FMRI in translation: the challenges facing real-world applications.

Abstract:

:Functional neuroimaging has increased our understanding of human brain function tremendously and has become a standard tool in clinical and cognitive neuroscience research. We briefly review its methodological foundations and describe remaining challenges for translational research. The application of neuroimaging results to individual subjects, for example in predicting treatment response or determining the veracity of a statement, is limited by these challenges, in particular by the anatomical and statistical procedures commonly employed. We thus argue for sincere caution in the translation of functional neuroimaging to real-world applications.

journal_name

Front Hum Neurosci

authors

Schleim S,Roiser JP

doi

10.3389/neuro.09.063.2009

subject

Has Abstract

pub_date

2009-12-23 00:00:00

pages

63

issn

1662-5161

journal_volume

3

pub_type

杂志文章
  • Fairness overrides reputation: the importance of fairness considerations in altruistic cooperation.

    abstract::Behavioral findings in several strategic games indicate that people punish others if they think they are being treated unequally, even at the cost of minimizing their own material payoff. We investigated the primary driving force behind such non-self-regarding behavior, so-called, altruistic cooperation. In all of our...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00252

    authors: Güney S,Newell BR

    更新日期:2013-06-07 00:00:00

  • Estimation of Human Workload from the Auditory Steady-State Response Recorded via a Wearable Electroencephalography System during Walking.

    abstract::Workload in the human brain can be a useful marker of internal brain state. However, due to technical limitations, previous workload studies have been unable to record brain activity via conventional electroencephalography (EEG) and magnetoencephalography (MEG) devices in mobile participants. In this study, we used a ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00314

    authors: Yokota Y,Tanaka S,Miyamoto A,Naruse Y

    更新日期:2017-06-13 00:00:00

  • Decoding covert shifts of attention induced by ambiguous visuospatial cues.

    abstract::Simple and unambiguous visual cues (e.g., an arrow) can be used to trigger covert shifts of visual attention away from the center of gaze. The processing of visual stimuli is enhanced at the attended location. Covert shifts of attention modulate the power of cerebral oscillations in the alpha band over parietal and oc...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00358

    authors: Trachel RE,Clerc M,Brochier TG

    更新日期:2015-06-18 00:00:00

  • Enhanced Functional Connectivity between the Bilateral Primary Motor Cortices after Acupuncture at Yanglingquan (GB34) in Right-Hemispheric Subcortical Stroke Patients: A Resting-State fMRI Study.

    abstract::Increasing neuroimaging researches in stroke rehabilitation had revealed the neural mechanisms of rehabilitation therapy. However, little was known about the neural mechanisms of acupuncture therapy in subcortical stroke patients. The aim of this study was to investigate the changes of functional connectivity (FC) bet...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00178

    authors: Ning Y,Li K,Fu C,Ren Y,Zhang Y,Liu H,Cui F,Zou Y

    更新日期:2017-04-10 00:00:00

  • Discrete sequence production with and without a pause: the role of cortex, basal ganglia, and cerebellum.

    abstract::Our sensorimotor experience unfolds in sequences over time. We hypothesize that the processing of movement sequences with and without a temporal pause will recruit distinct but cooperating neural processes, including cortico-striatal and cortico-cerebellar networks. We thus, compare neural activity during sequence lea...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00492

    authors: Jouen AL,Verwey WB,van der Helden J,Scheiber C,Neveu R,Dominey PF,Ventre-Dominey J

    更新日期:2013-09-18 00:00:00

  • Modeling Uncertainties in EEG Microstates: Analysis of Real and Imagined Motor Movements Using Probabilistic Clustering-Driven Training of Probabilistic Neural Networks.

    abstract::Part of the process of EEG microstate estimation involves clustering EEG channel data at the global field power (GFP) maxima, very commonly using a modified K-means approach. Clustering has also been done deterministically, despite there being uncertainties in multiple stages of the microstate analysis, including the ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00534

    authors: Dinov M,Leech R

    更新日期:2017-11-01 00:00:00

  • Calibrating Doppler imaging of preterm intracerebral circulation using a microvessel flow phantom.

