MicroRNA-205 increases the sensitivity of docetaxel in breast cancer.

abstract：:Lung cancer is one of the most common malignancies worldwide; however, its detailed molecular mechanism remains largely unknown. Long non-coding RNAs (lncRNAs) have been identified to serve critical roles in tumorigenesis. The aim of the present study was to investigate the role of a newly identified lncRNA, overexpre...

journal_title：Oncology letters

authors： Zou Y,Zhang B,Mao Y,Zhang H,Hong W

更新日期：2019-09-01 00:00:00

abstract：:We investigated whether treatment package time was significantly associated with survival outcomes of resectable locally-advanced laryngeal squamous cell carcinoma in patients who consecutively underwent various treatments, including surgery alone and salvage surgery for residual tumor. A total of 100 patients with cl...

journal_title：Oncology letters

authors： Suzuki H,Terada H,Hanai N,Nishikawa D,Koide Y,Beppu S,Kodaira T,Tachibana H,Koide Y,Tanaka H,Hasegawa Y

更新日期：2019-01-01 00:00:00

abstract：:Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and the mechanisms underlying this remain poorly understood. The present study further examined this controv...

journal_title：Oncology letters

authors： Yuan Y,Zhou C,Chen X,Tao C,Cheng H,Lu X

更新日期：2018-06-01 00:00:00

abstract：:The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...

journal_title：Oncology letters

authors： Badr MA,Hassan TH,El-Gerby KM,Lamey ME

更新日期：2013-02-01 00:00:00

abstract：:The clinical effect of interventional therapy on gastric cancer after chemotherapy and effect on inflammatory factors in peripheral blood serum of patients were investigated. A retrospective analysis of 429 patients with gastric cancer treated in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from Jul...

journal_title：Oncology letters

authors： Wu P,Wang J

更新日期：2019-08-01 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...

journal_title：Oncology letters

authors： Zhang X,Li S,Li M,Huang H,Li J,Zhou C

更新日期：2016-08-01 00:00:00

abstract：:Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...

journal_title：Oncology letters

authors： Huang K,Li W,Chen Y,Zhu J

更新日期：2018-12-01 00:00:00

abstract：:The expression levels of cyclooxygenase (COX)-2 and the prostaglandin E2 (PGE2) content have been associated with poor prognosis in patients with colorectal cancer (CRC). There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on t...

journal_title：Oncology letters

authors： Cervantes-Madrid DL,Nagi S,Asting Gustafsson A

更新日期：2017-03-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of cancer-associated mortality in the world. In previous years, almost no significant advancements have been made towards the molecular characterization of NSCLC, which highlights the requirement for novel target genes. Hypoxia inducibl...

journal_title：Oncology letters

authors： Qian J,Bai H,Gao Z,Dong YU,Pei J,Ma M,Han B

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, th...

journal_title：Oncology letters

authors： Shan XY,Xu TT,Liu ZL,Hu XF,Zhang YD,Guo SZ,Wang B

更新日期：2017-08-01 00:00:00

abstract：:Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thy...

journal_title：Oncology letters

authors： Ditsch N,Mayr D,Lenhard M,Strauss C,Vodermaier A,Gallwas J,Stoeckl D,Graeser M,Weissenbacher T,Friese K,Jeschke U

更新日期：2012-10-01 00:00:00

abstract：:The present study reports the case of a 20-year-old female who was identified to have a left renal angiomyolipoma (AML) with hemorrhage. Following temporary conservative observation, the patient received continuous ultrasonic follow-up. Due to the rapid growth of the lesion, further examinations were performed. Comput...

journal_title：Oncology letters

authors： Liang W,Xu S

更新日期：2015-11-01 00:00:00

abstract：:MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell pro...

journal_title：Oncology letters

authors： Hou Y

更新日期：2019-01-01 00:00:00

abstract：:Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, bu...

journal_title：Oncology letters

authors： Liu D,Li R,Guo X,Pang L,Zang Y,Liu K,Chen D

更新日期：2018-06-01 00:00:00

abstract：:Preeclampsia (PE) is characterized by gestational hypertension and proteinuria, and is a leading cause of maternal death and perinatal morbidity globally. Although the exact cause of PE remains unclear, several studies have suggested a role for abnormal expression of multiple genes. The aim of the present study was to...

journal_title：Oncology letters

authors： Xu Z,Wu C,Liu Y,Wang N,Gao S,Qiu S,Wang Z,Ding J,Zhang L,Wang H,Wu W,Wan B,Yu J,Fang J,Yang P,Shao Q

更新日期：2020-08-01 00:00:00

abstract：:Activating mutations of the epidermal growth factor receptor (EGFR) gene are characteristic of non-small cell lung cancer (NSCLC). EGFR mutations were previously detected in histologically normal lung tissue around NSCLC tumors. Computed tomography-guided lung needle biopsy (CTNB) is an accurate and useful technique f...

journal_title：Oncology letters

authors： Ueno T,Soh J,Hiraki T,Asano H,Ichimura K,Shibamoto K,Gobara H,Kanazawa S,Toyooka S,Miyoshi S

更新日期：2012-02-01 00:00:00

abstract：:Prognosis and treatment differences between initial and second primary chondrosarcoma (pCS) remain unknown. In the present study, patients with chondrosarcoma diagnosed between January 2004 and December 2015 were identified using the Surveillance Epidemiology and End Results database. Kaplan-Meier curves and log-rank ...

