当前位置： SCI文献检索 > CHEMICAL RESEARCH IN TOXICOLOGY期刊下所有文献 > Subchronic toxicity and cardiovascular responses in spontaneously hypertensive rats after exposure to multiwalled carbon nanotubes by intratracheal instillation.

Subchronic toxicity and cardiovascular responses in spontaneously hypertensive rats after exposure to multiwalled carbon nanotubes by intratracheal instillation.

Abstract：

:The tremendous demand of the market for carbon nanotubes has led to their massive production that presents an increasing risk through occupational exposure. Lung deposition of carbon nanotubes is known to cause acute localized pulmonary adverse effects. However, systemic cardiovascular damages associated with acute pulmonary lesion have not been thoroughly addressed. Four kinds of multiwalled carbon nanotubes (MWCNTs) with different lengths and/or iron contents were used to explore the potential subchronic toxicological effects in spontaneously hypertensive (SH) rats and normotensive control Wistar-Kyoto (WKY) rats after intratracheal instillation. MWCNTs penetrated the lung blood-gas barrier and accumulated in the liver, kidneys, and spleen but not in the heart and aorta of SH rats. The pulmonary toxicity and cardiovascular effects were assessed at 7 and 30 days postexposure. Compared to the WKY rats, transient influences on blood pressure and up to 30 days persistent decrease in the heart rate of SH rats were found by electrocardiogram monitoring. The subchronic toxicity, especially the sustained inflammation of the pulmonary and cardiovascular system, was revealed at days 7 and 30 in both SH and WKY rat models. Histopathological results showed obvious morphological lesions in abdominal arteries of SH rats 30 days after exposure. Our results suggest that more attention should be paid to the long-term toxic effects of MWCNTs, and particularly, occupationally exposed workers with preexisting cardiovascular diseases should be monitored more thoroughly.

journal_name

Chem Res Toxicol

journal_title

Chemical research in toxicology

authors

Chen R,Zhang L,Ge C,Tseng MT,Bai R,Qu Y,Beer C,Autrup H,Chen C

doi

10.1021/tx5004003

subject

Has Abstract

pub_date

2015-03-16 00:00:00

pages

440-50

issue

3

eissn

0893-228X

issn

1520-5010

journal_volume

28

pub_type

杂志文章

相关文献

CHEMICAL RESEARCH IN TOXICOLOGY文献大全
  • Miscoding by the exocyclic and related DNA adducts 3,N4-etheno-2'-deoxycytidine, 3,N4-ethano-2'-deoxycytidine, and 3-(2-hydroxyethyl)-2'-deoxyuridine.

    abstract：:3,N4-Etheno-2'-deoxycytidine, 3-(hydroxyethyl)-2'-deoxyuridine, and 3,N4-ethano-2'-deoxy-cytidine are found in DNA of cells treated with either vinyl chloride or 1,3-bis(2-chloroethyl)-nitrosourea. These exocyclic and related DNA adducts were incorporated into oligodeoxynucleotides, which were then used as templates f...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00043a021

    authors： Zhang W,Johnson F,Grollman AP,Shibutani S

    更新日期：1995-01-01 00:00:00

  • Hydrolytic Cleavage Products of Globin Adducts in Urine as Possible Biomarkers of Cumulative Dose: Proof of Concept Using Styrene Oxide as a Model Adduct-Forming Compound.

    abstract：:A new experimental model was designed to study the fate of globin adducts with styrene 7,8-oxide (SO), a metabolic intermediate of styrene and a model electrophilic compound. Rat erythrocytes were incubated with SO at 7 or 22 °C. Levels of specific amino acid adducts in globin were determined by LC/MS analysis of the ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.5b00518

    authors： Mráz J,Hanzlíková I,Moulisová A,Dušková Š,Hejl K,Bednářová A,Dabrowská L,Linhart I

    更新日期：2016-04-18 00:00:00

  • Selective inhibition of cytochrome P450 2E1 in vivo and in vitro with trans-1,2-dichloroethylene.

