Fronto-Temporal Circuits in Musical Hallucinations: A PET-MR Case Study.

Abstract:

:The aim of the study is to investigate morphofunctional circuits underlying musical hallucinations (MH) in a 72-years old female that underwent a simultaneous 18fluoredeoxyglucose positron emission tomography (PET) and advanced magnetic resonance (MR) exam. This represents a particular case of MH occurred in an healthy subject, not displaying neurological or psychopathological disorders, and studied simultaneously with a multimodal approach. For the resting-state fMRI analysis a seed to seed approach was chosen. For the task-based fMRI, 4 different auditory stimuli were presented. Imaging findings were compared with data obtained by ten healthy controls matched for age and sex. Neuropsychological evaluation and questionnaires investigating depression and anxiety were also administered. PET findings showed hypermetabolism of: superior temporal gyri, anterior cingulate, left orbital frontal, and medial temporal cortices. Structural MRI did not show macroscopical lesions except for gliotic spots along the uncinate fascicle pathways with an increased cortical thickness for the right orbitofrontal cortex (p = 0.003). DTI showed increased fractional anisotropy values in the left uncinate fascicle, when compared to controls (p = 0.04). Resting-state fMRI showed increased functional connectivity between the left inferior frontal gyrus and the left temporal fusiform cortex (p = 0.01). Task-based fMRI confirmed PET findings showing an increased activation of the superior temporal gyrus in all the auditory tasks except for the monotone stimulus, with a significant activation of the left orbital frontal cortex only during the song in foreign language, object of MH. Results on cognitive test did not show cognitive impairment, excepting for the performance on Frontal Assessment Battery where the patient fails in the cognitive domains of conceptualization, sensitive to interference, and inhibitory control. The subject did not show depressive or anxiety symptoms. Summarizing, multimodal imaging analyses in the MH case showed a microstructural alteration of the left uncinate fascicle paralleled by an increased metabolism and functional connectivity of cortical regions that receive left uncinate projections (orbital frontal cortex, and medial temporal cortex). This alteration of fronto-hyppocampal circuits could be responsible of retrieval of known songs even in the absence of real stimuli.

journal_name

Front Hum Neurosci

authors

Cavaliere C,Longarzo M,Orsini M,Aiello M,Grossi D

doi

10.3389/fnhum.2018.00385

subject

Has Abstract

pub_date

2018-09-27 00:00:00

pages

385

issn

1662-5161

journal_volume

12

pub_type

杂志文章
  • Geometrical illusions are not always where you think they are: a review of some classical and less classical illusions, and ways to describe them.

    abstract::Geometrical illusions are known through a small core of classical illusions that were discovered in the second half of the nineteenth century. Most experimental studies and most theoretical discussions revolve around this core of illusions, as though all other illusions were obvious variants of these. Yet, many illusi...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2014.00856

    authors: Ninio J

    更新日期:2014-10-28 00:00:00

  • Secular Slowing of Auditory Simple Reaction Time in Sweden (1959-1985).

    abstract::There are indications that simple reaction time might have slowed in Western populations, based on both cohort- and multi-study comparisons. A possible limitation of the latter method in particular is measurement error stemming from methods variance, which results from the fact that instruments and experimental condit...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00407

    authors: Madison G,Woodley Of Menie MA,Sänger J

    更新日期:2016-08-18 00:00:00

  • Neuronal correlates of voluntary facial movements.

    abstract::Whereas the somatotopy of finger movements has been extensively studied with neuroimaging, the neural foundations of facial movements remain elusive. Therefore, we systematically studied the neuronal correlates of voluntary facial movements using the Facial Action Coding System (FACS, Ekman et al., 2002). The facial m...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00598

    authors: Krippl M,Karim AA,Brechmann A

    更新日期:2015-10-28 00:00:00

  • Automatic processing of unattended lexical information in visual oddball presentation: neurophysiological evidence.

    abstract::Previous electrophysiological studies of automatic language processing revealed early (100-200 ms) reflections of access to lexical characteristics of speech signal using the so-called mismatch negativity (MMN), a negative ERP deflection elicited by infrequent irregularities in unattended repetitive auditory stimulati...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00421

    authors: Shtyrov Y,Goryainova G,Tugin S,Ossadtchi A,Shestakova A

    更新日期:2013-08-09 00:00:00

  • Empathy, motivation, and P300 BCI performance.

