Intrinsic Functional Plasticity of the Thalamocortical System in Minimally Disabled Patients with Relapsing-Remitting Multiple Sclerosis.

Abstract:

:The thalamus plays a crucial role in sensorimotor, cognitive, and attentional circuit functions. Disruptions in thalamic connectivity are believed to underlie the symptoms of multiple sclerosis (MS). Therefore, assessing thalamocortical structural connectivity (SC) and functional connectivity (FC) may provide new insights into the mechanism of intrinsic functional plasticity in a large-scale neural network. We used resting-state FC measurement and diffusion tensor imaging probabilistic tractography to study the functional and structural integrity of the thalamocortical system in patients with relapsing-remitting MS (RRMS) and matched healthy controls. In the thalamocortical connections of RRMS patients, we found lesion load-related regional FC in the right temporal pole, which reflected compensatory hyperconnectivity related to lesion-related demyelination. We also found significant correlations between increased diffusivity and slowed cognitive processing (PASAT) or the impact of fatigue (MFIS-5), as well as between connective fiber loss and disease duration. Taken together, the evidence from SC and FC analysis of the thalamocortical system suggests that minimally disabled RRMS patients exhibit a dissociated SC-FC pattern and limited regional functional plasticity to compensate for the chronic demyelination-related loss of long-distance SC. These results also provide further evidence supporting the notion that MS is a disorder of anatomical disconnection.

journal_name

Front Hum Neurosci

authors

Zhou F,Gong H,Chen Q,Wang B,Peng Y,Zhuang Y,Zee CS

doi

10.3389/fnhum.2016.00002

subject

Has Abstract

pub_date

2016-01-25 00:00:00

pages

2

issn

1662-5161

journal_volume

10

pub_type

杂志文章
  • The neural signature of the Fraser illusion: an explorative EEG study on Fraser-like displays.

    abstract::We studied neural correlates accompanying the Fraser spiral illusion. The Fraser spiral illusion consists of twisted cords superimposed on a patchwork background arranged in concentric circles, which is typically perceived as a spiral. We tested four displays: the Fraser spiral illusion and three variants derived from...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00374

    authors: Yun X,Hazenberg SJ,Jacobs RH,Qiu J,van Lier R

    更新日期:2015-07-02 00:00:00

  • Non-invasive detection of high gamma band activity during motor imagery.

    abstract::High gamma oscillations (70-150 Hz; HG) are rapidly evolving, spatially localized neurophysiological signals that are believed to be the best representative signature of engaged neural populations. The HG band has been best characterized from invasive electrophysiological approaches such as electrocorticography becaus...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00817

    authors: Smith MM,Weaver KE,Grabowski TJ,Rao RP,Darvas F

    更新日期:2014-10-16 00:00:00

  • Content-specific coordination of listeners' to speakers' EEG during communication.

    abstract::Cognitive neuroscience has recently begun to extend its focus from the isolated individual mind to two or more individuals coordinating with each other. In this study we uncover a coordination of neural activity between the ongoing electroencephalogram (EEG) of two people-a person speaking and a person listening. The ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00266

    authors: Kuhlen AK,Allefeld C,Haynes JD

    更新日期:2012-10-01 00:00:00

  • Increased Awakenings From Non-rapid Eye Movement Sleep Explain Differences in Dream Recall Frequency in Healthy Individuals.

    abstract:Background:Dreaming is a universal experience, yet there is considerable inter-individual variability in dream recall frequency (DRF). One dominant model, the "arousal-retrieval" model, posits that intra-sleep wakefulness is required for dream traces to be encoded into long-term storage, essentially proposing that a be...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00370

    authors: van Wyk M,Solms M,Lipinska G

    更新日期:2019-10-15 00:00:00

  • Informational connectivity: identifying synchronized discriminability of multi-voxel patterns across the brain.

