Abstract:
:The purpose of this study was to assess the impact of 3 months of aromatase inhibition together with progestin add-back on ovarian endometrioma size. This prospective cohort study was performed at University Medical Center (UC San Diego). Women trying to conceive were excluded. After informed consent, all women were treated with the aromatase inhibitor letrozole (5 mg/d) with norethindrone acetate (5 mg/d) add-back for 3 months. Pre- and posttreatment assessments of endometrioma sizes were performed by ultrasound. The impact of treatment on pain was determined using the patient assessed endpoints of the Biberoglu and Behrman scale. These included assessing dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain each on a scale from 0 to 3. The primary endpoint of this study was the change in ultrasound documented endometrioma size. Fourteen endometriomas in 8 consecutive women were treated for 3 m. Mean endometrioma diameter decreased 50% from 4.6 ± 1.6 cm to 2.3 ± 1.6 cm (mean ± SD). This represents a 75% decrease in endometrioma volume. Endometriosis symptoms of dysmenorrhea, dyspareunia, and nonmenstrual pelvic pain also improved with treatment. In conclusion, a 3-month course of high dose aromatase inhibition with progestin add-back significantly reduces ovarian endometrioma size and warrants further investigation.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Agarwal SK,Foster WGdoi
10.1155/2015/878517subject
Has Abstractpub_date
2015-01-01 00:00:00pages
878517eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
临床试验,杂志文章abstract::Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is a mitochondrial inner membrane protein and plays an important role in mitochondrial ATP production and biogenesis. High expression levels of LETM1 have been correlated with numerous human malignancies. This study explored the clinicopathological sign...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/850316
更新日期:2014-01-01 00:00:00
abstract::Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by an impairment of corneal sensory innervation, characterized by decreased or absent corneal sensitivity resulting in epithelial keratopathy, ulceration, and perforation. The aetiopathogenesis of corneal sensory innervation impairment in ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/805876
更新日期:2015-01-01 00:00:00
abstract::Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/941764
更新日期:2013-01-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer. Inducible nitric oxide synthase (iNOS) and p53 are associated with a variety of human cancers, but their expression and interaction in OSCC have not been fully explored. In this study, we investigated the expression of iNOS and p53 in OSCC ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/637853
更新日期:2015-01-01 00:00:00
abstract:Background:Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectab...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6278403
更新日期:2018-08-27 00:00:00
abstract::Few studies assess agreement among Schistosoma haematobium eggs, measured hematuria, and self-reported metrics. We assessed agreement among four metrics at a single time point and analyzed the stability of infection across two time points with a single metric. We used data from the Eastern Region of Ghana and construc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7627358
更新日期:2016-01-01 00:00:00
abstract::ACE inhibitory dipeptides from Xerocomus badius fermented shrimp processing waste were isolated with ethanol, macroporous resin, chloroform, and Sephadex G-10 in sequence and identified by LC-MS/MS system coupled with electrospray ionization source. Molecular docking was performed for exploring the mechanism of their ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5089270
更新日期:2018-05-08 00:00:00
abstract::Perinatal infections have a negative impact on brain development. However, the underlying mechanisms leading to neurological impairment are not completely understood and reliable models of inflammation are urgently needed. Using phorbol-myristate-acetate as an activator of inflammation, we investigated the effect on t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/318306
更新日期:2015-01-01 00:00:00
abstract::The incidence of postoperative nausea and vomiting (PONV) is 30-50% after surgery. PONV occurs frequently, especially after craniotomy. In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant, a neurokinin-1 (NK1) receptor antago...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/307025
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship of delivery type, maternal anesthesia, feeding modalities, and first feeding and meconium passage times with early bilirubin levels of healthy infants. METHODS:Cord, 24 hours' and 48 hours' total bilirubin levels were measured in 388 study infants. RESULTS:Infants born with c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/316430
更新日期:2013-01-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder with core impairments in the social relationships, communication, imagination, or flexibility of thought and restricted repertoire of activity and interest. In this work, a new computer aided diagnosis (CAD) of autism based on electroencephalogra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9816591
更新日期:2017-01-01 00:00:00
abstract::Newcastle disease (ND) is one of the most devastating diseases that considerably cripple the global poultry industry. Because of its enormous socioeconomic importance and potential to rapidly spread to naïve birds in the vicinity, ND is included among the list of avian diseases that must be notified to the OIE immedia...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/7278459
更新日期:2018-08-05 00:00:00
abstract::Early Infantile Epileptic Encephalopathy (known as Ohtahara Syndrome) is one of the most severe and earliest forms of epilepsy, characterized by early seizures onset. It affects newborns and children between two and six years old. Among the genes that have been associated with early infantile epileptic encephalopathy,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4872101
更新日期:2019-12-17 00:00:00
