Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1.

abstract：:Carbon disulfide (CS2) induces embryo implantation disorders. Macrophages participate in the process of pregnancy. Therefore, we want to explore the effects of CS2 exposure on polarization and immune function of macrophages in pregnant mice uteri. The exposure times were gestation days 3 (GD3), 4 (GD4), and 5 (GD5), a...

journal_title：Chemical research in toxicology

authors： Zhang T,Hu C,Wu Y,Wang S,Liu X,Zhang D,Huang F,Gao H,Wang Z

更新日期：2019-10-21 00:00:00

abstract：:It is well-known that aromatic diamino-, dihydroxy-, and amino-hydroxy compounds, with NH(2) and OH groups in ortho- or para-positions relative to each other, are strong skin sensitizers. In this paper, we analyze published potency and cross-reactivity data, whereby animals sensitized to one of these compounds are cha...

journal_title：Chemical research in toxicology

authors： Aptula AO,Enoch SJ,Roberts DW

更新日期：2009-09-01 00:00:00

abstract：:Reactive nitrogen species (RNS) are produced during infection and inflammation, and the effects of these agents on proteins, DNA, and lipids are well recognized. In contrast, the effects of RNS damaged metabolites are less appreciated. 5-Amino-3-β-(d-ribofuranosyl)-3 H-imidazo-[4,5- d][1,3]oxazine-7-one (oxanosine) an...

journal_title：Chemical research in toxicology

authors： Yu R,Kim Y,Maltseva N,Braunstein P,Joachimiak A,Hedstrom L

更新日期：2019-03-18 00:00:00

abstract：:Formyl chloride has been indirectly implicated as an intermediate in the oxidation of CH(2)Cl(2) and proposed to be a product of the oxidation of some other compounds. Formyl chloride was synthesized and added to aqueous solutions, with CO formed as a product. The presence of glutathione (GSH) did not reduce the yield...

journal_title：Chemical research in toxicology

authors： Watanabe K,Guengerich FP

更新日期：2006-08-01 00:00:00

abstract：:A methodology called quantitative component analysis of mixtures (QCAM) was used to analyze an existing set of product formulation data to determine if the irritating ingredients in the mixtures could be identified. Eye irritation scores, based on a rat model, for 18 mixtures having a composite total of 37 components,...

journal_title：Chemical research in toxicology

authors： Patel HC,Duca JS,Hopfinger AJ,Glendening CD,Thompson ED

更新日期：1999-11-01 00:00:00

abstract：:One possible mechanism linking inflammation with cancer involves the generation of reactive oxygen, nitrogen, and halogen species by activated macrophages and neutrophils infiltrating sites of infection or tissue damage, with these chemical mediators causing damage that ultimately leads to cell death and mutation. To ...

journal_title：Chemical research in toxicology

authors： Prestwich EG,Mangerich A,Pang B,McFaline JL,Lonkar P,Sullivan MR,Trudel LJ,Taghizedeh K,Dedon PC

更新日期：2013-04-15 00:00:00

abstract：:Liver microsomes from uninduced hogs catalyzed the NADPH-dependent N-oxidation of the hydroxylamine (Z)-3-(4-bromophenyl)-N-hydroxy-N-methyl-3-(3-pyridyl)allylamine. The conjugated nitrone N-[(2Z)-3-(4-bromophenyl)-3-(3-pyridyl)-2-propenylidene]methylamin e N-oxide was the principal product and accounted for 90-95% of...

journal_title：Chemical research in toxicology

authors： Cashman JR,Yang ZC,Högberg T

更新日期：1990-09-01 00:00:00

abstract：:DNA damage and mutations are a major primary cause of cancer. Chemical bombardment of DNA is a major contributor to DNA damage. The Division of Chemical Toxicology recently hosted a panel of researchers who provided updates on the field of chemical toxicology at the nexus of DNA damage and repair. ...

journal_title：Chemical research in toxicology

authors： Pathira Kankanamge LS,Perera HM,Griffin WC

更新日期：2021-01-28 00:00:00

abstract：:1,3-Butadiene (BD) is a high-volume industrial chemical and a common environmental pollutant. Although BD is classified as a "probable human carcinogen", only limited evidence is available for its tumorigenic effects in occupationally exposed populations. Animal studies show a surprisingly high sensitivity of mice to ...

journal_title：Chemical research in toxicology

authors： Tretyakova N,Sangaiah R,Yen TY,Gold A,Swenberg JA

更新日期：1997-10-01 00:00:00

abstract：:Exposure to aristolochic acid I (AAI) is associated with aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial cancer. Individual differences in xenobiotic-metabolizing enzyme activities are likely to be a reason for interindividual susceptibility to AA-induced disease. We evaluated the reductive a...

journal_title：Chemical research in toxicology

authors： Arlt VM,Levová K,Bárta F,Shi Z,Evans JD,Frei E,Schmeiser HH,Nebert DW,Phillips DH,Stiborová M