    abstract：:The effect of trans-1,2-dichloroethylene (DCE), an inhibitor of cytochrome P450 (P450) 2E1, on the catalytic activities and total content of hepatic P450 was determined in vivo and in vitro. Hepatic microsomes were prepared from groups of rats prior to dosing and at 2, 5, 12, and 24 h postdosing, and total P450 conten...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx970227g

    authors： Mathews JM,Etheridge AS,Raymer JH,Black SR,Pulliam DW Jr,Bucher JR

    更新日期：1998-07-01 00:00:00

  • (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins.

    abstract：:Free-radical oxidation of human plasma low-density lipoprotein (LDL) produces (carboxyalkyl)pyrrole (CAP) epitopes that were detected with enzyme-linked immunosorbent assays using antibodies raised against keyhole limpet hemocyanin (KLH)-bound 2-(omega-carboxyheptyl)-pyrrole (CHP) and 2-(omega-carboxypropyl)pyrrole (C...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx970112c

    authors： Kaur K,Salomon RG,O'Neil J,Hoff HF

    更新日期：1997-12-01 00:00:00

  • A kinetic model of the cell culture cytotoxicity of metabolically activated agents: N-methyl-N-(acetoxymethyl)nitrosamine, methylnitrosourethane, and (methylazoxy)methanol acetate.

    abstract：:The activity of three metabolically activated methylating agents, N-methyl-N-(acetoxymethyl)nitrosamine (DMN-OAc), methylnitrosourethane (MNUT), and (methylazoxy)methanol acetate (MAM-Ac), were determined in cell culture by using a P388 cell growth rate inhibition assay. Experiments were conducted with normal P388 cel...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00011a004

    authors： Weinkam RJ,Plakunov I

    更新日期：1989-09-01 00:00:00

  • Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.

    abstract：:O6-Benzyl-2'-deoxyguanosine is a potential antitumor drug modulator that is intended to reduce or eliminate O6-alkylguanine-DNA alkyltransferase activity in tumors prior to treatment with genotoxic chemotherapeutic alkylating agents. The rationale for using this compound instead of the more active O6-benzylguanine and...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00042a008

    authors： Kokkinakis DM,Moschel RC,Pegg AE,Dolan ME,Schold SC Jr

    更新日期：1994-11-01 00:00:00

  • Biotransformation Mechanism of Pesticides by Cytochrome P450: A DFT Study on Dieldrin.

    abstract：:Pesticide biotransformation, especially by cytochrome P450 enzymes (CYPs), may produce metabolites with substantially altered toxicological and physicochemical profiles, which has drawn great attention as a basis for environmental risk assessment. CYPs are active in the metabolism of various reactions of pesticides, a...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.0c00013

    authors： Chai L,Ji S,Zhang S,Yu H,Zhao M,Ji L

    更新日期：2020-06-15 00:00:00

  • Formation of glutathionyl-spironolactone disulfide by rat liver cytochromes P450 or hog liver flavin-containing monooxygenases: a functional probe of two-electron oxidations of the thiosteroid?

    abstract：:We have previously reported that the diuretic thiosteroid spironolactone (SPL) inactivates rat liver microsomal cytochromes P450 [P450 (P450 3A and P450 2C11)] in a in a mechanism-based fashion, and we have identified two polar SPL metabolites (SPL-sulfinic acid and -sulfonic acid), formed in a partition ratio of appr...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00024a012

    authors： Decker CJ,Cashman JR,Sugiyama K,Maltby D,Correia MA

    更新日期：1991-11-01 00:00:00

  • Potentialities and pitfalls accompanying chemico-pharmacological strategies against endogenous electrophiles and carbonyl stress.