    abstract::Motivation moderately influences brain-computer interface (BCI) performance in healthy subjects when monetary reward is used to manipulate extrinsic motivation. However, the motivation of severely paralyzed patients, who are potentially in need for BCI, could mainly be internal and thus, an intrinsic motivator may be ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00642

    authors: Kleih SC,Kübler A

    更新日期:2013-10-17 00:00:00

  • Are treatment effects of neurofeedback training in children with ADHD related to the successful regulation of brain activity? A review on the learning of regulation of brain activity and a contribution to the discussion on specificity.

    abstract::While issues of efficacy and specificity are crucial for the future of neurofeedback training, there may be alternative designs and control analyses to circumvent the methodological and ethical problems associated with double-blind placebo studies. Surprisingly, most NF studies do not report the most immediate result ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2015.00135

    authors: Zuberer A,Brandeis D,Drechsler R

    更新日期:2015-03-27 00:00:00

  • Individual differences in distraction by motion predicted by neural activity in MT/V5.

    abstract::Individuals differ substantially in their susceptibility to distraction by irrelevant visual information. Previous research has uncovered how individual variability in the goal-driven component of attentional control influences distraction, yet it remains unknown whether other sources of variability between individual...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00012

    authors: Lechak JR,Leber AB

    更新日期:2012-02-15 00:00:00

  • Feedback-Related Negativity and Frontal Midline Theta Reflect Dissociable Processing of Reinforcement.

    abstract::Prediction errors (PEs) encode representations of rewarding and aversive experiences and are critical to reinforcement processing. The feedback-related negativity (FRN), a component of the event-related potential (ERP) that is sensitive to valenced feedback, is believed to reflect PE signals. Reinforcement is also stu...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00452

    authors: Rawls E,Miskovic V,Moody SN,Lee Y,Shirtcliff EA,Lamm C

    更新日期:2020-01-09 00:00:00

  • Effector-Specific Characterization of Brain Dynamics in Manual vs. Oculomotor Go/NoGo Tasks.

    abstract::Motor inhibitory control (IC), the ability to suppress unwanted actions, has been previously shown to rely on domain-general IC processes that are involved in a wide range of IC tasks. Nevertheless, the existence of effector-specific regions and activation patterns that would differentiate manual vs. oculomotor respon...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.600667

    authors: Simonet M,Ruggeri P,Barral J

    更新日期:2020-12-03 00:00:00

  • Binding in working memory and frontal lobe in normal aging: is there any similarity with autism?

    abstract::Some studies highlight similarities between Autism Spectrum Disorder (ASD) and healthy aging. Indeed, the decline in older individuals' ability to create a unified representation of the individual features of an event is thought to arise from a disruption of binding within the episodic buffer of working memory (WM) as...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00090

    authors: Lecouvey G,Quinette P,Kalpouzos G,Guillery-Girard B,Bejanin A,Gonneaud J,Abbas A,Viader F,Eustache F,Desgranges B

    更新日期:2015-03-05 00:00:00

  • The Bay Area Verbal Learning Test (BAVLT): Normative Data and the Effects of Repeated Testing, Simulated Malingering, and Traumatic Brain Injury.

    abstract::Verbal learning tests (VLTs) are widely used to evaluate memory deficits in neuropsychiatric and developmental disorders. However, their validity has been called into question by studies showing significant differences in VLT scores obtained by different examiners. Here we describe the computerized Bay Area Verbal Lea...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00654

    authors: Woods DL,Wyma JM,Herron TJ,Yund EW

    更新日期:2017-01-12 00:00:00

  • Balance Impairments after Brachial Plexus Injury as Assessed through Clinical and Posturographic Evaluation.

    abstract:OBJECTIVE:To investigate whether a sensorimotor deficit of the upper limb following a brachial plexus injury (BPI) affects the upright balance. DESIGN:Eleven patients with a unilateral BPI and 11 healthy subjects were recruited. The balance assessment included the Berg Balance Scale (BBS), the number of feet touches o...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00715

    authors: Souza L,Lemos T,Silva DC,de Oliveira JM,Guedes Corrêa JF,Tavares PL,Oliveira LA,Rodrigues EC,Vargas CD

    更新日期:2016-01-25 00:00:00

  • Ketamine: 50 Years of Modulating the Mind.

    abstract::Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically fascinating. With considerably diverse molecular targets and neurophysiological properties, ketamine's effects on the central nervous system remain incompletely understood. Investigators have lever...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2016.00612

    authors: Li L,Vlisides PE

    更新日期:2016-11-29 00:00:00

  • Enhancing performance in numerical magnitude processing and mental arithmetic using transcranial Direct Current Stimulation (tDCS).