更新日期：2011-10-17 00:00:00

abstract：:While xenobiotic carboxylic acids (XCAs) have been studied extensively with respect to their enzymatic conversion to potentially reactive acyl glucuronides with implications to drug induced hepatotoxicity, the formation of xenobiotic-S-acyl-CoA thioesters (xenobiotic-CoAs) have been much less studied in spite of data ...

journal_title：Chemical research in toxicology

authors： Darnell M,Weidolf L

更新日期：2013-08-19 00:00:00

abstract：:A potentiometric and spectroscopic (UV/vis and CD) study of Cu(II) and Ni(II) binding to the N-terminal pentadecapeptide of human protamine HP2 (HP2(1-15)) was performed. The results indicate that the N-terminal tripeptide motif Arg-Thr-His is the exclusive binding site for both metal ions at a metal to HP2(1-15) mola...

journal_title：Chemical research in toxicology

authors： Bal W,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1997-08-01 00:00:00

abstract：:5'-d(CCTATAGATATCC) was reacted with each syn-enantiomer of trans-7,8-dihydroxy 9,10-epoxy 7,8,9,10-tetrahydrobenzo[a]pyrene (syn-BPDE). The (-)-enantiomer yielded one dominating adduct, whereas the (+)-enantiomer resulted in two major adducts. As indicated by optical spectroscopic methods, the major adduct derived fr...

journal_title：Chemical research in toxicology

authors： Pontén I,Seidel A,Gräslund A,Jernström B

更新日期：1996-01-01 00:00:00

abstract：:The reaction of the alpha, beta-unsaturated ketones methyl vinyl ketone (MVK) and ethyl vinyl ketone (EVK) with nucleosides and 5'-mononucleotides was studied. The genotoxic activity of MVK and EVK in the SOS Chromotest was investigated. Three different types of adducts with deoxyguanosine were found and their structu...

journal_title：Chemical research in toxicology

authors： Eder E,Hoffman C,Deininger C

更新日期：1991-01-01 00:00:00

abstract：:The kinetics and mechanisms of the hydrolysis of cysteine thiosulfinate ester (CyS(O)SCy ( x- ), x = 0-2) have been investigated by stopped-flow spectrophotometry between pH 6 and pH 14. The rate-limiting reaction of hydroxide is observed for pH < 13. More complicated kinetics are observed above pH 13, where the hydro...

journal_title：Chemical research in toxicology

authors： Nagy P,Ashby MT

更新日期：2007-09-01 00:00:00

abstract：:Caffeine on alkaline hydrolysis produces caffeidine [1-methyl-4-(methylamino)-5-(N-methylcarbamoyl)imidazole] and caffeidine acid [N-[4-(5-carboxy-1-methylimidazolyl)]-N,N'-dimethylurea]. We now report the synthesis and chemical characterization of mononitrosocaffeidine [1-methyl-4-(N-methyl-N-nitrosoamino)-5-(N-methy...

journal_title：Chemical research in toxicology

authors： Kumar R,Wacker CD,Mende P,Spiegelhalder B,Preussmann R,Siddiqi M

更新日期：1993-01-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats. PhIP is a potential human carcinogen: it undergoes metabolic activation to form electrophilic metabolites that bind to DNA and proteins, including serum albumin (SA). The structures of Ph...

journal_title：Chemical research in toxicology

authors： Peng L,Dasari S,Tabb DL,Turesky RJ

更新日期：2012-10-15 00:00:00

abstract：:Carcinogenic polycyclic aromatic hydrocarbons (PAH), e.g., benzo[a]pyrene (BaP), possess a bay region comprising an ortho-fused benzene ring. Benzo[ghi]perylene (BghiP) represents the group of PAHs lacking such a "classic" bay region and hence cannot be metabolically converted like BaP to bay region dihydrodiol epoxid...

journal_title：Chemical research in toxicology

authors： Platt KL,Grupe S

更新日期：2005-04-01 00:00:00

abstract：:Stimulated monocytes and neutrophils generate hypochlorite (HOCl) via the release of the enzyme myeloperoxidase and hydrogen peroxide. HOCl is a key bactericidal agent, but can also damage host tissue. As there is a strong link between chronic inflammation and some cancers, we have investigated HOCl damage to DNA, RNA...

journal_title：Chemical research in toxicology

authors： Hawkins CL,Davies MJ

更新日期：2002-01-01 00:00:00

abstract：:Oxidative stress is associated with the pathophysiology of many degenerative human diseases, including Alzheimer's disease, atherosclerosis, Parkinson's disease, and cancers. We discovered in our previous study that thioproline (SPro), a proline analogue, is generated in oxidant-exposed cells. With the prior observati...