    abstract：:The use of powerful analytical technologies to detect endogenous carbonyls formed as byproducts of oxidative cell injury has revealed that these species contribute to many human diseases. As electrophiles, they are attacked by reactive centers in cell macromolecules to form adducts, the levels of which serve as useful...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700399q

    authors： Burcham PC

    更新日期：2008-04-01 00:00:00

  • Quantitative component analysis of mixtures for risk assessment: application to eye irritation.

    abstract：:A methodology called quantitative component analysis of mixtures (QCAM) was used to analyze an existing set of product formulation data to determine if the irritating ingredients in the mixtures could be identified. Eye irritation scores, based on a rat model, for 18 mixtures having a composite total of 37 components,...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx990098z

    authors： Patel HC,Duca JS,Hopfinger AJ,Glendening CD,Thompson ED

    更新日期：1999-11-01 00:00:00

  • Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats.

    abstract：:Our long-term oral administration of dimethylarsinic acid (DMAV) in rats revealed that three unidentified metabolites, M-1, M-2, and M-3, were detected in urine and feces. DMAV and trimethylarsine oxide (TMAO) were converted to M-2 and M-3 and M-1 by Escherichia coli strain A3-6 isolated from the ceca of DMAV-administ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx030008x

    authors： Yoshida K,Kuroda K,Zhou X,Inoue Y,Date Y,Wanibuchi H,Fukushima S,Endo G

    更新日期：2003-09-01 00:00:00

  • Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells.

    abstract：:The purpose of this study was to investigate the degree of chlorination of catechol (CAT) derivatives of pentachlorophenol (PCP) on the induction of cytotoxicity and DNA damaging effects in calf thymus DNA (ct-DNA) and in two human breast carcinoma cell lines. Results indicated that with the addition of the transition...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0498511

    authors： Lin CH,Leow HT,Huang SC,Nakamura J,Swenberg JA,Lin PH

    更新日期：2005-02-01 00:00:00

  • Radicals derived from histone hydroperoxides damage nucleobases in RNA and DNA.

    abstract：:Exposure of individual histone proteins (H1, H2A, H2B, H3, or H4) and histone octamers (consisting of two molecules each of H2A, H2B, H3, and H4) to hydroxyl radicals, generated by gamma-irradiation, in the presence of O(2) generates protein-bound hydroperoxides in a dose-dependent fashion; this is in accord with prev...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx000053u

    authors： Luxford C,Dean RT,Davies MJ

    更新日期：2000-07-01 00:00:00

  • Mechanisms of nitrogen oxide-mediated disruption of metalloprotein function: an examination of the copper-responsive yeast transcription factor Ace1.

    abstract：:Nitric oxide (NO) has been found to inhibit the copper-responsive yeast transcription factor Ace1 in an oxygen-dependent manner. However, the mechanism responsible for NO-dependent inhibition of Ace1 remains unestablished. In the present study, the chemical interaction of nitrogen oxide species with Ace1 was examined ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx010102i

    authors： Shinyashiki M,Pan CJ,Switzer CH,Fukuto JM

    更新日期：2001-12-01 00:00:00

  • Identification and Profiling of Environmental Chemicals That Inhibit the TGFβ/SMAD Signaling Pathway.

    abstract：:The transforming growth factor beta (TGFβ) superfamily of secreted signaling molecules and their cognate receptors regulate cell fate and behaviors relevant to many developmental and disease processes. Disruption of TGFβ signaling during embryonic development can, for example, affect morphogenesis and differentiation ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.9b00228

    authors： Wei Z,Sakamuru S,Zhang L,Zhao J,Huang R,Kleinstreuer NC,Chen Y,Shu Y,Knudsen TB,Xia M

    更新日期：2019-12-16 00:00:00

  • Reactions of amino acids, peptides, and proteins with oxidized metabolites of tris(p-carboxyltetrathiaaryl)methyl radical EPR probes.