    abstract:INTRODUCTION:Preterm infants are born during critical stages of brain development, in which the adaptive capacity of the fetus to extra-uterine environment is limited. Inadequate brain perfusion has been directly linked to preterm brain damage. Advanced high-frequency ultrasound probes and processing algorithms allow v...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.01068

    authors: Camfferman FA,Ecury-Goossen GM,La Roche JE,de Jong N,van 't Leven W,Vos HJ,Verweij MD,Nasserinejad K,Cools F,Govaert P,Dudink J

    更新日期:2015-01-13 00:00:00

  • Empathy-Related Brain Activity in Somatosensory Cortex Protects From Tactile Priming Effects: A Pilot Study.

    abstract::Empathy influences how we perceive, understand, and interact with our social environment. Previous studies suggested a network of different brain regions as a neural substrate for empathy, including, in particular, insula and anterior cingulate cortex (ACC). In addition, a contribution of the somatosensory cortices fo...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00142

    authors: Schaefer M,Cherkasskiy L,Denke C,Spies C,Song H,Malahy S,Heinz A,Ströhle A,Schäfer M,Mianroudi N,Bargh JA

    更新日期:2020-05-21 00:00:00

  • Effects of the 2-Repeat Allele of the DRD4 Gene on Neural Networks Associated With the Prefrontal Cortex in Children With ADHD.

    abstract::Objective: Genetic variation, especially polymorphism of the dopamine D4 receptor gene (DRD4), has been linked to deficits in self-regulation and executive functions and to attention deficit hyperactivity disorder (ADHD), and is related to the structural and functional integrity of the default mode network (DMN), the ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00279

    authors: Qian A,Tao J,Wang X,Liu H,Ji L,Yang C,Ye Q,Chen C,Li J,Cheng J,Wang M,Zhao K

    更新日期:2018-07-12 00:00:00

  • Mindfulness-induced selflessness: a MEG neurophenomenological study.

    abstract::Contemporary philosophical and neurocognitive studies of the self have dissociated two distinct types of self-awareness: a "narrative" self-awareness (NS) weaving together episodic memory, future planning and self-evaluation into a coherent self-narrative and identity, and a "minimal" self-awareness (MS) focused on pr...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00582

    authors: Dor-Ziderman Y,Berkovich-Ohana A,Glicksohn J,Goldstein A

    更新日期:2013-09-24 00:00:00

  • Binding in working memory and frontal lobe in normal aging: is there any similarity with autism?

    abstract::Some studies highlight similarities between Autism Spectrum Disorder (ASD) and healthy aging. Indeed, the decline in older individuals' ability to create a unified representation of the individual features of an event is thought to arise from a disruption of binding within the episodic buffer of working memory (WM) as...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00090

    authors: Lecouvey G,Quinette P,Kalpouzos G,Guillery-Girard B,Bejanin A,Gonneaud J,Abbas A,Viader F,Eustache F,Desgranges B

    更新日期:2015-03-05 00:00:00

  • Systems, Subjects, Sessions: To What Extent Do These Factors Influence EEG Data?

    abstract::Lab-based electroencephalography (EEG) techniques have matured over decades of research and can produce high-quality scientific data. It is often assumed that the specific choice of EEG system has limited impact on the data and does not add variance to the results. However, many low cost and mobile EEG systems are now...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00150

    authors: Melnik A,Legkov P,Izdebski K,Kärcher SM,Hairston WD,Ferris DP,König P

    更新日期:2017-03-30 00:00:00

  • A Meta-Analytic Study of the Neural Systems for Auditory Processing of Lexical Tones.

    abstract::The neural systems of lexical tone processing have been studied for many years. However, previous findings have been mixed with regard to the hemispheric specialization for the perception of linguistic pitch patterns in native speakers of tonal language. In this study, we performed two activation likelihood estimation...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00375

    authors: Kwok VPY,Dan G,Yakpo K,Matthews S,Fox PT,Li P,Tan LH

    更新日期:2017-07-26 00:00:00

  • Spatial and temporal features of superordinate semantic processing studied with fMRI and EEG.

    abstract::The relationships between the anatomical representation of semantic knowledge in the human brain and the timing of neurophysiological mechanisms involved in manipulating such information remain unclear. This is the case for superordinate semantic categorization-the extraction of general features shared by broad classe...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00293

    authors: Costanzo ME,McArdle JJ,Swett B,Nechaev V,Kemeny S,Xu J,Braun AR

    更新日期:2013-07-01 00:00:00

  • Relationship of the Acoustic Startle Response and Its Modulation to Adaptive and Maladaptive Behaviors in Typically Developing Children and Those With Autism Spectrum Disorders: A Pilot Study.