journal_title：Chemical research in toxicology

authors： Ham YH,Jason Chan KK,Chan W

更新日期：2020-07-20 00:00:00

abstract：:Chlorophyllin (CHL), a food-grade derivative of the green plant pigment chlorophyll, has recently been shown in this laboratory to be a potent inhibitor in vivo of hepatic aflatoxin B1 (AFB1)-DNA adduction and hepatocarcinogenesis (Breinholt et al. (1995) Cancer Res. 55, 57-62). We report here that CHL forms a strong ...

journal_title：Chemical research in toxicology

authors： Breinholt V,Schimerlik M,Dashwood R,Bailey G

更新日期：1995-06-01 00:00:00

abstract：:Methyleugenol (ME), an alkenylbenzene compound, is a natural ingredient of several herbs and is used as flavoring agent in foodstuffs and fragrance in cosmetics. The hepatotoxicity, cytotoxicity, and carcinogenesis of ME have been well documented, and metabolic activation has been suggested to involve in ME-induced to...

journal_title：Chemical research in toxicology

authors： Feng Y,Wang H,Wang Q,Huang W,Peng Y,Zheng J

更新日期：2017-02-20 00:00:00

abstract：:Trichloroethylene (TCE), a widely used industrial solvent, is a common environmental contaminant. We previously reported that TCE-induced changes in DNA methylation and miRNA expression contributed to the development of a liver tumor in mice. In this study, we investigated the role of long intergenic noncoding RNA (Li...

journal_title：Chemical research in toxicology

authors： Ren F,Wang J,Aniagu S,Li J,Jiang Y,Chen T

更新日期：2020-06-15 00:00:00

abstract：:Drug hypersensitivity reactions adversely affect treatment outcome, increase the length of patients' hospitalization, and limit the prescription options available to physicians. In addition, late stage drug attrition and the withdrawal of licensed drugs cost the pharmaceutical industry billions of dollars. This signif...

journal_title：Chemical research in toxicology

authors： Hammond S,Thomson PJ,Ogese MO,Naisbitt DJ

更新日期：2020-01-21 00:00:00

abstract：:Iron in iron overload disease is present as non-transferrin-bound iron, consisting of iron, citrate, and albumin. We investigated the redox properties of iron citrate by electrochemistry, by the kinetics of its reaction with ascorbate, by ESR, and by analyzing the products of reactions of ascorbate with iron citrate c...

journal_title：Chemical research in toxicology

authors： Adam FI,Bounds PL,Kissner R,Koppenol WH

更新日期：2015-04-20 00:00:00

abstract：:Arylamines (AAs) and heterocyclic aromatic amines (HAAs) are structurally related carcinogens formed during the combustion of tobacco or cooking of meat. They undergo cytochrome P450 mediated N-hydroxylation to form metabolites which bind to DNA and lead to mutations. The N-hydroxylated metabolites of many AAs also ca...

journal_title：Chemical research in toxicology

authors： Pathak KV,Chiu TL,Amin EA,Turesky RJ

更新日期：2016-03-21 00:00:00

abstract：:All living organisms are exposed to xenobiotics from the environment. The exposure can lead to the formation of covalent adducts of xenobiotics or their metabolites with nucleic acids (NAs).The knowledge of NA adduct structure provides valuable information n the mechanism of carcinogenesis on a molecular level. While ...

journal_title：Chemical research in toxicology

authors： Dracínský M,Pohl R

更新日期：2015-02-16 00:00:00

abstract：:Troglitazone (TGZ), a 2,4-thiazolidinedione antidiabetic, causes hepatotoxicity in 1.9% of patients. TGZ is an inducer of, and substrate for, hepatic P450 3A. Microsomal metabolism yields a benzoquinone (TGZQ) and reactive intermediates. Kassahun et al. [Kassahun et al. (2001) Chem. Res. Toxicol. 14, 62-70] have trapp...

journal_title：Chemical research in toxicology

authors： Tettey JN,Maggs JL,Rapeport WG,Pirmohamed M,Park BK

更新日期：2001-08-01 00:00:00

abstract：:The synthesis of the 8 possible stereoisomeric diol epoxides (DEs) at the terminal benzo ring of carcinogenic dibenz[a,h]anthracene (DBA) is reported. trans-3,4-Dihydroxy-3,4-dihydro-DBA (1) afforded the 4 bay region DEs: the enantiomeric pairs of the anti diastereomers (+)-3/(-)-3 and of the syn diastereomers (-)-4/(...

journal_title：Chemical research in toxicology

authors： Frank H,Funk M,Oesch F,Platt KL

更新日期：2011-12-19 00:00:00

abstract：:Thioredoxin reductase (TR), an NADPH-dependent flavoenzyme that catalyzes the reduction of many disulfide-containing substrates, plays an important role in the cellular response to oxidative stress. Trivalent arsenicals, especially methyl As that contains trivalent arsenic (MAs(III)), are potent noncompetitive inhibit...

journal_title：Chemical research in toxicology

authors： Lin S,Del Razo LM,Styblo M,Wang C,Cullen WR,Thomas DJ

更新日期：2001-03-01 00:00:00