    abstract：:Oxidation of the tris(p-carboxyltetrathiaaryl)methyl (TAM) EPR radical probe, TAMa(•), by rat liver microsomes (RLM) + NADPH, or horseradish peroxidase (HRP) + H2O2, or K2IrCl6, led to an intermediate cation, TAMa(+), which was treated with glutathione (GSH), with formation of an adduct, TAMa-SG(•), resulting from the...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx400467p

    authors： Decroos C,Boucher JL,Mansuy D,Xu-Li Y

    更新日期：2014-04-21 00:00:00

  • Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.

    abstract：:Flucloxacillin, an isoxazolyl-penicillin, causes cholestasis and biliary epithelium injury. The aim of the study was to determine whether flucloxacillin, either directly or through metabolite formation, may induce cytotoxicity in hepatic or biliary cells. Cytotoxicity was assessed by lactate dehydrogenase release in p...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0002435

    authors： Lakehal F,Dansette PM,Becquemont L,Lasnier E,Delelo R,Balladur P,Poupon R,Beaune PH,Housset C

    更新日期：2001-06-01 00:00:00

  • Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

    abstract：:The tobacco-specific nitrosamines N'-nitrosonornicotine (NNN, 1) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents. Bioactivation of NNN and NNK by cytochrome P450 enzymes generates a pyridyloxobutylating agent 6, which alkylates DNA to produce pyridyloxobutyl (POB)-DNA addu...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx050351x

    authors： Lao Y,Villalta PW,Sturla SJ,Wang M,Hecht SS

    更新日期：2006-05-01 00:00:00

  • Protein modification by acrolein: formation and stability of cysteine adducts.

    abstract：:The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation. Potential acrolein targets in protein include the nucleophilic side chains of cysteine, histi...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx800465m

    authors： Cai J,Bhatnagar A,Pierce WM Jr

    更新日期：2009-04-01 00:00:00

  • Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

    abstract：:The recent guidance on "Safety Testing of Drug Metabolites" issued by the U.S. Food and Drug Administration, Center for Drug Evaluation and Research (CDER) has highlighted the importance of identifying and characterizing drug metabolites as early as possible in drug discovery and development. Furthermore, upon identif...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx8003328

    authors： Vishwanathan K,Babalola K,Wang J,Espina R,Yu L,Adedoyin A,Talaat R,Mutlib A,Scatina J

    更新日期：2009-02-01 00:00:00

  • Characterization of a lipid hydroperoxide-derived RNA adduct in rat intestinal epithelial cells.

    abstract：:Five major products (adducts A(1a), A(1b), A(2), A(3,) and B) from the reaction of guanosine (Guo) with 4-oxo-2(E)-nonenal (ONE) were detected by liquid chromatography-mass spectrometry (LC-MS). Tandem MS (MS/MS) analysis of these compounds suggested that modifications to the nucleoside had been introduced. Adducts A(...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0600189

    authors： Zhu P,Lee SH,Wehrli S,Blair IA

    更新日期：2006-06-01 00:00:00

  • Identification and characterization of a reaction product of 2'-deoxyoxanosine with glycine.

    abstract：:2'-Deoxyoxanosine (dOxo) is a novel DNA lesion produced from dGuo by reaction with nitrous acid or nitric oxide [Suzuki, T., Yamaoka, R., Nishi, M., Ide, H., and Makino, K. (1996) J. Am. Chem. Soc. 118, 2515-2516]. We investigated the reaction of dOxo with glycine (Gly) under physiological conditions. When 5 mM dOxo w...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx990164x

    authors： Suzuki T,Yamada M,Ide H,Kanaori K,Tajima K,Morii T,Makino K

    更新日期：2000-04-01 00:00:00

  • Mechanism of cytochrome P450-catalyzed aromatic hydroxylation of estrogens.

    abstract：:The mechanism of aromatic hydroxylation of estrogens by cytochrome P450 enzymes has been examined by comparing the oxidation of estrone with that of substrates carrying additional aromaticity such as equilenin and the structural analog 2-naphthol. Hamster liver microsomes preferentially catalyzed the conversion of est...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx970021f

    authors： Sarabia SF,Zhu BT,Kurosawa T,Tohma M,Liehr JG

    更新日期：1997-07-01 00:00:00

  • The mechanism of the peroxynitrite-mediated oxidation of myoglobin in the absence and presence of carbon dioxide.

