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Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters.

Abstract：

:We studied an in vitro model of continuous venovenous haemofiltration to determine levofloxacin adsorption by polyacrylonitrile (PAN) filters. Four doses of levofloxacin (5, 25, 50 and 100 mg) were used, resulting in circulating concentrations of levofloxacin at 120 min of 3.56+/-0.14, 15.84+/-2.08, 31.42+/-1.95 and 58.23+/-1.10 mg/L, respectively. Adsorption at 2 h was 0.65+/-0.17, 5.99+/-2.49, 12.30+/-2.34 and 30.13+/-1.32 mg, respectively (P<0.001). From 2h to 4h, increasing the blood pump rate and the ultrafiltration rate had no effect on adsorption. When the concentration was decreased from 3.55+/-0.13 mg/L at 4h to 2.16+/-0.11 mg/L at 5 h by addition of lactated Ringer's solution, adsorption decreased from 0.67+/-0.16 mg to 0.21+/-0.25 mg (P<0.05). These data show that adsorption of levofloxacin by PAN haemofilters is concentration dependent and reversible in vitro and suggest that adsorption by haemofilters is unlikely to affect levofloxacin pharmacokinetics significantly in vivo.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Tian Q,Gomersall CD,Wong A,Leung P,Choi G,Joynt GM,Tan P,Lipman J

doi

10.1016/j.ijantimicag.2006.03.025

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

147-50

issue

2

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(06)00203-2

journal_volume

28

pub_type

杂志文章

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