Role of cyclic AMP in regulation of hepatic glucose production during exercise.

Abstract:

:Cyclic AMP increases in liver during exercise, the magnitude of the increase being dependent on duration and intensity of the exercise. Within limits, the increase in cAMP is closely correlated with the rate of glycogenolysis and with the exercise intensity. It is unlikely that epinephrine is involved in determining cAMP concentration in liver during exercise. Adrenodemedullated rats show no impairment in exercise-induced liver glycogenolysis or in the increase in cAMP. When epinephrine is infused at different rates into exercising rats, liver cAMP appears to be unrelated to plasma epinephrine. The rise in plasma glucagon is likely responsible for the increase in hepatic cAMP during exercise. The increase in cAMP is apparently necessary for maintaining low levels of fructose-2,6-bisphosphate (the activator of PFK-1 and inhibitor of fructose-1,6-bisphosphate) in liver. The low fructose-2,6-bisphosphate concentration would be expected to result in an increase rate of gluconeogenesis during exercise.

journal_name

Med Sci Sports Exerc

authors

Winder WW

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

551-9

issue

6

eissn

0195-9131

issn

1530-0315

journal_volume

20

pub_type

杂志文章,评审
  • Plasma catecholamine response to acute psychological stress in humans: relation to aerobic fitness and exercise training.

    abstract::Existing cross-sectional studies on plasma catecholamine activity provide no support for the concept that a markedly high level of aerobic fitness modifies sympathoadrenal response to an acute psychological challenge in humans. In contrast, compromised sympathetic nervous system activity has been observed in individua...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:

    authors: Sothmann MS,Hart BA,Horn TS

    更新日期:1991-07-01 00:00:00

  • Resistance training during unweighting maintains muscle size and function in human calf.

    abstract:PURPOSE:A 20-d 6 degrees head-down tilt bed rest project was conducted to evaluate the effect of dynamic leg press and plantar flexion resistance training on muscle size and function in human plantar flexors (PF) throughout the prolonged bed rest. METHODS:Twelve healthy men participated in this study and were divided ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1249/01.MSS.0000058367.66796.35

    authors: Akima H,Ushiyama J,Kubo J,Tonosaki S,Itoh M,Kawakami Y,Fukuoka H,Kanehisa H,Fukunaga T

    更新日期:2003-04-01 00:00:00

  • Addition of an Alginate Hydrogel to a Carbohydrate Beverage Enhances Gastric Emptying.

    abstract:PURPOSE:This study aimed to examine the effect of altering osmolality or adding sodium alginate and pectin to a concentrated carbohydrate (CHO) beverage on gastric-emptying (GE) rate. METHODS:Boluses (500 mL) of three drinks were instilled double blind in eight healthy men while seated, GE was measured using the doubl...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000002301

    authors: Sutehall S,Galloway SDR,Bosch A,Pitsiladis Y

    更新日期:2020-08-01 00:00:00

  • Response of serum hormones to androgen administration in power athletes.

    abstract::Endocrine effects of self-administration of high doses of anabolic steroids and testosterone were investigated in five power athletes during 26 wk of training, and for the following 12-16 wk after drug withdrawal. After 26 wk of anabolic steroid and testosterone administration, serum testosterone concentrations had in...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Alén M,Reinilä M,Vihko R

    更新日期:1985-06-01 00:00:00

  • Vertical and radial motions of the body during the take-off phase of high jumping.

    abstract::By placing the muscles of the take-off leg in faster eccentric or slower concentric conditions, a high jumper can increase the ground reaction force and the height of the jump. Film analysis of seven high jumpers showed that the radial velocity of the center of mass with respect to the supporting foot was more negativ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/00005768-198806000-00014

    authors: Dapena J,Chung CS

    更新日期:1988-06-01 00:00:00

  • The effects of anabolic steroids and strength training on the human immune response.

    abstract::The immune response was assessed in 13 competitive bodybuilders self-administering anabolic-androgenic steroids and ten competitive bodybuilders not administering these drugs. Laboratory assessment included the number and relative distribution of T-cells, T-helper/inducer cells, T-cytotoxic/suppressor cells, activated...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:

    authors: Calabrese LH,Kleiner SM,Barna BP,Skibinski CI,Kirkendall DT,Lahita RG,Lombardo JA

