Fish oil changes the lifespan of Caenorhabditis elegans via lipid peroxidation.

abstract：:This study aimed to consider the significance of breast milk in preventing oxidative stress by comparing total antioxidant capacity (TAC) in breast milk and formula milk for premature infants, demonstrating the relationship between TAC in breast milk and postnatal age in days. We used the biological anti-oxidant poten...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ezaki S,Ito T,Suzuki K,Tamura M

更新日期：2008-03-01 00:00:00

abstract：:Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatie...

journal_title：Journal of clinical biochemistry and nutrition

authors： Arisawa T,Arisawa S,Yokoi T,Kuroda M,Hirata I,Nakano H

更新日期：2007-01-01 00:00:00

abstract：:In the past few decades, many types of functional factors have been identified in dietary foods; for example, flavonoids are major groups widely distributed in the plant kingdom. However, the absorption rates of the functional food factors are usually low, and many of these are difficult to be absorbed in the intact f...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tsurusaki T,Sakakibara H,Aoshima Y,Yamazaki S,Sakono M,Shimoi K

更新日期：2013-05-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer metastasis. In this study, we evaluated the effect of heat treatment on tumor growth factor-β1 (TGF-β1)-induced EMT in pancreatic cancer cells and tried to ascertain the mechanism related to any observed effects. Human pancreatic cancer cell lines ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kimura-Tsuchiya R,Ishikawa T,Kokura S,Mizushima K,Adachi S,Okajima M,Matsuyama T,Okayama T,Sakamoto N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Yagi N,Naito Y,Itoh Y

更新日期：2014-07-01 00:00:00

abstract：:There has been considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat human diseases. They are naturally occurring substances found in plants. Ferulic acid (FA) is a phytochemical commonly found in fruits and vegetables such as tomatoes, sweet corn and rice b...

journal_title：Journal of clinical biochemistry and nutrition

authors： Srinivasan M,Sudheer AR,Menon VP

更新日期：2007-03-01 00:00:00

abstract：:Cardiovascular disease is a major cause of death among hemodialysis patients. Hyperphosphatemia induces cardiovascular disease through vascular endothelial dysfunction and calcification. Repetition of a short-term excessive-phosphorus (P) diet causes transient elevations in plasma P and subsequent vascular endothelial...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tani M,Tanaka S,Takamiya K,Sakaue M,Ito M

更新日期：2020-03-01 00:00:00

abstract：:We investigated the effects of anticancer agents on peripheral blood mononuclear cells for the purpose of providing data to support new translational chemoimmunotherapy regimens. Peripheral-blood mononuclear cells were treated with one of four anticancer agents (5-fluorouracil, irinotecan, cisplatin, and gemcitabine) ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Sakai H,Kokura S,Ishikawa T,Tsuchiya R,Okajima M,Matsuyama T,Adachi S,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Yagi N,Naito Y,Yoshikawa T

更新日期：2013-01-01 00:00:00

abstract：:The effects of inulin on the microbial composition and faecal characteristics in 36 healthy, formula-fed infants (average age 7.7 months) given 3 different daily dosages of native inulin (0.75 g/day, 1.00 g/day, and 1.25 g/day) were studied. At all levels of inulin consumption, a significant (p<0.05) reduction of pote...

journal_title：Journal of clinical biochemistry and nutrition

authors： K W Yap W,Mohamed S,Husni Jamal M,Diederick M,A Manap Y

更新日期：2008-11-01 00:00:00

abstract：:Anti-peptic and anti-inflammatory actions of ecabet sodium might be beneficial in either improving gastritis or relieving dyspeptic symptoms. This study was designed to evaluate the clinical efficacy of ecabet sodium on dyspeptic symptoms and to elucidate the molecular mechanism attributable to symptom relief in patie...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yang Kim H,Hahm KB,Choi MG,Rew JS,Seol SY,Chun HJ,Lee OY,Hong WS

更新日期：2007-11-01 00:00:00

abstract：:The relationship between Helicobacter pylori (H. pylori) eradication therapy and the risk of developing gastroesophageal reflux disease (GERD) is controversial. We investigated the influence of H. pylori eradication on the risk of GERD by focusing on the quality of life (QOL) and evaluating reflux symptoms. Patients w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hirata K,Suzuki H,Matsuzaki J,Masaoka T,Saito Y,Nishizawa T,Iwasaki E,Fukuhara S,Okada S,Hibi T

更新日期：2013-03-01 00:00:00

abstract：:The pathophysiology of hypertension or stroke is associated with an excess of ROS generation in the vascular system, and results in induction of various pathological cascades of cerebrovascular damage. We have demonstrated that electron spin resonance methods using a spin trap or spin probe will be useful for understa...

