Characterization of benzo[a]pyrene anti-diol epoxide adducts to human histones.

abstract：:We have reported [Correia et al. (1987) Arch. Biochem. Biophys. 258, 436-443] that administration of 3,5-dicarbethoxy-4-ethyl-2,6-dimethyl-1,4-dihydropyridine (DDEP) to untreated, phenobarbital (PB) pretreated, or dexamethasone (DEX) pretreated rats results in relatively selective inactivation of cytochrome P-450 (P-4...

journal_title：Chemical research in toxicology

authors： Sugiyama K,Yao K,Rettie AE,Correia MA

更新日期：1989-11-01 00:00:00

abstract：:The diarrhetic shellfish toxin composition in the digestive glands of mussels collected in June 2001 from the Northern Adriatic sea was investigated by high-performance liquid chromatography coupled with electrospray ion trap mass spectrometry. Along with known yessotoxins (1, 3-6), identified by comparison of their r...

journal_title：Chemical research in toxicology

authors： Ciminiello P,Dell'Aversano C,Fattorusso E,Forino M,Magno S,Poletti R

更新日期：2002-07-01 00:00:00

abstract：:The binding of arsenite, As(III), and arsenate, As(V), by molecules in the intracellular compartment of rabbit erythrocytes has been studied by 1H- and 31P-NMR spectroscopy, uptake of 73As, and ultrafiltration experiments. For intact erythrocytes to which 0.1-0.4 mM arsenite was added, direct evidence was obtained for...

journal_title：Chemical research in toxicology

authors： Delnomdedieu M,Basti MM,Styblo M,Otvos JD,Thomas DJ

更新日期：1994-09-01 00:00:00

abstract：:Acyl glucuronides (AGs) are reactive metabolites of carboxylic acid-containing drugs, which are associated with idiosyncratic toxicity (IDT) such as anaphylaxis, drug-induced liver injury, and so on. In this study, we developed a new in vitro approach for the quantitative assessment of the reactivity of AGs and their ...

journal_title：Chemical research in toxicology

authors： Harada H,Toyoda Y,Abe Y,Endo T,Takeda H

更新日期：2019-10-21 00:00:00

abstract：:Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-glucuronosyltransferases (UGTs). The aim of the current study was to test the ...

journal_title：Chemical research in toxicology

authors： Greer AK,Madadi NR,Bratton SM,Eddy SD,Mazerska Z,Hendrickson HP,Crooks PA,Radominska-Pandya A

更新日期：2014-04-21 00:00:00

abstract：:A new experimental model was designed to study the fate of globin adducts with styrene 7,8-oxide (SO), a metabolic intermediate of styrene and a model electrophilic compound. Rat erythrocytes were incubated with SO at 7 or 22 °C. Levels of specific amino acid adducts in globin were determined by LC/MS analysis of the ...

journal_title：Chemical research in toxicology

authors： Mráz J,Hanzlíková I,Moulisová A,Dušková Š,Hejl K,Bednářová A,Dabrowská L,Linhart I

更新日期：2016-04-18 00:00:00

abstract：:Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various pathophysiological liver diseases and induced by structurally variable hepatotoxic chemicals. A putative common feature for all of these conditions is altered cellular redox status. Nuclear factor erythroid 2-like 2 (Nrf2) is a transcription factor that is p...

journal_title：Chemical research in toxicology

authors： Lämsä V,Levonen AL,Leinonen H,Ylä-Herttuala S,Yamamoto M,Hakkola J

更新日期：2010-05-17 00:00:00

abstract：:The leaves of the Mitragynine speciosia tree (also known as Kratom) have long been chewed, smoked, or brewed into a tea by people in Southeastern Asian countries, such as Malaysia and Thailand. Just this past year, the plant Kratom gained popularity in the United States as a "legal opioid" and scheduling it as a drug ...

journal_title：Chemical research in toxicology

authors： Smith LC,Lin L,Hwang CS,Zhou B,Kubitz DM,Wang H,Janda KD

更新日期：2019-01-22 00:00:00

abstract：:Arylamines (AAs) and heterocyclic aromatic amines (HAAs) are structurally related carcinogens formed during the combustion of tobacco or cooking of meat. They undergo cytochrome P450 mediated N-hydroxylation to form metabolites which bind to DNA and lead to mutations. The N-hydroxylated metabolites of many AAs also ca...

journal_title：Chemical research in toxicology

authors： Pathak KV,Chiu TL,Amin EA,Turesky RJ

更新日期：2016-03-21 00:00:00

abstract：:(R)-Thalidomide was oxidized to 5-hydroxythalidomide and 5'-hydroxythalidomide by NADPH-fortified liver microsomes from humans and monkeys. (R)-Thalidomide was hydroxylated more efficiently than (S)-thalidomide. Recombinant human P450s 3A4, 3A5, and 3A7 and monkey P450s 3A8 and 3A5 (coexpressed with NADPH-P450 reducta...

