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Alteration of trabecular bone under chronic beta2 agonists treatment.

Abstract：

PURPOSE:beta2 adrenergic agonists are widely used as doping agents. Their side effects on bone, especially microarchitecture, remain unknown. The purpose of this study was to evaluate the effects of chronic clenbuterol and salbutamol treatment on bones of growing rats. METHODS:Twelve-week-old Wistar female rats were divided into three groups: salbutamol (4 mg.kg(-1).d(-1)), clenbuterol (2 mg.kg(-1).d(-1)), and normal saline (0.5 mL.kg(-1).d(-1)) and treated for 6 wk. Proximal tibia and lumbar spine L4 were analyzed by absorptiometry and by 3D microcomputed tomography. Bending and compression tests were used to measure their mechanical properties. RESULTS:After 6 wk, the salbutamol and clenbuterol groups had lower bone mineral density (BMD) in the tibia, proximal tibia, and vertebrae. Trabecular number and bone volume for the vertebrae were lower in animals treated with clenbuterol (Tb.N: -14.31%, P < 0.001; BV/TV: -21.07%, P < 0.001) or salbutamol (TbN: -12.7%, P < 0.001; BV/TV: -19.7%, P < 0.001) than in controls. Mechanical properties of the tibia were affected by clenbuterol with a lower ultimate force (P = 0.02) and a trend in lower energy to ultimate force (P = 0.053). In vertebrae, salbutamol and clenbuterol induced lower ultimate force. Clenbuterol significantly increased muscle mass (+58.83%, P < 0.01) and reduced fat mass (-28.75%, P < 0.01) compared with controls +17.07 and -7.34%, respectively. CONCLUSION:This study shows a negative effect of clenbuterol and salbutamol on the mechanical properties and microarchitecture of trabecular bone. In the clenbuterol group it was notable that the bone loss contrasts with the anabolic effect on muscle mass. Clearly an increase of muscle mass with enhanced bone fragility augments the risk of fractures for humans or animals treated with beta2 agonists as part of a doping regimen.

journal_name

Med Sci Sports Exerc

journal_title

Medicine and science in sports and exercise

authors

Bonnet N,Brunet-Imbault B,Arlettaz A,Horcajada MN,Collomp K,Benhamou CL,Courteix D

doi

10.1249/01.mss.0000177592.82507.95

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

1493-501

issue

eissn

0195-9131

issn

1530-0315

pii

00005768-200509000-00007

journal_volume

pub_type

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Alteration of trabecular bone under chronic beta2 agonists treatment.