abstract:Aims:The purpose of this study was to describe the challenge of cross-cultural care encounters from perspective of imported nurses in Lhasa, Tibet, as well as investigate the relationship of cross-cultural care encounters and its influencing factors. Methods:A cross-sectional survey was designed among 300 imported nur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3159178
更新日期:2020-04-08 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease. NAFLD encompasses a wide range of pathologies, from simple steatosis to steatosis with inflammation to fibrosis. The pathogenesis of NAFLD progression has not been completely elucidated, and different liver cells could be imp...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/768071
更新日期:2015-01-01 00:00:00
abstract::Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anat...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/684127
更新日期:2014-01-01 00:00:00
abstract::We have developed a new "drug" and approach that appear to be effective in reducing arterial age. This "drug" represents a low, subtherapeutic dose of statin and sartan and particularly their low-dose combination. The improvement of arterial wall characteristics, also reflecting in a decrease of arterial age, was achi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/235709
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The present study investigated which type of adenocarcinoma with BAC features was prone to be false-negative on 18F-FDG PET/CT. MATERIALS AND METHODS:A retrospective study was performed on 51 consecutive patients with localized adenocarcinoma with BAC features. CT and PET were assessed for lesion size, GGO per...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243681
更新日期:2015-01-01 00:00:00
abstract::Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 (EZR-AS1) is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6840234
更新日期:2020-05-22 00:00:00
abstract:PURPOSE:This study aimed to investigate the shear displacement between the body and backrest/seat, range of motion (ROM), and force acting on the lower limb joints during sit-stand-sit transitions by operating an electric-powered standing wheelchair. METHODS AND MATERIALS:The amounts of sliding along the backrest and ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/236486
更新日期:2014-01-01 00:00:00
abstract::Dietary polyphenols present in a broad range of plant foods have been related to beneficial health effects. This review aims to update the current information about the modulation of the gut microbiota by dietary phenolic compounds, from a perspective based on the experimental approaches used. After referring to gener...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/850902
更新日期:2015-01-01 00:00:00
abstract::During vertebrate development, the lung inaugurates as an endodermal bud from the primitive foregut. Dichotomous subdivision of the bud results in arborizing airways that form the prospective gas exchanging chambers, where a thin blood-gas barrier (BGB) is established. In the mammalian lung, this proceeds through conv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/101597
更新日期:2013-01-01 00:00:00
abstract::Breast cancer is the most frequently occurring disease among women worldwide. The early stage of breast cancer identification is the key challenge in cancer control and prevention procedures. Although gene expression profiling helps to understand the molecular mechanism of diseases or disorder in the living system, ge...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3071013
更新日期:2016-01-01 00:00:00
abstract:Objective:Our aim was the development and validation of a modular signal processing and classification application enabling online electroencephalography (EEG) signal processing on off-the-shelf mobile Android devices. The software application SCALA (Signal ProCessing and CLassification on Android) supports a standardi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3072870
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The use of unlicensed food and herbal supplements to enhance sexual functions is drastically increasing. This phenomenon, combined with the availability of these products over the Internet, represents a challenge from a clinical and a public health perspective. METHODS:A comprehensive multilingual assessm...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841798
更新日期:2014-01-01 00:00:00
abstract::Introduction. The lateral lumbar interbody fusion (LLIF) surgical approach has potential advantages over other approaches but is associated with some unique neurologic risks due to the proximity of the lumbosacral plexus. The present study analyzed complications following LLIF surgical approach using a novel single fl...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2016/8450712
更新日期:2016-01-01 00:00:00
abstract::Beta-1,3-glucanosyltransferase (Gas1p) plays important roles in cell wall biosynthesis and morphogenesis and has been implicated in DNA damage responses and cell cycle regulation in fungi. Yeast Gas1p has also been reported to participate in endoplasmic reticulum (ER) stress responses. However, the precise roles and m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1238581
更新日期:2019-06-02 00:00:00
abstract::Cystic change in metastatic lymph nodes of papillary thyroid carcinoma (PTC) is a diagnostic challenge for fine needle aspiration (FNA) because of the scant cellularity. The aim of this study was to evaluate the measurement of thyroglobulin in fine needle aspirate (Tg-FNA) for detecting metastatic PTC in patients with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8905916
更新日期:2016-01-01 00:00:00
abstract::Many topical agents are available for treating the acute phase of acne; however, few agents have been proven beneficial during the maintenance phase. Objective. To evaluate the efficacy and safety of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid during the maintenance phase of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2857812
更新日期:2020-10-16 00:00:00
abstract::Two fullerene derivatives (fullerenes 1 and 2), bearing a hydrophilic chain on the pyrrolidinic nitrogen, were developed with the aim to deliver anticancer agents to solid tumors. These two compounds showed a significantly different behaviour on human neoplastic cell lines in vitro in respect to healthy leukocytes. In...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/915130
更新日期:2015-01-01 00:00:00