Effectiveness of tolvaptan monotherapy and low-dose furosemide/tolvaptan combination therapy for hepatoprotection and diuresis in a rat cirrhotic model.

abstract：:The aim of the study was to evaluate the anti-obesity effects of two types of meju in diet induced obese C57BL/6J mice. Animals were randomly divided into 4 dietary group (n = 10); normal diet, high fat diet with 30% soybean, high fat diet with 30% traditional meju, high fat diet with 30% standardized meju. After 16 w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Bae CR,Kwon DY,Cha YS

更新日期：2014-01-01 00:00:00

abstract：:Omega-3 fatty acids intake is important to maintain muscle mass. However, the relationship between omega-3 fatty acids intake and sarcopenia in elderly patients with type 2 diabetes has been unclear. We used the brief-type self-administered diet history questionnaire for the assessment of habitual food and nutrient in...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamura T,Hashimoto Y,Miki A,Kaji A,Sakai R,Iwai K,Osaka T,Ushigome E,Hamaguchi M,Yamazaki M,Fukui M

更新日期：2020-05-01 00:00:00

abstract：:Although some studies have indicated a correlation between Helicobacter pylori infection and the risk of colorectal neoplasms, these findings have not been consistent and are controversial. This case-control study aimed to investigate the association between endoscopic gastric mucosal atrophy and colorectal polyp occu...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kawahara Y,Kodama M,Mizukami K,Saito T,Hirashita Y,Sonoda A,Fukuda K,Matsunari O,Okamoto K,Ogawa R,Okimoto T,Murakami K

更新日期：2019-09-01 00:00:00

abstract：:The relationship between Helicobacter pylori (H. pylori) eradication therapy and the risk of developing gastroesophageal reflux disease (GERD) is controversial. We investigated the influence of H. pylori eradication on the risk of GERD by focusing on the quality of life (QOL) and evaluating reflux symptoms. Patients w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hirata K,Suzuki H,Matsuzaki J,Masaoka T,Saito Y,Nishizawa T,Iwasaki E,Fukuhara S,Okada S,Hibi T

更新日期：2013-03-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of antioxidant biofactor (AOB) on reactive oxygen species (ROS). Generation of superoxide radical (O(2) (•-)) and hydroxyl radical ((•)OH) was determined using an electron spin resonance (ESR) spin-trapping method. AOB was added at different concentrations to th...

journal_title：Journal of clinical biochemistry and nutrition

authors： Matsui S,Tsujimoto Y,Ozawa T,Matsushima K

更新日期：2011-05-01 00:00:00

abstract：:The effects of topical application of Rafflesia hasseltii buds and flowers extract on the rate of wound healing and histology of healed wound were assessed. Four groups of adult male Sprague Dawley rats were experimentally wounded in the posterior neck area. A thin layer of blank placebo was applied topically to wound...

journal_title：Journal of clinical biochemistry and nutrition

authors： Abdulla MA,Ahmed KA,Ali HM,Noor SM,Ismail S

更新日期：2009-11-01 00:00:00

abstract：:Reduced coenzyme Q(10) (CoQ(10)H(2)) is known as a potent antioxidant in biological systems. However, it is not yet known whether CoQ(9)H(2) could act as an antioxidant in human cells. The aim of this study is to assess whether exogenously added CoQ(9) can protect human liver cells against injuries induced by a water-...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kusumoto C,Kinugawa T,Morikawa H,Teraoka M,Nishida T,Murawaki Y,Yamada K,Matsura T

更新日期：2010-05-01 00:00:00

abstract：:Imbalance between reactive oxygen species generation and antioxidant capacity induces a condition known as oxidative stress which is implicated in numerous pathological processes. In this study we evaluated whether natural zeolites chabazite/phillipsite/analcime may affect the levels of different antioxidant enzymes (...

journal_title：Journal of clinical biochemistry and nutrition

authors： Dogliotti G,Malavazos AE,Giacometti S,Solimene U,Fanelli M,Corsi MM,Dozio E

更新日期：2012-05-01 00:00:00

abstract：:It has been reported that levels of soluble intercellular adhesion molecule-1 (ICAM-1) in the blood are elevated in hepatocellular carcinoma patients. In the present study, serial observations of the localization of ICAM-1 in the liver were made by light and electron microscopy in rats with carcinogen-induced cancer. ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Matsuoka S,Matsumura H,Arakawa Y,Nakamura H,Nirei K,Yamagami H,Ogawa M,Nakajima N,Amaki S,Tanaka N,Moriyama M