    abstract::The fluctuations in a brain region's activation levels over a functional magnetic resonance imaging (fMRI) time-course are used in functional connectivity (FC) to identify networks with synchronous responses. It is increasingly recognized that multi-voxel activity patterns contain information that cannot be extracted ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00015

    authors: Coutanche MN,Thompson-Schill SL

    更新日期:2013-02-07 00:00:00

  • Mal-adaptation of event-related EEG responses preceding performance errors.

    abstract::Recent EEG and fMRI evidence suggests that behavioral errors are foreshadowed by systematic changes in brain activity preceding the outcome by seconds. In order to further characterize this type of error precursor activity, we investigated single-trial event-related EEG activity from 70 participants performing a modif...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00065

    authors: Eichele H,Juvodden HT,Ullsperger M,Eichele T

    更新日期:2010-08-10 00:00:00

  • The state of the art in organizational cognitive neuroscience: the therapeutic gap and possible implications for clinical practice.

    abstract::In the last decade, researchers in the social sciences have increasingly adopted neuroscientific techniques, with the consequent rise of research inspired by neuroscience in disciplines such as economics, marketing, decision sciences, and leadership. In 2007, we introduced the term organizational cognitive neuroscienc...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00808

    authors: Senior C,Lee N

    更新日期:2013-12-05 00:00:00

  • An Increase in Postural Load Facilitates an Anterior Shift of Processing Resources to Frontal Executive Function in a Postural-Suprapostural Task.

    abstract::Increase in postural-demand resources does not necessarily degrade a concurrent motor task, according to the adaptive resource-sharing hypothesis of postural-suprapostural dual-tasking. This study investigated how brain networks are organized to optimize a suprapostural motor task when the postural load increases and ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00420

    authors: Huang CY,Chang GC,Tsai YY,Hwang IS

    更新日期:2016-08-19 00:00:00

  • Sleep Does Not Promote Solving Classical Insight Problems and Magic Tricks.

    abstract::During creative problem solving, initial solution attempts often fail because of self-imposed constraints that prevent us from thinking out of the box. In order to solve a problem successfully, the problem representation has to be restructured by combining elements of available knowledge in novel and creative ways. It...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00072

    authors: Schönauer M,Brodt S,Pöhlchen D,Breßmer A,Danek AH,Gais S

    更新日期:2018-02-26 00:00:00

  • Comparison of the Working Memory Load in N-Back and Working Memory Span Tasks by Means of EEG Frequency Band Power and P300 Amplitude.

    abstract::According to theoretical accounts, both, N-back and complex span tasks mainly require working memory (WM) processing. In contrast, simple span tasks conceptually mainly require WM storage. Thus, conceptually, an N-back task and a complex span task share more commonalities as compared to a simple span task. In the curr...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00006

    authors: Scharinger C,Soutschek A,Schubert T,Gerjets P

    更新日期:2017-01-25 00:00:00

  • Using time-to-contact information to assess potential collision modulates both visual and temporal prediction networks.

    abstract::Accurate estimates of the time-to-contact (TTC) of approaching objects are crucial for survival. We used an ecologically valid driving simulation to compare and contrast the neural substrates of egocentric (head-on approach) and allocentric (lateral approach) TTC tasks in a fully factorial, event-related fMRI design. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.010.2008

    authors: Coull JT,Vidal F,Goulon C,Nazarian B,Craig C

    更新日期:2008-09-13 00:00:00

  • A Cultural Evolution Approach to Digital Media.

    abstract::Digital media have today an enormous diffusion, and their influence on the behavior of a vast part of the human population can hardly be underestimated. In this review I propose that cultural evolution theory, including both a sophisticated view of human behavior and a methodological attitude to modeling and quantitat...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2016.00636

    authors: Acerbi A

    更新日期:2016-12-15 00:00:00

  • Devaluation and sequential decisions: linking goal-directed and model-based behavior.

    abstract::In experimental psychology different experiments have been developed to assess goal-directed as compared to habitual control over instrumental decisions. Similar to animal studies selective devaluation procedures have been used. More recently sequential decision-making tasks have been designed to assess the degree of ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00587

    authors: Friedel E,Koch SP,Wendt J,Heinz A,Deserno L,Schlagenhauf F

    更新日期:2014-08-04 00:00:00

  • Different Resting State EEG Features in Children from Switzerland and Saudi Arabia.

