioactive molecules of cyadox and the molecular mechanism of its pharmacological and toxic actions remain unclear. In the present study, cyadox and its ...

journal_title：Chemical research in toxicology

authors： Liu Q,Lei Z,Zhou K,Yu H,Liu S,Sun Q,Wang X,Dai M,Yuan Z

更新日期：2018-11-19 00:00:00

abstract：:By the action of UVA light, fluphenazine reacted with nucleophiles through a mechanism involving defluorination of its trifluoromethyl group, giving rise to carboxylic acid derivatives that were easily detected by electrospray mass spectrometry. This photoreaction took place with alcohols, sulphydryls, and amines. Whe...

journal_title：Chemical research in toxicology

authors： Caffieri S,Miolo G,Seraglia R,Dalzoppo D,Toma FM,van Henegouwen GM

更新日期：2007-10-01 00:00:00

abstract：:Cyclic imides are known for their antitumor activity, especially the naphthalimide derivatives, such as Mitonafide and Amonafide. Recently, we have demonstrated the cytotoxic effect of a series of naphthalimide derivatives against B16F10 melanoma cells. On the basis of this fact, we have developed a study starting fro...

journal_title：Chemical research in toxicology

authors： Machado KE,de Oliveira KN,Andreossi HM,Bubniak Ldos S,de Moraes AC,Gaspar PC,Andrade Eda S,Nunes RJ,Santos-Silva MC

更新日期：2013-12-16 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are formed during incomplete combustion of organic material and are ubiquitous environmental contaminants. High levels of PAHs are commonly found in soils at industrial sites, thereby constituting a risk for humans and the environment. However, this risk is often difficult to es...

journal_title：Chemical research in toxicology

authors： Niziolek-Kierecka M,Dreij K,Lundstedt S,Stenius U

更新日期：2012-04-16 00:00:00

abstract：:Retinyl palmitate (RP) is frequently used as an ingredient in cosmetics and other retail products. We previously reported that, under UVA light irradiation, RP is facilely decomposed into multiple products, including anhydroretinol (AR) and 5,6-epoxyretinyl palmitate (5,6-epoxy-RP). We also determined that combined tr...

journal_title：Chemical research in toxicology

authors： Mei N,Xia Q,Chen L,Moore MM,Chen T,Fu PP

更新日期：2006-11-01 00:00:00

abstract：:Cytochrome P450 enzymes (CYPs) metabolize alkyl- and arylamines, generating several different products. For the primary and secondary amines, some of these reactions result in hydroxylated amines, which may be toxic. Thus, when designing new drugs containing amine groups, it is important to be able to predict if a giv...

journal_title：Chemical research in toxicology

authors： Seger ST,Rydberg P,Olsen L

更新日期：2015-04-20 00:00:00

abstract：:Sulfhydration by a hydrogen sulfide anion and electrophile thiolation by reactive sulfur species (RSS) such as persulfides/polysulfides (e.g., R-S-SH/R-S-Sn-H(R)) are unique reactions in electrophilic signaling. Using 1,2-dihydroxynaphthalene-4-thioacetate (1,2-NQH2-SAc) as a precursor to 1,2-dihydroxynaphthalene-4-th...

journal_title：Chemical research in toxicology

authors： Shinkai Y,Abiko Y,Ida T,Miura T,Kakehashi H,Ishii I,Nishida M,Sawa T,Akaike T,Kumagai Y

更新日期：2015-05-18 00:00:00

abstract：:To reveal the roles of Y family DNA polymerases in the mutagenesis induced by oxidatively damaged DNA precursors, 2-hydroxy-dATP (2-OH-dATP) and 8-hydroxy-dGTP (8-OH-dGTP) were introduced into Escherichia coli strains deficient in the Y family polymerases, DNA polymerase IV (pol IV, encoded by the dinB gene) and DNA p...

journal_title：Chemical research in toxicology

authors： Satou K,Yamada M,Nohmi T,Harashima H,Kamiya H

更新日期：2005-08-01 00:00:00

abstract：:Diethylstilbestrol (DES) and hexestrol (HES) are carcinogenic synthetic estrogens. The major metabolites of these compounds are their catechol derivatives, 3'-OH-DES and 3'-OH-HES. Oxidation of these metabolites leads to the electrophilic quinones, which are presumably involved in the tumor-initiating process. A synth...

journal_title：Chemical research in toxicology

authors： Jan ST,Rogan EG,Cavalieri EL

更新日期：1998-05-01 00:00:00

abstract：:DNA nucleobases are the prime targets for chemical modifications by endogenous and exogenous electrophiles. Alkylation of the N7 position of guanine and adenine in DNA triggers base-catalyzed imidazole ring opening and the formation of N5-substituted formamidopyrimidine (N5-R-FAPy) lesions. Me-FAPy-dG adducts induced ...

journal_title：Chemical research in toxicology

authors： Pujari SS,Tretyakova N

更新日期：2017-01-17 00:00:00

abstract：:Human exposure to engineered nanomaterials (ENMs) is inevitable due to the plethora of applications for which they are being manufactured and integrated within. ENMs demonstrate plentiful advantages in terms of industrial approaches as well as from a consumer perspective. However, despite such positives, doubts remain...

journal_title：Chemical research in toxicology

authors： Cronin JG,Jones N,Thornton CA,Jenkins GJS,Doak SH,Clift MJD

更新日期：2020-05-18 00:00:00

abstract：:With CO2 present in excess, ONOO- reacts to form an adduct in solution and in the solid state, most likely ONOOCO2-. In solution, the adduct appears within 2 ms and absorbs at 300 with an extinction coefficient, which is either 50% or 100% (preferred) of that of ONOO-, 1.70 × 103 M-1 cm-1, and at 685 nm with an extinc...

journal_title：Chemical research in toxicology

authors： Serrano-Luginbuehl S,Kissner R,Koppenol WH

更新日期：2018-08-20 00:00:00