    abstract：:Among the cellular components that can react directly with peroxynitrite in the presence of physiological CO(2) concentrations are sulfur-, selenium-, and metal-containing proteins, in particular hemoproteins. We have previously shown that the reactions of peroxynitrite with oxymyoglobin (MbFeO(2)) and oxyhemoglobin p...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx025595l

    authors： Herold S,Exner M,Boccini F

    更新日期：2003-03-01 00:00:00

  • Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.

    abstract：:Structure-function relationships for the inhibition of human cytochrome P450s (P450s) 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives were studied. Thirty-two of the 33 flavonoids tested produced reverse type I binding spectra with P450 1B1, and the potencies of binding were correlated with the abilities to in...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx100286d

    authors： Shimada T,Tanaka K,Takenaka S,Murayama N,Martin MV,Foroozesh MK,Yamazaki H,Guengerich FP,Komori M

    更新日期：2010-12-20 00:00:00

  • A Novel Lipidomics-Based Approach to Evaluating the Risk of Clinical Hepatotoxicity Potential of Drugs in 3D Human Microtissues.

    abstract：:The importance of adsorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis is expected to grow substantially due to recent failures in detecting severe toxicity issues of new chemical entities during preclinical/clinical development. Traditionally, safety risk assessment studies for humans have b...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.9b00364

    authors： Goracci L,Valeri A,Sciabola S,Aleo MD,Moritz W,Lichtenberg J,Cruciani G

    更新日期：2020-01-21 00:00:00

  • Ring addition of the alpha-amino group of glutathione increases the reactivity of benzoquinone thioethers.

    abstract：:2-(Glutathion-S-yl)-1,4-benzoquinone was found to be remarkably unstable in phosphate buffer (pH 7.4) even in the absence of oxygen. Intramolecular addition of the alpha-amino group of the glutamate residue to the quinone ring yielded ultimately 2,3-(glutathion-N, S-yl)-1,4-benzoquinone and 2,6-(glutathion-N,S-yl)-1,4...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx9800699

    authors： Alt C,Eyer P

    更新日期：1998-10-01 00:00:00

  • Organophosphorus pesticide chlorpyrifos and its metabolites alter the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells in a comparable way to other model neurodevelopmental toxicants.

    abstract：:There are discrepancies about whether chlorpyrifos is able to induce neurodevelopmental toxicity or not. We previously reported alterations in the pattern of expression of biomarker genes of differentiation in D3 mouse embryonic stem cells caused by chlorpyrifos and its metabolites chlorpyrifos-oxon and 3,5,6-trichlor...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx500051k

    authors： Estevan C,Fuster E,Del Río E,Pamies D,Vilanova E,Sogorb MA

    更新日期：2014-09-15 00:00:00

  • Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1α stabilization in colon carcinoma cells.

    abstract：:Hypoxia-inducible factor-1α (HIF-1α) is a critical regulator of cellular responses to hypoxia. Under normoxic conditions, the cellular HIF-1α level is regulated by hydroxylation by prolyl hydroxylases (PHDs), ubiquitylation, and proteasomal degradation. During hypoxia, degradation decreases, and its intracellular leve...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx300274a

    authors： Chowdhury R,Godoy LC,Thiantanawat A,Trudel LJ,Deen WM,Wogan GN

    更新日期：2012-10-15 00:00:00

  • Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane.

    abstract：:Formyl chloride has been indirectly implicated as an intermediate in the oxidation of CH(2)Cl(2) and proposed to be a product of the oxidation of some other compounds. Formyl chloride was synthesized and added to aqueous solutions, with CO formed as a product. The presence of glutathione (GSH) did not reduce the yield...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx060087n

    authors： Watanabe K,Guengerich FP

    更新日期：2006-08-01 00:00:00