    abstract::Background: Autism spectrum disorder (ASD) is associated with persistent impairments in adaptive functioning across multiple domains of daily life. Thus, investigation of the biological background of both adaptive and maladaptive behaviors may shed light on developing effective interventions for improving social adapt...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00005

    authors: Ebishima K,Takahashi H,Stickley A,Nakahachi T,Sumiyoshi T,Kamio Y

    更新日期:2019-01-22 00:00:00

  • Reliability of EEG Interactions Differs between Measures and Is Specific for Neurological Diseases.

    abstract::Alterations of interaction (connectivity) of the EEG reflect pathological processes in patients with neurologic disorders. Nevertheless, it is questionable whether these patterns are reliable over time in different measures of interaction and whether this reliability of the measures is the same across different patien...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00350

    authors: Höller Y,Butz K,Thomschewski A,Schmid E,Uhl A,Bathke AC,Zimmermann G,Tomasi SO,Nardone R,Staffen W,Höller P,Leitinger M,Höfler J,Kalss G,Taylor AC,Kuchukhidze G,Trinka E

    更新日期:2017-07-05 00:00:00

  • Higher Language Ability is Related to Angular Gyrus Activation Increase During Semantic Processing, Independent of Sentence Incongruency.

    abstract::This study investigates the relation between individual language ability and neural semantic processing abilities. Our aim was to explore whether high-level language ability would correlate to decreased activation in language-specific regions or rather increased activation in supporting language regions during process...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00110

    authors: Van Ettinger-Veenstra H,McAllister A,Lundberg P,Karlsson T,Engström M

    更新日期:2016-03-11 00:00:00

  • Expectation Gates Neural Facilitation of Emotional Words in Early Visual Areas.

    abstract::The current study examined whether emotional expectations gate attention to emotional words in early visual cortex. Color cues informed about word valence and onset latency. We observed a stimulus-preceding negativity prior to the onset of cued words that was larger for negative than for neutral words. This indicates ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00281

    authors: Trauer SM,Müller MM,Kotz SA

    更新日期:2019-08-23 00:00:00

  • Linking neuroscientific research on decision making to the educational context of novice students assigned to a multiple-choice scientific task involving common misconceptions about electrical circuits.

    abstract::Functional magnetic resonance imaging was used to identify the brain-based mechanisms of uncertainty and certainty associated with answers to multiple-choice questions involving common misconceptions about electric circuits. Twenty-two scientifically novice participants (humanities and arts college students) were aske...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00014

    authors: Potvin P,Turmel E,Masson S

    更新日期:2014-01-27 00:00:00

  • Case Report of Dual-Site Neurostimulation and Chronic Recording of Cortico-Striatal Circuitry in a Patient With Treatment Refractory Obsessive Compulsive Disorder.

    abstract::Psychiatric disorders are increasingly understood as dysfunctions of hyper- or hypoconnectivity in distributed brain circuits. A prototypical example is obsessive compulsive disorder (OCD), which has been repeatedly linked to hyper-connectivity of cortico-striatal-thalamo-cortical (CSTC) loops. Deep brain stimulation ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.569973

    authors: Olsen ST,Basu I,Bilge MT,Kanabar A,Boggess MJ,Rockhill AP,Gosai AK,Hahn E,Peled N,Ennis M,Shiff I,Fairbank-Haynes K,Salvi JD,Cusin C,Deckersbach T,Williams Z,Baker JT,Dougherty DD,Widge AS

    更新日期:2020-10-23 00:00:00

  • Subliminal Emotional Words Impact Syntactic Processing: Evidence from Performance and Event-Related Brain Potentials.

    abstract::Recent studies demonstrate that syntactic processing can be affected by emotional information and that subliminal emotional information can also affect cognitive processes. In this study, we explore whether unconscious emotional information may also impact syntactic processing. In an Event-Related brain Potential (ERP...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00192

    authors: Jiménez-Ortega L,Espuny J,de Tejada PH,Vargas-Rivero C,Martín-Loeches M

    更新日期:2017-04-25 00:00:00

  • Focal dystonia in musicians: linking motor symptoms to somatosensory dysfunction.