    更新日期:1989-08-01 00:00:00

  • Effects of acute modafinil ingestion on exercise time to exhaustion.

    abstract:PURPOSE:The purpose of this study was to investigate the effect of acute ingestion of modafinil (M) on time to exhaustion during high-intensity exercise. Modafinil (M) is a psychostimulant developed to treat narcolepsy, with "arousal" properties attributed to an increased release of dopamine in the CNS. Because other s...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章

    doi:10.1249/01.mss.0000128146.12004.4f

    authors: Jacobs I,Bell DG

    更新日期:2004-06-01 00:00:00

  • Exercise restores immune cell function in energy-restricted rats.

    abstract:OBJECTIVE:To evaluate the effect of chronic moderate-intensity exercise upon the alterations of immune system cell function induced by energy restriction. METHODS:Forty male Wistar rats were randomly assigned to the following groups: sedentary animals fed ad libitum (SF, N = 10) or submitted to energy restriction (SER...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000147626.32295.38

    authors: Dos Santos Cunha WD,Giampietro MV,De Souza DF,Vaisberg M,Seelaender MC,Rosa LF

    更新日期:2004-12-01 00:00:00

  • Alteration of trabecular bone under chronic beta2 agonists treatment.

    abstract:PURPOSE:beta2 adrenergic agonists are widely used as doping agents. Their side effects on bone, especially microarchitecture, remain unknown. The purpose of this study was to evaluate the effects of chronic clenbuterol and salbutamol treatment on bones of growing rats. METHODS:Twelve-week-old Wistar female rats were d...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000177592.82507.95

    authors: Bonnet N,Brunet-Imbault B,Arlettaz A,Horcajada MN,Collomp K,Benhamou CL,Courteix D

    更新日期:2005-09-01 00:00:00

  • Influence of resistance exercise on lean body mass in aging adults: a meta-analysis.

    abstract:PURPOSE:sarcopenia plays a principal role in the pathogenesis of frailty and functional impairment that occur with aging. There are few published accounts that examine the overall benefit of resistance exercise (RE) for lean body mass (LBM) while considering a continuum of dosage schemes and/or age ranges. Therefore, t...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,meta分析,评审

    doi:10.1249/MSS.0b013e3181eb6265

    authors: Peterson MD,Sen A,Gordon PM

    更新日期:2011-02-01 00:00:00

  • Effects of different visual stimuli on postures and knee moments during sidestepping.

    abstract:PURPOSE:Evasive sidestepping during sports commonly results in noncontact anterior cruciate ligament injuries. Sidestepping in response to different simple visual stimuli has been studied previously but never investigated using quasi-game-realistic visual conditions. We compared the biomechanics of high-level and low-l...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e318290c28a

    authors: Lee MJ,Lloyd DG,Lay BS,Bourke PD,Alderson JA

    更新日期:2013-09-01 00:00:00

  • Modeling of end-tidal and arterial PCO2 gradient: comparison with experimental data.

    abstract:PURPOSE:The aim of this study was to test whether a tidally ventilated homogeneous lung model can correctly describe arterial and end-tidal gas partial pressures and thus the difference in end-tidal and arterial gas partial pressures at rest and during exercise. METHODS:The implemented mathematical modeling described ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200204000-00010

    authors: Benallal H,Denis C,Prieur F,Busso T

    更新日期:2002-04-01 00:00:00

  • Perceived exertion during prepregnancy physical activity and preeclampsia risk.

    abstract:PURPOSE:Studies have shown that absolute intensity of physical activity is associated with reduced risk of preeclampsia. This analysis was performed to examine whether relative intensity may also be related to preeclampsia risk. METHODS:Using data from a case-control study conducted from 1998 to 2002, the authors asse...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000175862.41620.41

    authors: Rudra CB,Williams MA,Lee IM,Miller RS,Sorensen TK

    更新日期:2005-11-01 00:00:00

  • Prevalence of chondral defects in athletes' knees: a systematic review.