    abstract::The ability to accurately process numerical magnitudes and solve mental arithmetic is of highest importance for schooling and professional career. Although impairments in these domains in disorders such as developmental dyscalculia (DD) are highly detrimental, remediation is still sparse. In recent years, transcranial...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00244

    authors: Hauser TU,Rotzer S,Grabner RH,Mérillat S,Jäncke L

    更新日期:2013-06-06 00:00:00

  • Alterations in multidimensional motor unit number index of hand muscles after incomplete cervical spinal cord injury.

    abstract::The objective of this study was to apply a novel multidimensional motor unit number index (MD-MUNIX) technique to examine hand muscles in patients with incomplete cervical spinal cord injury (SCI). The MD-MUNIX was estimated from the compound muscle action potential (CMAP) and different levels of surface interference ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00238

    authors: Li L,Li X,Liu J,Zhou P

    更新日期:2015-05-08 00:00:00

  • The effects of breakfast on behavior and academic performance in children and adolescents.

    abstract::Breakfast consumption is associated with positive outcomes for diet quality, micronutrient intake, weight status and lifestyle factors. Breakfast has been suggested to positively affect learning in children in terms of behavior, cognitive, and school performance. However, these assertions are largely based on evidence...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00425

    authors: Adolphus K,Lawton CL,Dye L

    更新日期:2013-08-08 00:00:00

  • Feasibility and Safety of Bilateral Hybrid EEG/EOG Brain/Neural-Machine Interaction.

    abstract::Cervical spinal cord injuries (SCIs) often lead to loss of motor function in both hands and legs, limiting autonomy and quality of life. While it was shown that unilateral hand function can be restored after SCI using a hybrid electroencephalography/electrooculography (EEG/EOG) brain/neural hand exoskeleton (B/NHE), i...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.580105

    authors: Nann M,Peekhaus N,Angerhöfer C,Soekadar SR

    更新日期:2020-12-09 00:00:00

  • Implicit and Explicit Routes to Recognize the Own Body: Evidence from Brain Damaged Patients.

    abstract::Much research suggested that recognizing our own body-parts and attributing a body-part to our physical self-likely involve distinct processes. Accordingly, facilitation for self-body-parts was found when an implicit, but not an explicit, self-recognition was required. Here, we assess whether implicit and explicit bod...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00405

    authors: Candini M,Farinelli M,Ferri F,Avanzi S,Cevolani D,Gallese V,Northoff G,Frassinetti F

    更新日期:2016-08-31 00:00:00

  • Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding.

    abstract::Previous functional MRI (fMRI) studies have shown that fragile X mental retardation 1 (FMR1) fragile X premutation allele carriers (FXPCs) exhibit decreased hippocampal activation during a recall task and lower inferior frontal activation during a working memory task compared to matched controls. The molecular charact...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00297

    authors: Wang JM,Koldewyn K,Hashimoto R,Schneider A,Le L,Tassone F,Cheung K,Hagerman P,Hessl D,Rivera SM

    更新日期:2012-10-30 00:00:00

  • Dopaminergic Control of Attentional Flexibility: Inhibition of Return is Associated with the Dopamine Transporter Gene (DAT1).

    abstract::Genetic variability related to the dopamine (DA) transporter gene (DAT1) has received increasing attention as a possible modulator of human cognition. The 9-repeat allele of the DAT1 gene is presumably associated with higher striatal DA levels than the 10-repeat allele, which might support inhibitory control functions...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00053

    authors: Colzato LS,Pratt J,Hommel B

    更新日期:2010-07-13 00:00:00

  • Cognitive Function Impairments Linked to Alcohol and Cannabis Use During Adolescence: A Study of Gender Differences.

    abstract::Major neurocognitive changes occur during adolescence, making this phase one of the most critical developmental periods of life. Furthermore, this phase in life is also the time in which youth substance use begins. Several studies have demonstrated the differential associations of alcohol and cannabis use concerning t...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00095

    authors: Noorbakhsh S,Afzali MH,Boers E,Conrod PJ

    更新日期:2020-04-07 00:00:00

  • Aberrant intrinsic connectivity of hippocampus and amygdala overlap in the fronto-insular and dorsomedial-prefrontal cortex in major depressive disorder.