    abstract::Background: Cultural neuroscience is an emerging research field concerned with studying the influences of different cultures on brain anatomy and function. In this study, we examined whether different cultural or genetic influences might influence the resting state electroencephalogram (EEG) in young children (mean ag...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00559

    authors: Alahmadi N,Evdokimov SA,Kropotov YJ,Müller AM,Jäncke L

    更新日期:2016-11-02 00:00:00

  • Differential age-related changes in N170 responses to upright faces, inverted faces, and eyes in Japanese children.

    abstract::The main objectives of this study were to investigate the development of face perception in Japanese children, focusing on the changes in face processing strategies (holistic and/or configural vs. feature-based) that occur during childhood. To achieve this, we analyzed the face-related N170 component, evoked by uprigh...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00263

    authors: Miki K,Honda Y,Takeshima Y,Watanabe S,Kakigi R

    更新日期:2015-06-02 00:00:00

  • Retinotopic patterns of background connectivity between V1 and fronto-parietal cortex are modulated by task demands.

    abstract::Attention facilitates the processing of task-relevant visual information and suppresses interference from task-irrelevant information. Modulations of neural activity in visual cortex depend on attention, and likely result from signals originating in fronto-parietal and cingulo-opercular regions of cortex. Here, we tes...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00338

    authors: Griffis JC,Elkhetali AS,Burge WK,Chen RH,Visscher KM

    更新日期:2015-06-08 00:00:00

  • People of Lower Social Status Are More Sensitive to Hedonic Product Information-Electrophysiological Evidence From an ERP Study.

    abstract::Consumer psychology research has shown that individuals of different social statuses have distinctive purchase intentions for different products. Individuals of a high social status will simultaneously measure the symbolic status meaning and utilitarian value of a product, but they will not show strong preferences for...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00147

    authors: Chen D,Qu W,Xiang Y,Zhao J,Shen G

    更新日期:2019-05-15 00:00:00

  • Bi-Dimensional Approach Based on Transfer Learning for Alcoholism Pre-disposition Classification via EEG Signals.

    abstract::Recent statistics have shown that the main difficulty in detecting alcoholism is the unreliability of the information presented by patients with alcoholism; this factor confusing the early diagnosis and it can reduce the effectiveness of treatment. However, electroencephalogram (EEG) exams can provide more reliable da...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00365

    authors: Zhang H,Silva FHS,Ohata EF,Medeiros AG,Rebouças Filho PP

    更新日期:2020-09-18 00:00:00

  • EEG-informed fMRI analysis during a hand grip task: estimating the relationship between EEG rhythms and the BOLD signal.

    abstract::In the last decade, an increasing interest has arisen in investigating the relationship between the electrophysiological and hemodynamic measurements of brain activity, such as EEG and (BOLD) fMRI. In particular, changes in BOLD have been shown to be associated with changes in the spectral profile of neural activity, ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00186

    authors: Sclocco R,Tana MG,Visani E,Gilioli I,Panzica F,Franceschetti S,Cerutti S,Bianchi AM

    更新日期:2014-04-01 00:00:00

  • Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey.

    abstract::The lateral habenula (LHb) plays an important role in motivational decision making. Neurons in the primate LHb signal negative 'reward prediction errors' and inhibit midbrain dopamine (DA) neurons. These negative reward prediction error signals in the LHb are, at least partly, provided by a distinct group of neurons i...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00778

    authors: Hong S,Hikosaka O

    更新日期:2013-11-13 00:00:00

  • A Multi-Target Motor Imagery Training Using Bimodal EEG-fMRI Neurofeedback: A Pilot Study in Chronic Stroke Patients.

    abstract::Traditional rehabilitation techniques present limitations and the majority of patients show poor 1-year post-stroke recovery. Thus, Neurofeedback (NF) or Brain-Computer-Interface applications for stroke rehabilitation purposes are gaining increased attention. Indeed, NF has the potential to enhance volitional control ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00037

    authors: Lioi G,Butet S,Fleury M,Bannier E,Lécuyer A,Bonan I,Barillot C

    更新日期:2020-02-18 00:00:00

  • Cortical responses to salient nociceptive and not nociceptive stimuli in vegetative and minimal conscious state.