    abstract::Musician's dystonia (MD) is a neurological motor disorder characterized by involuntary contractions of those muscles involved in the play of a musical instrument. It is task-specific and initially only impairs the voluntary control of highly practiced musical motor skills. MD can lead to a severe decrement in a musici...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00297

    authors: Konczak J,Abbruzzese G

    更新日期:2013-06-25 00:00:00

  • Dopaminergic Control of Attentional Flexibility: Inhibition of Return is Associated with the Dopamine Transporter Gene (DAT1).

    abstract::Genetic variability related to the dopamine (DA) transporter gene (DAT1) has received increasing attention as a possible modulator of human cognition. The 9-repeat allele of the DAT1 gene is presumably associated with higher striatal DA levels than the 10-repeat allele, which might support inhibitory control functions...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00053

    authors: Colzato LS,Pratt J,Hommel B

    更新日期:2010-07-13 00:00:00

  • Using time-to-contact information to assess potential collision modulates both visual and temporal prediction networks.

    abstract::Accurate estimates of the time-to-contact (TTC) of approaching objects are crucial for survival. We used an ecologically valid driving simulation to compare and contrast the neural substrates of egocentric (head-on approach) and allocentric (lateral approach) TTC tasks in a fully factorial, event-related fMRI design. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.010.2008

    authors: Coull JT,Vidal F,Goulon C,Nazarian B,Craig C

    更新日期:2008-09-13 00:00:00

  • Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey.

    abstract::The lateral habenula (LHb) plays an important role in motivational decision making. Neurons in the primate LHb signal negative 'reward prediction errors' and inhibit midbrain dopamine (DA) neurons. These negative reward prediction error signals in the LHb are, at least partly, provided by a distinct group of neurons i...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00778

    authors: Hong S,Hikosaka O

    更新日期:2013-11-13 00:00:00

  • Exploring Training Effect in 42 Human Subjects Using a Non-invasive Sensorimotor Rhythm Based Online BCI.

    abstract::Electroencephalography based brain-computer interfaces (BCIs) show promise of providing an alternative communication channel between the brain and an external device. It is well acknowledged that BCI control is a skill and could be improved through practice and training. In this study, we explore the change of BCI beh...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00128

    authors: Meng J,He B

    更新日期:2019-04-17 00:00:00

  • Cortical microcircuit dynamics mediating binocular rivalry: the role of adaptation in inhibition.

    abstract::Perceptual bistability arises when two conflicting interpretations of an ambiguous stimulus or images in binocular rivalry (BR) compete for perceptual dominance. From a computational point of view, competition models based on cross-inhibition and adaptation have shown that noise is a crucial force for rivalry, and ope...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2011.00145

    authors: Theodoni P,Panagiotaropoulos TI,Kapoor V,Logothetis NK,Deco G

    更新日期:2011-11-28 00:00:00

  • The neural circuitry of expertise: perceptual learning and social cognition.

    abstract::Amongst the most significant questions we are confronted with today include the integration of the brain's micro-circuitry, our ability to build the complex social networks that underpin society and how our society impacts on our ecological environment. In trying to unravel these issues one place to begin is at the le...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00852

    authors: Harré M

    更新日期:2013-12-17 00:00:00

  • Flat vs. Expressive Storytelling: Young Children's Learning and Retention of a Social Robot's Narrative.

    abstract::Prior research with preschool children has established that dialogic or active book reading is an effective method for expanding young children's vocabulary. In this exploratory study, we asked whether similar benefits are observed when a robot engages in dialogic reading with preschoolers. Given the established effec...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00295

    authors: Kory Westlund JM,Jeong S,Park HW,Ronfard S,Adhikari A,Harris PL,DeSteno D,Breazeal CL

    更新日期:2017-06-07 00:00:00

  • Training-induced improvement of response selection and error detection in aging assessed by task switching: effects of cognitive, physical, and relaxation training.

    abstract::Cognitive control functions decline with increasing age. The present study examines if different types of group-based and trainer-guided training effectively enhance performance of older adults in a task switching task, and how this expected enhancement is reflected in changes of cognitive functions, as measured in el...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00130

    authors: Gajewski PD,Falkenstein M

    更新日期:2012-05-11 00:00:00