Abstract:
:Healthy aging is typically accompanied by some decline in cognitive performance, as well as by alterations in brain structure and function. Here we report the results of a randomized, controlled trial designed to determine the effects of a novel cognitive training program on resting cerebral blood flow (CBF) and gray matter (GM) volume in healthy older adults. Sixty-six healthy older adults participated in 8 weeks of either a training program targeting attention and distractibility or an educational control program. This training program produced significantly larger increases in resting CBF to the prefrontal cortex than the control program. Increases in blood flow were associated with reduced susceptibility to distraction after training, but not with alterations in GM volume. These data demonstrate that cognitive training can improve resting CBF in healthy older adults and that cerebral perfusion rates may be a more sensitive indicator of the benefits of cognitive training than volumetric analyses.
journal_name
Front Hum Neuroscijournal_title
Frontiers in human neuroscienceauthors
Mozolic JL,Hayasaka S,Laurienti PJdoi
10.3389/neuro.09.016.2010subject
Has Abstractpub_date
2010-03-12 00:00:00pages
16issn
1662-5161journal_volume
4pub_type
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