CCL21 Facilitates Chemoresistance and Cancer Stem Cell-Like Properties of Colorectal Cancer Cells through AKT/GSK-3β/Snail Signals.

abstract：:Bisphenol A (BPA) and its analogues (BPs) are suspected posing potential endocrine disrupting properties. They might migrate into foodstuffs through food packaging materials or contaminated water and soil. Dietary exposure is of paramount importance way for human health. European Food Safety Authority (EFSA) lowered t...

journal_title：Oxidative medicine and cellular longevity

authors： Yao K,Zhang J,Yin J,Zhao Y,Shen J,Jiang H,Shao B

更新日期：2020-12-17 00:00:00

abstract：Background:The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects. Aims:To assess the effect of ileal transposition (IT) and sham types of ...

journal_title：Oxidative medicine and cellular longevity

authors： Skrzep-Poloczek B,Stygar D,Sawczyn T,Romuk E,Chełmecka E,Poloczek J,Dulska A,Kazura W,Karcz KW

更新日期：2018-11-11 00:00:00

abstract：:Mono-(2-ethylhexyl) phthalate (MEHP) and genistein have been classified as endocrine-disrupting chemicals (EDCs) which interfere with the differentiation and development of the male reproductive system. However, how these two EDCs would affect fetal rat testis development at a low dose was rarely studied. In this stud...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang TD,Ma YB,Li HC,Chong T,Wang ZM,Zhang LD

更新日期：2020-05-27 00:00:00

abstract：:TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 an...

journal_title：Oxidative medicine and cellular longevity

authors： Luo Y,Wu JY,Lu MH,Shi Z,Na N,Di JM

更新日期：2016-01-01 00:00:00

abstract：:The present study discusses about the effects of a combination of probiotics able to stimulate the immune system of patients affected by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To this purpose, patients diagnosed according to Fukuda's criteria and treated with probiotics were analyzed by means of ...

journal_title：Oxidative medicine and cellular longevity

authors： Venturini L,Bacchi S,Capelli E,Lorusso L,Ricevuti G,Cusa C

更新日期：2019-11-23 00:00:00

abstract：:Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immun...

journal_title：Oxidative medicine and cellular longevity

authors： Luck C,DeMarco VG,Mahmood A,Gavini MP,Pulakat L

更新日期：2017-01-01 00:00:00

abstract：:Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, prete...

journal_title：Oxidative medicine and cellular longevity

authors： Rudov A,Balduini W,Carloni S,Perrone S,Buonocore G,Albertini MC

更新日期：2014-01-01 00:00:00

abstract：:Over 50% of end-stage renal disease (ESRD) patients die of cardiovascular disease. ESRD patients treated with maintenance hemodialysis are repeatedly exposed to oxidative stress. The aim of the study was to find the relationship between lifestyle factors, nutritional status, calcium-phosphate metabolism, and selected ...

journal_title：Oxidative medicine and cellular longevity

authors： Maraj M,Kuśnierz-Cabala B,Dumnicka P,Gawlik K,Pawlica-Gosiewska D,Gala-Błądzińska A,Ząbek-Adamska A,Ceranowicz P,Kuźniewski M

更新日期：2019-09-05 00:00:00

abstract：:During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade i...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

更新日期：2020-06-17 00:00:00

abstract：:The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular...

journal_title：Oxidative medicine and cellular longevity

authors： Palacios J,Cifuentes F,Valderrama JA,Benites J,Ríos D,González C,Chiong M,Cartes-Saavedra B,Lafourcade C,Wyneken U,González P,Owen GI,Pardo F,Sobrevia L,Buc Calderon P

更新日期：2016-01-01 00:00:00

abstract：:As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-)...

