当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Broad-spectrum bactericidal activity of a new bioactive grafting material (F18) against clinically important bacterial strains.

Broad-spectrum bactericidal activity of a new bioactive grafting material (F18) against clinically important bacterial strains.

Abstract：

:Infection is the most relevant surgical complication in implant or grafting procedures. Osteomyelitis and other chronic conditions pose a constant challenge in current medical practice. In this context, a grafting biomaterial that possesses antibacterial properties combined with bioactivity could have great clinical impact. Researchers at the Vitreous Materials Laboratory (LaMaV-UFSCar) recently developed a glass composition, named F18, that presents an improved workability range combined with high bioactivity. With F18, one can easily manufacture complex shapes, such as scaffolds, continuous fibres and coat implants. This biomaterial has proven to be a viable alternative for bone and skin regeneration in in vivo tests, however its antimicrobial properties have not been explored. Hence, the purpose of this study was to systematically investigate the antibacterial activity of F18 in powder and fibre forms according to the JIS Z 2801:2010 standard. Whether incorporation of silver into F18 glass could impact its antimicrobial activity was also evaluated. Four clinically relevant Gram-positive and Gram-negative pathogenic bacterial strains (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa) were used in this study. In both powder and fibre forms, F18 presented extremely efficient bactericidal activity against all strains tested, eliminating virtually 100% of the bacterial cells after 24 h. Kinetic tests showed that silver doping further increased the bactericidal activity, leading to S. aureus eradication in only 30 min after incubation. Both doped and non-doped glasses demonstrated very high bactericidal activity, making F18 a promising infection-preventing alternative for bone and wound regeneration in clinical practice.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Souza MT,Campanini LA,Chinaglia CR,Peitl O,Zanotto ED,Souza CWO

doi

10.1016/j.ijantimicag.2017.08.015

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

730-733

issue

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(17)30307-2

journal_volume

pub_type

杂志文章

在线工具

Broad-spectrum bactericidal activity of a new bioactive grafting material (F18) against clinically important bacterial strains.