journal_title：Chemical research in toxicology

authors： Chowdhury G,Murayama N,Okada Y,Uno Y,Shimizu M,Shibata N,Guengerich FP,Yamazaki H

更新日期：2010-06-21 00:00:00

abstract：:Flavonols are potent naturally occurring antioxidants. Chemical oxidation reactions in combination with modern spectroscopic techniques have been employed to identify oxidized flavonoid products. Although many oxidized derivatives have been generated from commercially available starting materials, few studies have dev...

journal_title：Chemical research in toxicology

authors： Krishnamachari V,Levine LH,Zhou C,Paré PW

更新日期：2004-06-01 00:00:00

abstract：:The preparation and DNA binding characteristics of a structural analog of Hoechst 33258 bearing two pyridinic nitrogen atoms are described. The 1H NMR signals of the complex formed between the new ligand 1 and decadeoxyribonucleotide d(CATGGCCATG)2 were assigned by employing one- and two-dimensional NMR techniques. In...

journal_title：Chemical research in toxicology

authors： Singh MP,Joseph T,Kumar S,Bathini Y,Lown JW

更新日期：1992-09-01 00:00:00

abstract：:Carbon-13 NMR spectroscopy was used to study the effects of the peroxisome proliferator perfluoro-n-decanoic acid (PFDA) on hepatic carbohydrate metabolism in male Fischer-344 rats. The data indicate that PFDA-treated rats display an inhibition in hepatic [1-13C]glucose and [3-13C]alanine utilization on day 5 posttrea...

journal_title：Chemical research in toxicology

authors： Goecke CM,Jarnot BM,Reo NV

更新日期：1994-01-01 00:00:00

abstract：:Prodrugs of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) are promising anticancer agents. The 90CE moiety is a readily latentiated, short-lived (t1/2 ∼ 30 s) chloroethylating agent that can generate high yields of oxophilic electrophiles responsible for the chloroethylation of the O-6 position of guanine ...

journal_title：Chemical research in toxicology

authors： Penketh PG,Patridge E,Shyam K,Baumann RP,Zhu R,Ishiguro K,Sartorelli AC

更新日期：2014-08-18 00:00:00

abstract：:Sulfhydration by a hydrogen sulfide anion and electrophile thiolation by reactive sulfur species (RSS) such as persulfides/polysulfides (e.g., R-S-SH/R-S-Sn-H(R)) are unique reactions in electrophilic signaling. Using 1,2-dihydroxynaphthalene-4-thioacetate (1,2-NQH2-SAc) as a precursor to 1,2-dihydroxynaphthalene-4-th...

journal_title：Chemical research in toxicology

authors： Shinkai Y,Abiko Y,Ida T,Miura T,Kakehashi H,Ishii I,Nishida M,Sawa T,Akaike T,Kumagai Y

更新日期：2015-05-18 00:00:00

abstract：:Human exposure to abacavir, a primary alcohol antiretroviral, is associated with the development of immunological drug reactions in individuals carrying the HLA risk allele B*57:01. Interaction of abacavir with antigen presenting cells results in cell activation through an Hsp70-mediated Toll-like receptor pathway and...

journal_title：Chemical research in toxicology

authors： Bell CC,Santoyo Castelazo A,Yang EL,Maggs JL,Jenkins RE,Tugwood J,O'Neill PM,Naisbitt DJ,Park BK

更新日期：2013-07-15 00:00:00

abstract：:N(6)-(2-Hydroxy-3-buten-1-yl)-2'-deoxyadenosine (N(6)-HB-dA I) and N(6),N(6)-(2,3-dihydroxybutan-1,4-diyl)-2'-deoxyadenosine (N(6),N(6)-DHB-dA) are exocyclic DNA adducts formed upon alkylation of the N(6) position of adenine in DNA by epoxide metabolites of 1,3-butadiene (BD), a common industrial and environmental che...

journal_title：Chemical research in toxicology

authors： Kotapati S,Wickramaratne S,Esades A,Boldry EJ,Quirk Dorr D,Pence MG,Guengerich FP,Tretyakova NY

更新日期：2015-07-20 00:00:00

abstract：:Hydrophobic and volatile chemicals have proven to be difficult to dose in cell assays. Cosolvents are often needed to dissolve these chemicals in cell culture medium. Moreover, the free concentration of these chemicals in culture medium may diminish over time due to metabolism, evaporation, and nonspecific binding to ...

journal_title：Chemical research in toxicology

authors： Kramer NI,Busser FJ,Oosterwijk MT,Schirmer K,Escher BI,Hermens JL

更新日期：2010-11-15 00:00:00

abstract：:It is vital that methylated trivalent arsenicals [MA(III) and DMA(III)] are described and characterized unequivocally due to their high toxicity. Two different ways of generating the methylated trivalent arsenicals have been practiced-reduction of the methylated pentavalent arsenical either by the sodium-metabisulfite...