更新日期：2009-09-01 00:00:00

abstract：:Colon cancer prevalence is high worldwide. O-GlcNAcylation has been associated with tumor growth in various tissues, including the colon; however, its link to carcinogenesis is not fully understood. We investigated the association of O-GlcNAcylation with colon carcinogenesis using a 1,2-dimethylhydrazine/dextran sodiu...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hirata Y,Nakagawa T,Moriwaki K,Koubayashi E,Kakimoto K,Takeuchi T,Inoue T,Higuchi K,Asahi M

更新日期：2018-05-01 00:00:00

abstract：:Anti-peptic and anti-inflammatory actions of ecabet sodium might be beneficial in either improving gastritis or relieving dyspeptic symptoms. This study was designed to evaluate the clinical efficacy of ecabet sodium on dyspeptic symptoms and to elucidate the molecular mechanism attributable to symptom relief in patie...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yang Kim H,Hahm KB,Choi MG,Rew JS,Seol SY,Chun HJ,Lee OY,Hong WS

更新日期：2007-11-01 00:00:00

abstract：:Carnitine is a vitamin-like compound that plays important roles in fatty acid β-oxidation and the control of the mitochondrial coenzyme A/acetyl-CoA ratio. However, carnitine is not added to ordinary enteral nutrition or total parenteral nutrition. In this study, we determined the serum carnitine concentrations in sub...

journal_title：Journal of clinical biochemistry and nutrition

authors： Iwamoto J,Honda A,Miyamoto Y,Miyazaki T,Murakami M,Saito Y,Ikegami T,Miyamoto J,Matsuzaki Y

更新日期：2014-11-01 00:00:00

abstract：:Biomedical evidence in the last 20 years has shown that the consumption of partially hydrolyzed guar gum may influence lipid and/or carbohydrate metabolism at many levels. Since intestine represents the first interface to interact with dietary partially hydrolyzed guar gum in vivo, we evaluated gene expression profile...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yasukawa Z,Naito Y,Takagi T,Mizushima K,Tokunaga M,Ishihara N,R Juneja L,Yoshikawa T

更新日期：2012-07-01 00:00:00

abstract：:Overexpression of IGF-1R has been demonstrated in gastrointestinal cancers, and its expression is reported as the result of the loss of tumor suppressors. IL-16 is involved in the pathophysiological process of chronic inflammatory diseases. The aim of this study is to determine the changes in the expression of IGF-1R ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nakajima N,Kozu K,Kobayashi S,Nishiyama R,Okubo R,Akai Y,Moriyama M,Kinukawa N

更新日期：2016-07-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is common in patients with many chronic diseases, but has not been well recognized in rheumatoid arthritis (RA). We investigated the prevalence of GERD symptoms in 278 outpatients with RA and their association with such clinical factors as age, sex, height, weight, body mass inde...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nampei A,Shi K,Ebina K,Tomita T,Sugamoto K,Yoshikawa H,Hirao M,Hashimoto J

更新日期：2013-03-01 00:00:00

abstract：:Kangen-karyu, a prescription containing six herbs, has been shown to achieve its pharmacological effect through oxidative stress-dependent pathways in animal models. The aim of this study is to investigate the relationship between the antioxidative effect and pharmacological mechanisms of Kangen-karyu, specifically it...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hirayama A,Okamoto T,Kimura S,Nagano Y,Matsui H,Tomita T,Oowada S,Aoyagi K

更新日期：2016-05-01 00:00:00

abstract：:Nitidine chloride (NC), a natural, bioactive, phytochemical alkaloid derived from the roots of Zanthoxylum nitidum, has been reported to exhibit anti-tumor activity against various types of cancer. However, the potential therapeutic role of NC in human cervical cancer has not yet been studied. We are the first to repo...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kwon HJ,Kim LH,Ahn CH,Yang IH,Hong KO,Doo Hong S,Shin JA,Cho SD

更新日期：2019-11-01 00:00:00

abstract：:A Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic ra...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tuitoek P,Lakey J,Rajotte R,Ziari S,Tsin A,Basu T

更新日期：1995-01-01 00:00:00

abstract：:We investigated the effect of the sodium glucose cotransporter-2 inhibitor (SGLT-2i) luseogliflozin on skeletal muscle. Eight-week-old mice were fed a standard diet or the standard diet with added luseogliflozin for 8 weeks. The mice were divided into the following four genotype/dietary groups: Db/m mice without SGLT-...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamura T,Hashimoto Y,Osaka T,Fukuda T,Hamaguchi M,Fukui M

更新日期：2019-07-01 00:00:00

abstract：:This study investigated the effects of a drink supplement containing Momordica charantia extract from bitter melon on physical fitness and levels of stress hormones during a four-week exercise training program in a hot environment. Ten male tennis players were orally administrated in a four-week (100 ml, 6 times a day...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yook JS,Kwak JJ,Jeong WM,Song YH,Hijioka Y,Honda Y,Kim SE,Ha MS