    abstract::Neuroimaging studies of major depressive disorder (MDD) have consistently observed functional and structural changes of the hippocampus (HP) and amygdale (AY). Thus, these brain regions appear to be critical elements of the pathophysiology of MDD. The HP and AY directly interact and show broad and overlapping intrinsi...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00639

    authors: Tahmasian M,Knight DC,Manoliu A,Schwerthöffer D,Scherr M,Meng C,Shao J,Peters H,Doll A,Khazaie H,Drzezga A,Bäuml J,Zimmer C,Förstl H,Wohlschläger AM,Riedl V,Sorg C

    更新日期:2013-10-01 00:00:00

  • More Than Words: Extra-Sylvian Neuroanatomic Networks Support Indirect Speech Act Comprehension and Discourse in Behavioral Variant Frontotemporal Dementia.

    abstract::Indirect speech acts-responding "I forgot to wear my watch today" to someone who asked for the time-are ubiquitous in daily conversation, but are understudied in current neurobiological models of language. To comprehend an indirect speech act like this one, listeners must not only decode the lexical-semantic content o...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.598131

    authors: Healey M,Howard E,Ungrady M,Olm CA,Nevler N,Irwin DJ,Grossman M

    更新日期:2021-01-14 00:00:00

  • Recipient design in human communication: simple heuristics or perspective taking?

    abstract::Humans have a remarkable capacity for tuning their communicative behaviors to different addressees, a phenomenon also known as recipient design. It remains unclear how this tuning of communicative behavior is implemented during live human interactions. Classical theories of communication postulate that recipient desig...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00253

    authors: Blokpoel M,van Kesteren M,Stolk A,Haselager P,Toni I,van Rooij I

    更新日期:2012-09-25 00:00:00

  • Drift and ownership toward a distant virtual body.

    abstract::In body ownership illusions participants feel that a mannequin or virtual body (VB) is their own. Earlier results suggest that body ownership over a body seen from behind in extra personal space is possible when the surrogate body is visually stroked and tapped on its back, while spatially and temporal synchronous tac...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00908

    authors: Pomés A,Slater M

    更新日期:2013-12-25 00:00:00

  • Real World Problem-Solving.

    abstract::Real world problem-solving (RWPS) is what we do every day. It requires flexibility, resilience, resourcefulness, and a certain degree of creativity. A crucial feature of RWPS is that it involves continuous interaction with the environment during the problem-solving process. In this process, the environment can be seen...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00261

    authors: Sarathy V

    更新日期:2018-06-26 00:00:00

  • Enhancing emotional experiences to dance through music: the role of valence and arousal in the cross-modal bias.

    abstract::It is well established that emotional responses to stimuli presented to one perceptive modality (e.g., visual) are modulated by the concurrent presentation of affective information to another modality (e.g., auditory)-an effect known as the cross-modal bias. However, the affective mechanisms mediating this effect are ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00757

    authors: Christensen JF,Gaigg SB,Gomila A,Oke P,Calvo-Merino B

    更新日期:2014-10-06 00:00:00

  • The Brain from Within.

    abstract::Functional magnetic resonance imaging (fMRI) provides a powerful way to visualize brain functions and observe brain activity in response to tasks or thoughts. It allows displaying brain damages that can be quantified and linked to neurobehavioral deficits. fMRI can potentially draw a new cartography of brain functiona...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2016.00265

    authors: di Porzio U

    更新日期:2016-06-08 00:00:00

  • Working-memory training in younger and older adults: training gains, transfer, and maintenance.

    abstract::Working memory (WM), a key determinant of many higher-order cognitive functions, declines in old age. Current research attempts to develop process-specific WM training procedures, which may lead to general cognitive improvement. Adaptivity of the training as well as the comparison of training gains to performance chan...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00063

    authors: Brehmer Y,Westerberg H,Bäckman L

    更新日期:2012-03-27 00:00:00

  • Disentangling the attention network test: behavioral, event related potentials, and neural source analyses.

    abstract:BACKGROUND:The study of the attentional system remains a challenge for current neuroscience. The "Attention Network Test" (ANT) was designed to study simultaneously three different attentional networks (alerting, orienting, and executive) based in subtraction of different experimental conditions. However, some studies ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00813

    authors: Galvao-Carmona A,González-Rosa JJ,Hidalgo-Muñoz AR,Páramo D,Benítez ML,Izquierdo G,Vázquez-Marrufo M

    更新日期:2014-10-13 00:00:00