    abstract:AIMS:Questions regarding perception of pain in non-communicating patients and the management of pain continue to raise controversy both at a clinical and ethical level. The aim of this study was to examine the cortical response to salient visual, acoustic, somatosensory electric non-nociceptive and nociceptive laser st...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00017

    authors: de Tommaso M,Navarro J,Lanzillotti C,Ricci K,Buonocunto F,Livrea P,Lancioni GE

    更新日期:2015-01-29 00:00:00

  • Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation.

    abstract::This review focuses on the cognitive neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) based on functional magnetic resonance imaging (fMRI) studies and on recent clinically relevant applications such as fMRI-based diagnostic classification or neuromodulation therapies targeting fMRI deficits with neurof...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2018.00100

    authors: Rubia K

    更新日期:2018-03-29 00:00:00

  • Voluntary Out-of-Body Experience: An fMRI Study.

    abstract::The present single-case study examined functional brain imaging patterns in a participant that reported being able, at will, to produce somatosensory sensations that are experienced as her body moving outside the boundaries of her physical body all the while remaining aware of her unmoving physical body. We found that...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00070

    authors: Smith AM,Messier C

    更新日期:2014-02-10 00:00:00

  • Performance improvements from imagery: evidence that internal visual imagery is superior to external visual imagery for slalom performance.

    abstract::We report three experiments investigating the hypothesis that use of internal visual imagery (IVI) would be superior to external visual imagery (EVI) for the performance of different slalom-based motor tasks. In Experiment 1, three groups of participants (IVI, EVI, and a control group) performed a driving-simulation s...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00697

    authors: Callow N,Roberts R,Hardy L,Jiang D,Edwards MG

    更新日期:2013-10-21 00:00:00

  • Corrigendum "fNIRS-based brain-computer interfaces: a review".

    abstract::[This corrects the article on p. 3 in vol. 9, PMID: 25674060.]. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnhum.2015.00172

    authors: Naseer N,Hong KS

    更新日期:2015-03-26 00:00:00

  • Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals' perspective taking ability and autistic-like traits.

    abstract::Previous studies have indicated that empathic traits, such as perspective taking, are associated with the levels of serotonin in the brain and with autism spectrum conditions. Inspired by the finding that the serotonin receptor 2A gene (HTR2A) modulates the availability of serotonin, this study investigated to what ex...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00575

    authors: Gong P,Liu J,Blue PR,Li S,Zhou X

    更新日期:2015-10-23 00:00:00

  • The world according to me: personal relevance and the medial prefrontal cortex.

    abstract::More than a decade of neuroimaging research has established that anterior and posterior cortical midline regions are consistently recruited during self-referential thinking. These regions are engaged under conditions of directed cognition, such as during explicit self-reference tasks, as well as during spontaneous cog...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00341

    authors: Abraham A

    更新日期:2013-07-02 00:00:00

  • Spatial task context makes short-latency reaches prone to induced Roelofs illusion.

    abstract::The perceptual localization of an object is often more prone to illusions than an immediate visuomotor action towards that object. The induced Roelofs effect (IRE) probes the illusory influence of task-irrelevant visual contextual stimuli on the processing of task-relevant visuospatial instructions during movement pre...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00673

    authors: Taghizadeh B,Gail A

    更新日期:2014-08-29 00:00:00

  • A cognitive training intervention increases resting cerebral blood flow in healthy older adults.

    abstract::Healthy aging is typically accompanied by some decline in cognitive performance, as well as by alterations in brain structure and function. Here we report the results of a randomized, controlled trial designed to determine the effects of a novel cognitive training program on resting cerebral blood flow (CBF) and gray ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.016.2010

    authors: Mozolic JL,Hayasaka S,Laurienti PJ

    更新日期:2010-03-12 00:00:00