    abstract:PURPOSE:To determine the prevalence of full-thickness focal chondral defects in the athlete's knee. METHODS:We conducted a systematic review of multiple databases, evaluating studies of the prevalence of articular cartilage defects in athletes. Because of the heterogeneity of data, a meta-analysis could not be perform...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:10.1249/MSS.0b013e3181d9eea0

    authors: Flanigan DC,Harris JD,Trinh TQ,Siston RA,Brophy RH

    更新日期:2010-10-01 00:00:00

  • Predictive validity of three ActiGraph energy expenditure equations for children.

    abstract:PURPOSE:This study evaluated the predictive validity of three previously published ActiGraph energy expenditure (EE) prediction equations developed for children and adolescents. METHODS:A total of 45 healthy children and adolescents (mean age: 13.7 +/- 2.6 yr) completed four 5-min activity trials (normal walking, bris...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000183848.25845.e0

    authors: Trost SG,Way R,Okely AD

    更新日期:2006-02-01 00:00:00

  • Dynamic and steady-state ventilatory and gas exchange responses to arm exercise.

    abstract::Previous studies have suggested that, for the same power output, arm exercise requires higher oxygen uptake (VO2), carbon dioxide output (VCO2), and ventilation (VE) than leg exercise and that response kinetics are slower. To evaluate these differences, four healthy subjects performed a total of 95 arm cranking tests....

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Casaburi R,Barstow TJ,Robinson T,Wasserman K

    更新日期:1992-12-01 00:00:00

  • Arterial distensibility and physical activity in the ARIC study.

    abstract:PURPOSE:Arterial distensibility decreases with age. This decrease may be associated with the initiation and/or progression of hypertension and atherosclerosis and may be attenuated by positive lifestyle habits, including habitual physical activity. We tested the hypothesis that self-reported sport, leisure, and work ph...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200112000-00014

    authors: Schmitz KH,Arnett DK,Bank A,Liao D,Evans GW,Evenson KR,Stevens J,Sorlie P,Folsom AR

    更新日期:2001-12-01 00:00:00

  • Exercise training increases heat shock protein in skeletal muscles of old rats.

    abstract:PURPOSE:The effects of chronic exercise training on the expression of heat shock protein (HSP) in skeletal muscle of senescent animals are unknown. Therefore, the purpose of this study was to investigate the effects of chronic exercise training on skeletal muscle HSP expression in both young and old rats. METHODS:Youn...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200105000-00008

    authors: Naito H,Powers SK,Demirel HA,Aoki J

    更新日期:2001-05-01 00:00:00

  • Effort tolerance in elderly women with different physical activity backgrounds.

    abstract::To study effort tolerance in elderly women with different physical activity backgrounds, 52 physically active (PA) and 42 sedentary control women (CO) aged 66-85 yr were assigned to perform cycle ergometer exercise to their volitional maximum. Oxygen uptake, respiratory exchange ratio (RER), heart rate, work power, an...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-199801000-00024

    authors: Kallinen M,Suominen H,Vuolteenaho O,Alen M

    更新日期:1998-01-01 00:00:00

  • Strength training effects on aerobic power and short-term endurance.

    abstract::Nine men participated in an exercise program (five days a week for 10 weeks) that was designed to strengthen the quadriceps muscles. This study was undertaken to determine if heavy resistance training results in an increase in endurance, Vo2max and whether the differences that are normally observed during bicycle and ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Hickson RC,Rosenkoetter MA,Brown MM

    更新日期:1980-01-01 00:00:00

  • Plasma creatine kinase activity and glutathione after eccentric exercise.

    abstract:PURPOSE:This study examined whether plasma total glutathione levels could explain the intersubject variability in the creatine kinase (CK) response to eccentric exercise. We hypothesized that the increase in plasma CK activity after eccentric exercise would be lower for individuals with low plasma total glutathione (<2...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.MSS.0000069553.47739.36

    authors: Lee J,Clarkson PM

    更新日期:2003-06-01 00:00:00

  • The isometric torque at which knee-extensor muscle reoxygenation stops.