journal_title：Journal of clinical biochemistry and nutrition

authors： Lee MC

更新日期：2013-01-01 00:00:00

abstract：:Mammals have the biological clocks with approximately 24 h-rhythm. Energy metabolism including glucose metabolism is regulated by the biological clocks. Glucose metabolism is affected by not only meal volume and its energy but also meal timing. We have reported that cacao liquor procyanidin-rich extract (CLPr) amelior...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hironao KY,Ashida H,Yamashita Y

更新日期：2020-07-01 00:00:00

abstract：:Spironolactone and furosemide, which are used to treat ascites associated with decompensated cirrhosis, are ineffective in treating refractory ascites. Hence, combination therapy with tolvaptan, a vasopressin V2 receptor antagonist, has been approved in Japan. Tolvaptan monotherapy and combination therapy with furosem...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tanabe N,Takami T,Fujisawa K,Matsumoto T,Yamamoto N,Sakaida I

更新日期：2017-07-01 00:00:00

abstract：:It has been reported that levels of soluble intercellular adhesion molecule-1 (ICAM-1) in the blood are elevated in hepatocellular carcinoma patients. In the present study, serial observations of the localization of ICAM-1 in the liver were made by light and electron microscopy in rats with carcinogen-induced cancer. ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Matsuoka S,Matsumura H,Arakawa Y,Nakamura H,Nirei K,Yamagami H,Ogawa M,Nakajima N,Amaki S,Tanaka N,Moriyama M

更新日期：2009-09-01 00:00:00

abstract：:We investigated the effect of the sodium glucose cotransporter-2 inhibitor (SGLT-2i) luseogliflozin on skeletal muscle. Eight-week-old mice were fed a standard diet or the standard diet with added luseogliflozin for 8 weeks. The mice were divided into the following four genotype/dietary groups: Db/m mice without SGLT-...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamura T,Hashimoto Y,Osaka T,Fukuda T,Hamaguchi M,Fukui M

更新日期：2019-07-01 00:00:00

abstract：:The effects of topical application of Rafflesia hasseltii buds and flowers extract on the rate of wound healing and histology of healed wound were assessed. Four groups of adult male Sprague Dawley rats were experimentally wounded in the posterior neck area. A thin layer of blank placebo was applied topically to wound...

journal_title：Journal of clinical biochemistry and nutrition

authors： Abdulla MA,Ahmed KA,Ali HM,Noor SM,Ismail S

更新日期：2009-11-01 00:00:00

abstract：:Gastrointestinal symptoms are a problematic issue for patients who take low-dose aspirin for long time. We conducted a pilot study to investigate the efficacy of combination therapy with proton pump inhibitor and rebamipide. This was a prospective, randomized, double-blind, placebo-controlled cross-over study. All the...

journal_title：Journal of clinical biochemistry and nutrition

authors： Mizukami K,Murakami K,Hirashita Y,Hisamatsu A,Ogawa R,Uchida M,Nakagawa Y,Okimoto T,Kodama M,Fujioka T

更新日期：2012-11-01 00:00:00

abstract：:Carnitine is a vitamin-like compound that plays important roles in fatty acid β-oxidation and the control of the mitochondrial coenzyme A/acetyl-CoA ratio. However, carnitine is not added to ordinary enteral nutrition or total parenteral nutrition. In this study, we determined the serum carnitine concentrations in sub...

journal_title：Journal of clinical biochemistry and nutrition

authors： Iwamoto J,Honda A,Miyamoto Y,Miyazaki T,Murakami M,Saito Y,Ikegami T,Miyamoto J,Matsuzaki Y

更新日期：2014-11-01 00:00:00

abstract：:Daily salt intake can be estimated by measuring sodium and creatinine concentrations in spot urine. Excessive salt intake is risk factor for gastric cancer. We examined the correlation between estimated salt intake from spot urine and risk of gastric cancer. This study included gastric cancer patients who underwent tr...

journal_title：Journal of clinical biochemistry and nutrition

authors： Goto A,Nishikawa J,Ito S,Hideura E,Shirasawa T,Hamabe K,Hashimoto S,Okamoto T,Yanai H,Sakaida I

更新日期：2020-01-01 00:00:00

abstract：:Vitamin E analog, such as α- and γ-tocopherol, can undergo ω-oxidation without cleavage of the chroman ring, and this pathway is responsible for generation of the major urinary vitamin E metabolite, carboxyethyl hydroxychroman. However, it is still unclear how carboxyethyl hydroxychroman is changed in various tissues ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kiyose C,Saito K,Yachi R,Muto C,Igarashi O