journal_title：Oxidative medicine and cellular longevity

authors： Sajo MEJ,Kim CS,Kim SK,Shim KY,Kang TY,Lee KJ

更新日期：2017-01-01 00:00:00

abstract：:Cardiolipin interacts with many proteins of the mitochondrial inner membrane and, together with cytochrome C and creatine kinase, activates them. It can be considered as an integrating factor for components of the mitochondrial respiratory chain, which provides for an efficient transfer of electrons and protons. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Shilovsky GA,Zverkov OA,Seliverstov AV,Ashapkin VV,Putyatina TS,Rubanov LI,Lyubetsky VA

更新日期：2019-10-24 00:00:00

abstract：:In an attempt to better understand the pathogen-host interaction between invading Mycoplasma ovipneumoniae (M. ovipneumoniae) and sheep airway epithelial cells, biological effects and possible molecular mechanism of capsular polysaccharide of M. ovipneumoniae (CPS) in the induction of cell apoptosis were explored usin...

journal_title：Oxidative medicine and cellular longevity

authors： Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

更新日期：2017-01-01 00:00:00

abstract：:Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We investigated whether the in vivo VNS can protect the liver from IRI....

journal_title：Oxidative medicine and cellular longevity

authors： Xia H,Liu Z,Liang W,Zeng X,Yang Y,Chen P,Zhong Z,Ye Q

更新日期：2020-01-21 00:00:00

abstract：:Obesity is a state of chronic low-level inflammation closely associated with oxidative stress. Childhood obesity is associated with endothelial dysfunction, inflammation, and oxidative stress markers individually. This study was aimed at determining the association between the biomarkers of inflammation, oxidative str...

journal_title：Oxidative medicine and cellular longevity

authors： Selvaraju V,Ayine P,Fadamiro M,Babu JR,Brown M,Geetha T

更新日期：2019-10-16 00:00:00

abstract：:An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes prog...

journal_title：Oxidative medicine and cellular longevity

authors： Zuo L,Hemmelgarn BT,Chuang CC,Best TM

更新日期：2015-01-01 00:00:00

abstract：:Essential oils of some aromatic plants provide an effective nonmedicinal option to control liver fibrosis. Mentha piperita L. essential oil (MPEO) have been reported to possess protective effects against hepatotoxicity. However, its effect against liver fibrosis remains unknown. The present study investigated the anti...

journal_title：Oxidative medicine and cellular longevity

authors： Ogaly HA,Eltablawy NA,Abd-Elsalam RM

更新日期：2018-04-19 00:00:00

abstract：:Doxorubicin (DOX) is an efficient chemotherapeutic agent, but its clinical application is limited by its cardiotoxicity associated with increased oxidative stress. Thus, the combination of DOX and antioxidants has been encouraged. In this study, we evaluated (I) the chemical composition and antioxidant capacity of aqu...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos JM,Alfredo TM,Antunes KÁ,da Cunha JDSM,Costa EMA,Lima ES,Silva DB,Carollo CA,Schmitz WO,Boleti APA,Dos Santos EL,de Picoli Souza K

更新日期：2018-06-28 00:00:00

abstract：:Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death. Mitochondrial functions can be...

journal_title：Oxidative medicine and cellular longevity

authors： Picone P,Nuzzo D,Caruana L,Scafidi V,Di Carlo M

更新日期：2014-01-01 00:00:00

abstract：:Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and in vitro measurement of vascular tone to test a hypothesis that bone morphogenetic protein 4 (BMP4) m...

journal_title：Oxidative medicine and cellular longevity

authors： Yang X,Niu N,Liang C,Wu MM,Tang LL,Wang QS,Lou J,Song BL,Zheng WW,Ma HP,Zhang ZR

更新日期：2020-10-28 00:00:00

abstract：:This paper compiles the beneficial effects of cocoa polyphenols on human health, especially with regard to cardiovascular and inflammatory diseases, metabolic disorders, and cancer prevention. Their antioxidant properties may be responsible for many of their pharmacological effects, including the inhibition of lipid p...