journal_title：Oncology letters

authors： Mao W,Kong M,Yu H,Wang D,Huang X,Yao X,Fan J,Geng J

更新日期：2019-07-01 00:00:00

abstract：:The expression of macrophage inhibitory cytokine-1 (MIC-1) of early gastric cancer treated using endoscopic mucosal resection (EMR) and its correlation with prognosis were investigated. One hundred and forty-seven patients with early gastric cancer (less than 20 mm in diameter) were recruited and assigned into an obse...

journal_title：Oncology letters

authors： Zhang N,Lu B

更新日期：2017-08-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are enzymes for extracellular matrix remodeling that are involved in tumor growth, progression and metastasis. Among them, MMP-9 has been implicated in tumor angiogenesis. Tissue inhibitor of matrix metalloproteinase (TIMP)-2, a member of the family of MMP inhibitors, induces apoptosis...

journal_title：Oncology letters

authors： Wajner SM,Capp C,Brasil BA,Meurer L,Maia AL

更新日期：2014-03-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder. It is characterized by the presence of the Philadelphia (Ph) chromosome, t(9;22)(q34.1;q11.2), which carries the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have markedly changed the treatment approach of CML and have become the f...

journal_title：Oncology letters

authors： Al-Khallaf H,Alali H,Alkhatti A

更新日期：2018-11-01 00:00:00

abstract：:Controversy exists regarding a possible association between prostatitis and prostate cancer. To further evaluate the incidence of prostate cancer following prostatitis, a study of prostate cancer incidence in a cohort of Finnish men was performed. The original survey evaluating self-reported prostatitis was conducted ...

journal_title：Oncology letters

authors： Vaarala MH,Mehik A,Ohtonen P,Hellström PA

更新日期：2016-08-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of peroxisome proliferator-activated receptor (PPAR)-γ in inflammatory bowel disease (IBD), and to also identify the association between PPAR-γ and the clinical features of patients with IBD. An azoxymethane (AOM)/dextran sodium sulfate (DSS) animal model of ...

journal_title：Oncology letters

authors： Dou X,Xiao J,Jin Z,Zheng P

更新日期：2015-09-01 00:00:00

abstract：:The clinical resistance of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has been linked to EGFR T790M resistance mutations or MET amplifications. Additional mechanisms underlying EGFR-TKI drug resistance remain unclear. The present study demonstrated t...

journal_title：Oncology letters

authors： Zhai Y,Zhang Y,Nan K,Liang X

更新日期：2017-05-01 00:00:00

abstract：:Regenerating islet-derived family, member 4 (REG4, which encodes Reg IV) is a marker for cancer and inflammatory bowel disease. This study aimed to investigate the diagnostic utility of Reg IV measurement in sera from esophageal cancer patients. Reg IV expression was examined in 269 esophageal cancer samples by immuno...

journal_title：Oncology letters

authors： Oue N,Noguchi T,Anami K,Sentani K,Sakamoto N,Uraoka N,Wakamatsu Y,Sasaki H,Yasui W

更新日期：2011-03-01 00:00:00

abstract：:Dendrobium candidum Wall ex Lindl. (D. candidum) is a traditional Chinese medicine widely used in Asia. The present study has showed that D. candidum exerted an anti-metastatic effect in mice injected with 26-M3.1 colon carcinoma cells. D. candidum showed the most marked tumor inhibitory rate of 64.5% at a dose of 400...

journal_title：Oncology letters

authors： Li G,Sun P,Zhou Y,Zhao X,Chen F

更新日期：2014-10-01 00:00:00

abstract：:C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. Increasing evidence has indicated that CXCL5 is involved in the tumorigenesis of various malignancies. The present investigation demonstrated that CXCL5 was ex...

journal_title：Oncology letters

authors： Yang Y,Hou J,Shao M,Zhang W,Qi Y,E S,Wang S,Sui H,Meng D,Wang B,Wang M,Han Y,Cao Y,Huang X,Li Y,Zhang P,Wang W

更新日期：2017-12-01 00:00:00

abstract：:Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...

journal_title：Oncology letters

authors： Zhao ZF,Li JX,Ye R,Wu X,Gao LL,Niu BL

更新日期：2016-02-01 00:00:00

abstract：:Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...

journal_title：Oncology letters

authors： Tang X,Zhang H,Long Y,Hua H,Jiang Y,Jing J

更新日期：2018-09-01 00:00:00

abstract：:The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and pa...

journal_title：Oncology letters

authors： Liu Z,Yang Z,Liu D,Li D,Zou Q,Yuan Y,Li J,Liang L,Chen M,Chen S

更新日期：2014-04-01 00:00:00

abstract：:Glutathione (GSH) is the keystone of the cellular response toward oxidative stress. Elevated GSH content correlates with increased resistance to chemotherapy and radiotherapy of head and neck (HN) tumors. The purpose of the present cross-sectional study was to evaluate whether the expression of glutamate-cysteine liga...

journal_title：Oncology letters

authors： Dequanter D,VAN DE Velde M,Bar I,Nuyens V,Rousseau A,Nagy N,Vanhamme L,Vanhaeverbeek M,Brohée D,Delrée P,Boudjeltia K,Lothaire P,Uzureau P

更新日期：2016-06-01 00:00:00