    abstract:PURPOSE:We investigated the knee-extensor torque at which reoxygenation (inflow of arterial blood) during an isometric contraction stopped, whether this torque depended on maximal torque capacity (MTC), and whether there were differences among the synergists. METHODS:Isometric knee-extension torque was measured using ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/mss.0b013e31802dd3cc

    authors: de Ruiter CJ,Goudsmit JF,Van Tricht JA,de Haan A

    更新日期:2007-03-01 00:00:00

  • Kinematic Mechanisms of How Power Training Improves Healthy Old Adults' Gait Velocity.

    abstract:INTRODUCTION:Slow gait predicts many adverse clinical outcomes in old adults, but the mechanisms of how power training can minimize the age-related loss of gait velocity is unclear. We examined the effects of 10 wk of lower extremity power training and detraining on healthy old adults' lower extremity muscle power and ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001082

    authors: Beijersbergen CM,Granacher U,Gäbler M,Devita P,Hortobágyi T

    更新日期:2017-01-01 00:00:00

  • The use of nuclear magnetic resonance to evaluate muscle injury.

    abstract::Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) are new and powerful tools to study tissue biochemistry, and to provide precise anatomical visualization of soft tissue structures. This review focuses on the use of these techniques to study exercise-induced muscle injury. MRS measurements sho...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:

    authors: McCully K,Shellock FG,Bank WJ,Posner JD

    更新日期:1992-05-01 00:00:00

  • Age and temporal trends of total physical activity among Swedish women.

    abstract:PURPOSE:Few epidemiological studies have been conducted among middle-aged women on long-term total and specific physical activity (PA) trends. We studied in a cross-sectional setting the relationship of self-reported total daily PA with age and calendar time. METHODS:In a population-based cohort of 38,988 women aged 4...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000185086.19220.b3

    authors: Orsini N,Bellocco R,Bottai M,Pagano M,Wolk A

    更新日期:2006-02-01 00:00:00

  • Prevention and treatment of injuries to runners.

    abstract::1) Many otherwise healthy runners are prevented from participating fully in their chosen endurance sport because of overuse injuries. 2) The most important risk factor for incurring an overuse injury is a training error, such as excessive mileage, sudden change in training distance or intensity, too much hard interval...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/00005768-199209001-00010

    authors: O'Toole ML

    更新日期:1992-09-01 00:00:00

  • Is running style and economy affected by wearing respiratory apparatus?

    abstract::The purposes of this investigation were to compare selected gait parameters characteristic of running without respiratory apparatus on a treadmill (NOR) with those displayed while wearing a mouthpiece-breathing valve apparatus (MP) and while wearing a respiratory face mask (MASK), and to compare the running economy (R...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Siler WL

    更新日期:1993-02-01 00:00:00

  • Associations of physical activity and sedentary behavior with regional fat deposition.

    abstract:INTRODUCTION:Increased sedentary behavior predicts greater cardiovascular morbidity and mortality and does so independently of physical activity (PA). This association is only partially explained by body mass index (BMI) and overall body fat, suggesting mechanisms besides general increased adiposity. The purpose of thi...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3182a77220

    authors: Larsen BA,Allison MA,Kang E,Saad S,Laughlin GA,Araneta MR,Barrett-Connor E,Wassel CL

    更新日期:2014-03-01 00:00:00

  • Lower-limb coordination and shoulder joint mechanics in the tennis serve.

    abstract:PURPOSE:To examine the relationship between variable lower-limb coordination and shoulder joint kinetics and kinematics in the high-performance flat first serve in tennis. METHODS:Three-dimensional data describing three flat serve (FS) techniques, each executed with varying lower-limb involvement: foot-up (FU), foot-b...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/mss.0b013e31815c6d61

    authors: Reid M,Elliott B,Alderson J

    更新日期:2008-02-01 00:00:00

  • Magnetic resonance imaging of the shoulder in the primary care setting.

    abstract::MRI is an excellent noninvasive method of diagnosing difficult shoulder problems. Although usually not needed for classic primary impingement syndrome or clinically obvious rotator cuff tears, MRI may be helpful in diagnosing secondary causes of impingement or in some cases involving partial rotator cuff tears. Some s...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:10.1097/00005768-199804001-00002

    authors: Ertl JP,Kovacs G,Burger RS

    更新日期:1998-04-01 00:00:00