更新日期：2015-03-01 00:00:00

abstract：:Plant sterols are used as food additives to reduce intestinal cholesterol absorption. They also increase fecal neutral sterol (FNS) excretion irrespective of the absorption inhibition. Intestine-mediated reverse cholesterol transport, or trans-intestinal cholesterol efflux (TICE), provides the major part of the increa...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nakano T,Inoue I,Takenaka Y,Ikegami Y,Kotani N,Shimada A,Noda M,Murakoshi T

更新日期：2018-09-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is common in patients with many chronic diseases, but has not been well recognized in rheumatoid arthritis (RA). We investigated the prevalence of GERD symptoms in 278 outpatients with RA and their association with such clinical factors as age, sex, height, weight, body mass inde...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nampei A,Shi K,Ebina K,Tomita T,Sugamoto K,Yoshikawa H,Hirao M,Hashimoto J

更新日期：2013-03-01 00:00:00

abstract：:Although some studies have indicated a correlation between Helicobacter pylori infection and the risk of colorectal neoplasms, these findings have not been consistent and are controversial. This case-control study aimed to investigate the association between endoscopic gastric mucosal atrophy and colorectal polyp occu...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kawahara Y,Kodama M,Mizukami K,Saito T,Hirashita Y,Sonoda A,Fukuda K,Matsunari O,Okamoto K,Ogawa R,Okimoto T,Murakami K

更新日期：2019-09-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are now commonly used for the treatment of acid related diseases such as peptic ulcer and reflux esophagitis. Because of their ability to produce direct inhibition of the proton pump, PPIs provide more sustained increase of the gastric pH than H(2)-receptor (H(2)R) antagonists. Diverse re...

journal_title：Journal of clinical biochemistry and nutrition

authors： Masaoka T,Suzuki H,Hibi T

更新日期：2008-05-01 00:00:00

abstract：:Parkinson's disease is a major neurodegenerative disease involving the selective degeneration of dopaminergic neurons and α-synuclein containing Lewy bodies formation in the substantia nigra. Although α-synuclein is a key molecule for both dopaminergic neuron death and the formation of inclusion bodies, the mechanism ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Teraoka M,Nakaso K,Kusumoto C,Katano S,Tajima N,Yamashita A,Zushi T,Ito S,Matsura T

更新日期：2012-09-01 00:00:00

abstract：:Proton pump inhibitors are the first-line treatment for reflux esophagitis. Because severe reflux esophagitis has very low prevalence in Japan, little is known about the effectiveness of proton pump inhibitors in these patients. This prospective multicenter study assessed the effectiveness of proton pump inhibitors fo...

journal_title：Journal of clinical biochemistry and nutrition

authors： Mizuno H,Matsuhashi N,Sakaguchi M,Inoue S,Nakada K,Higuchi K,Haruma K,Joh T

更新日期：2015-11-01 00:00:00

abstract：:Reactive oxygen species attack several living organs and induce cell death. Previously, we found axonal/dendrite degeneration before the induction of cell death in hydrogen peroxide-treated neuroblastoma: N1E-115 cells and primary neurons. This phenomenon may be connected with membrane oxidation, microtubule destabili...

journal_title：Journal of clinical biochemistry and nutrition

authors： Fukui K,Okihiro S,Ohfuchi Y,Hashimoto M,Kato Y,Yoshida N,Mochizuki K,Tsumoto H,Miura Y

更新日期：2019-01-01 00:00:00

abstract：:Serum alanine aminotransferase (ALT) concentration is the most commonly used marker for hepatocellular injury. We investigated the suitable cutoff value of serum ALT for the diagnosis or prediction of fatty liver. In 1578 Japanese adults (1208 men, 370 women; 35-69 years of age) who visited our center both in 2000 and...

journal_title：Journal of clinical biochemistry and nutrition

authors： Omagari K,Takamura R,Matsutake S,Ichimura M,Kato S,Morikawa S,Nagaoka S,Osabe M

更新日期：2011-11-01 00:00:00

abstract：:In this study, we examined whether compound 48/80 (C48/80), a mast cell degranulator, causes hepatic oxidative damage in rats. Serum and liver biochemical parameters were determined 0.5, 3 or 6 h after a single treatment with C48/80 (0.75 mg/kg). Serum histamine and serotonin levels increased 0.5 h after C48/80 treatm...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ohta Y,Yashiro K,Ohashi K,Horikoshi Y,Kusumoto C,Matsura T

更新日期：2017-05-01 00:00:00

abstract：:The amount of phosphorus contained in food as food additives is currently increasing and a high intake of phosphorus can cause various diseases. To determine the effects of a prolonged high phosphorus diet, here we investigated the phosphorus and calcium balance and expression of type IIa sodium-dependent phosphate tr...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tani Y,Sato T,Yamanaka-Okumura H,Yamamoto H,Arai H,Sawada N,Genjida K,Taketani Y,Takeda E

更新日期：2007-05-01 00:00:00