更新日期：2020-11-01 00:00:00

abstract：:Nitric oxide (NO), produced by inducible NO synthase (iNOS) during infection, plays a crucial role in host defense mechanisms. Salmonella typhimurium infection in mice is associated with excessive production of NO from iNOS as a host defense response. An important cytoprotective and antimicrobial function of NO is med...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamoto T,Khan S,Oyama K,Fujii S,Sawa T,Akaike T

更新日期：2010-01-01 00:00:00

abstract：:We investigated the effects of treatment with antibodies against tumor necrosis factor (TNF)-α on energy metabolism, nutritional status, serum cytokine levels in patients with Crohn's disease (CD). Twelve patients were enrolled. Resting energy expenditure (REE) levels were measured by indirect calorimetry. Crohn's dis...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nishida N,Sasaki M,Kurihara M,Ichimaru S,Wakita M,Bamba S,Andoh A,Fujiyama Y,Amagai T

更新日期：2013-09-01 00:00:00

abstract：:Previously, we identified four metabolites of (-)-epicatechin in blood and urine: (-)-epicatechin-3'-O-glucuronide (E3'G), 4'-O-methyl-(-)-epicatechin-3'-O-glucuronide (4'ME3'G), (-)-epicatechin-7-O-glucuronide (E7G), and 3'-O-methyl-(-)-epicatechin-7-O-glucuronide (3'ME7G) (Natsume et al. Free Radical Biol. Med. 34, ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Natsume M,Osakabe N,Yasuda A,Osawa T,Terao J

更新日期：2008-01-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are now commonly used for the treatment of acid related diseases such as peptic ulcer and reflux esophagitis. Because of their ability to produce direct inhibition of the proton pump, PPIs provide more sustained increase of the gastric pH than H(2)-receptor (H(2)R) antagonists. Diverse re...

journal_title：Journal of clinical biochemistry and nutrition

authors： Masaoka T,Suzuki H,Hibi T

更新日期：2008-05-01 00:00:00

abstract：:Citrus bioflavonoids may offer some protection against the early stage of diabetes mellitus and the development of complications. We investigated the effect of hesperidin on blood glucose levels, hepatic glucose-regulating enzyme activities, serum insulin and adiponectin levels, serum and hepatic lipid levels, and par...

journal_title：Journal of clinical biochemistry and nutrition

authors： Akiyama S,Katsumata S,Suzuki K,Ishimi Y,Wu J,Uehara M

更新日期：2010-01-01 00:00:00

abstract：:Inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD). However, detailed data regarding the possible association between the genetic factors of inflammation related molecules and FD are not available. Toll like receptor 2 (TLR2) and mannan-binding lectin (...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tahara T,Shibata T,Wang F,Yamashita H,Hirata I,Arisawa T

更新日期：2010-11-01 00:00:00

abstract：:Antioxidant supplementations are commonly used as an ergogenic aid for physical exercise despite its limited evidence. The study aimed to investigate the effects of a polyphenol mixture and vitamins on exercise endurance capacity. Seventy regularly exercising male participants were randomly assigned to receive oligome...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kang SW,Hahn S,Kim JK,Yang SM,Park BJ,Chul Lee S

更新日期：2012-03-01 00:00:00

abstract：:Recently, we administered fish oil containing eicosapentaenoic acid and docosahexaenoic acid (DHA) to senescence-accelerated mice P8 (SAMP8), in order to investigate the effects on lifespan. Surprisingly, the lifespan of SAMP8 that were fed fish oil was shortened significantly, through a mechanism that likely involved...

journal_title：Journal of clinical biochemistry and nutrition

authors： Sugawara S,Honma T,Ito J,Kijima R,Tsuduki T

更新日期：2013-03-01 00:00:00

abstract：:Small dense LDL particles (sd-LDL) and body shape index (ABSI), were evaluated in 228 women, living in Naples, Italy (Progetto ATENA). Serum cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, insulin, HOMA, Apo B, hs-CPR and sd-LDL were measured. LDL particle separation was performed by Lipoprint System: se...

journal_title：Journal of clinical biochemistry and nutrition

authors： Gentile M,Iannuzzo G,Mattiello A,Rubba F,Panico S,Rubba P

更新日期：2017-09-01 00:00:00

abstract：:Changes in l-arginine metabolism, including increased arginase levels and decreased nitric oxide production, are involved in the pathophysiology of asthma. In this study, using an intranasal mite-induced NC/Nga mouse model of asthma, we examined whether administration of l-arginine ameliorated airway hyperresponsivene...

journal_title：Journal of clinical biochemistry and nutrition

authors： Zhang R,Kubo M,Murakami I,Setiawan H,Takemoto K,Inoue K,Fujikura Y,Ogino K

更新日期：2015-05-01 00:00:00