journal_title：Chemical research in toxicology

authors： Hansen HR,Raab A,Jaspars M,Milne BF,Feldmann J

更新日期：2004-08-01 00:00:00

abstract：:In humans and mice, in utero exposure to inorganic arsenic (iAs) is associated with adverse health outcomes later in life. The contribution of preconception exposure to the adverse outcomes in offspring has never been studied. Here combined in utero and postnatal exposures produce insulin resistance in two collaborati...

journal_title：Chemical research in toxicology

authors： Fry RC,Addo KA,Bell TA,Douillet C,Martin E,Stýblo M,Pardo-Manuel de Villena F

更新日期：2019-08-19 00:00:00

abstract：:Hemoglobin adducts have been used to assess exposure to carcinogenic compounds in tobacco smoke. However, because of background levels in nonsmokers, most adducts that have been studied are not useful for monitoring low-level exposure. Bergmark [(1997) Chem. Res. Toxicol. 10, 78-84] showed that the level of adducts of...

journal_title：Chemical research in toxicology

authors： Pérez HL,Segerbäck D,Osterman-Golkar S

更新日期：1999-10-01 00:00:00

abstract：:The relation between organophosphorus-induced delayed neuropathy (OPIDN) and brain neuropathy target esterase (NTE) inhibition is further examined in hens by structure-activity studies leading to the most potent in vitro NTE inhibitors known, which are then examined for their neuropathic effects in vivo in hens. The p...

journal_title：Chemical research in toxicology

authors： Wu SY,Casida JE

更新日期：1995-12-01 00:00:00

abstract：:Formyl chloride has been indirectly implicated as an intermediate in the oxidation of CH(2)Cl(2) and proposed to be a product of the oxidation of some other compounds. Formyl chloride was synthesized and added to aqueous solutions, with CO formed as a product. The presence of glutathione (GSH) did not reduce the yield...

journal_title：Chemical research in toxicology

authors： Watanabe K,Guengerich FP

更新日期：2006-08-01 00:00:00

abstract：:The guidelines embodied in this document were revised by the editors of the Publication Division of the American Chemical Society in January 1994 and endorsed by the Society Committee on Publications. ...

journal_title：Chemical research in toxicology

authors：

更新日期：1994-07-01 00:00:00

abstract：:Little is known about the formation and disposition of benzene oxide (BO), the initial metabolite arising from oxidation of benzene by cytochrome P450. In this study, reactions of BO with hemoglobin (Hb) and albumin (Alb) were investigated in blood from B6C3F1 mice, F344 rats, and humans in vitro. The estimated half-l...

journal_title：Chemical research in toxicology

authors： Lindstrom AB,Yeowell-O'Connell K,Waidyanatha S,McDonald TA,Golding BT,Rappaport SM

更新日期：1998-04-01 00:00:00

abstract：:Benzo[a]pyrene, a potent human carcinogen, is metabolized in vivo to a diol epoxide that reacts with the N2-position of guanine to produce N2-BP-dG adducts. These adducts are mutagenic causing G to T transversions. These adducts block replicative polymerases but can be bypassed by the Y-family translesion synthesis po...

journal_title：Chemical research in toxicology

authors： Gowda ASP,Krzeminski J,Amin S,Suo Z,Spratt TE

更新日期：2017-05-15 00:00:00

abstract：:Finger 3 of transcription factor IIIA of Xenopus laevis was synthesized and constituted with Zn(2+) or Cd(2+). The C-block element of the internal control region of the promoter of the 5S rRNA gene binds to the Zn-F3 and Cd-F3 with dissociation constants of 2.6 x 10(-5) and 1.5 x 10(-4) M, respectively. According to N...

journal_title：Chemical research in toxicology

authors： Krepkiy D,Försterling FH,Petering DH

更新日期：2004-07-01 00:00:00

abstract：:Aflatoxin Q1 8,9-oxide was synthesized and found to yield lower levels of N7-guanyl adducts than obtained from aflatoxin B1 8,9-oxide when mixed with calf thymus DNA or Salmonella typhimurium TA 98 cells. However, when S. typhimurium TA 98 was treated with the (analogous) epoxides of aflatoxin B1, aflatoxin G1, aflato...

journal_title：Chemical research in toxicology

authors： Raney KD,Shimada T,Kim DH,Groopman JD,Harris TM,Guengerich FP

更新日期：1992-03-01 00:00:00

abstract：:A liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) method for the measurement of aflatoxin biomarkers in urine has been developed and validated. The two major aflatoxin-DNA adducts formed in rat tissues, aflatoxin N(7)-guanine and its imidazole ring opened derivative, 8,9-dihydro-8-(2,6-diami...

journal_title：Chemical research in toxicology

authors： Walton M,Egner P,Scholl PF,Walker J,Kensler TW,Groopman JD

更新日期：2001-07-01 00:00:00

abstract：:The metabolic pathways of dietary flavonoids are still largely unknown. In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-g...

journal_title：Chemical research in toxicology

authors： Moridani MY,Scobie H,Salehi P,O'Brien PJ

更新日期：2001-07-01 00:00:00