Partially hydrolyzed guar gum affects the expression of genes involved in host defense functions and cholesterol absorption in colonic mucosa of db/db male mice.

Abstract:

:Biomedical evidence in the last 20 years has shown that the consumption of partially hydrolyzed guar gum may influence lipid and/or carbohydrate metabolism at many levels. Since intestine represents the first interface to interact with dietary partially hydrolyzed guar gum in vivo, we evaluated gene expression profiles in small intestinal mucosa of db/db mice fed with partially hydrolyzed guar gum in an effort to delineate its effect on the small intestine. DNA microarray and real-time PCR analyses were performed to evaluate the gene expression profiles in mice small intestinal mucosa. Among the 28,853 transcripts represented on the GeneChip® microarray, no more than 20 genes exhibited up- or down-regulation by 1.5-fold or more after four weeks following partially hydrolyzed guar gum consumption. No adverse effects were apparent. We detected up- or down-regulation of some genes known to be involved in host defense functions and cholesterol absorption.

journal_name

J Clin Biochem Nutr

authors

Yasukawa Z,Naito Y,Takagi T,Mizushima K,Tokunaga M,Ishihara N,R Juneja L,Yoshikawa T

doi

10.3164/jcbn.11-104

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

33-8

issue

1

eissn

0912-0009

issn

1880-5086

pii

jcbn11-104

journal_volume

51

pub_type

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