journal_title：Oxidative medicine and cellular longevity

authors： Andújar I,Recio MC,Giner RM,Ríos JL

更新日期：2012-01-01 00:00:00

abstract：:The ability to produce cold plasma at atmospheric pressure conditions was the basis for the rapid growth of plasma-related application areas in biomedicine. Plasma comprises a multitude of active components such as charged particles, electric current, UV radiation, and reactive gas species which can act synergisticall...

journal_title：Oxidative medicine and cellular longevity

authors： Bernhardt T,Semmler ML,Schäfer M,Bekeschus S,Emmert S,Boeckmann L

更新日期：2019-09-03 00:00:00

abstract：:Degradation of oxidized or oxidatively modified proteins is an essential part of the antioxidant defenses of cells. 4-Hydroxy-2-nonenal, a major reactive aldehyde formed by lipid peroxidation, causes many types of cellular damage. It has been reported that 4-hydroxy-2-nonenal-modified proteins are degraded by the ubiq...

journal_title：Oxidative medicine and cellular longevity

authors： Tsuchiya Y,Okada G,Kobayashi S,Chikuma T,Hojo H

更新日期：2011-01-01 00:00:00

abstract：Background:Acute kidney injury (AKI) is one of the common complications of sepsis. Heretofore, there is no effective treatment for septic AKI. Recent studies have revealed that besides treating hematological malignancies, human umbilical cord blood mononuclear cells (hUCBMNCs) show good therapeutic effects on other dis...

journal_title：Oxidative medicine and cellular longevity

authors： Feng LX,Zhao F,Liu Q,Peng JC,Duan XJ,Yan P,Wu X,Wang HS,Deng YH,Duan SB

更新日期：2020-07-28 00:00:00

abstract：:Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consist...

journal_title：Oxidative medicine and cellular longevity

authors： Nascimento CP,Luz DA,da Silva CCS,Malcher CMR,Fernandes LMP,Dalla Santa HS,Gomes ARQ,Monteiro MC,Ribeiro CHMA,Fontes-Júnior EA,Maia CSF

更新日期：2020-07-30 00:00:00

abstract：:Several of the most prevalent etiological factors which contribute towards global death rates are associated with cardiovascular diseases (CVDs), which include a range of conditions such as angina, rheumatic heart disease, and venous thrombosis. Extensive research has been conducted into the role played by oxidative s...

journal_title：Oxidative medicine and cellular longevity

authors： Chen S,Jiang H,Peng H,Wu X,Fang J

更新日期：2017-01-01 00:00:00

abstract：:The placenta plays a vital role in fetal development during pregnancy. Dysfunction of the placenta can be caused by oxidative stress and can lead to abnormal fetal development. Preventing oxidative stress of the placenta is thus an important measure to ensure positive birth outcomes. Research shows that tryptophan and...

journal_title：Oxidative medicine and cellular longevity

authors： Xu K,Liu G,Fu C

更新日期：2018-07-22 00:00:00

abstract：:In recent decades, localized tissue oxidative stress has been implicated as a key component in the development of diabetic retinopathy (DR). Increasing evidence shows that oxidative stress caused by diabetes-induced metabolic abnormalities is the most common mechanism associated with the pathogenesis of DR for both ty...

journal_title：Oxidative medicine and cellular longevity

authors： Wu Y,Tang L,Chen B

更新日期：2014-01-01 00:00:00

abstract：:Oxidative stress has been proven as one of the most critical regulatory mechanisms involved in fine Particulate Matter- (PM2.5-) mediated toxicity. For a better understanding of the underlying mechanisms that enable oxidative stress to participate in PM2.5-induced toxic effects, the current study explored the effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Y,Jin L,Chi Y,Yang J,Zhen Q,Wu H

更新日期：2019-12-07 00:00:00

abstract：:The present study aims to explore the protective effect of human bone marrow mesenchymal stem cells (hBMSCs) on radiation-induced aortic injury (RIAI). hBMSCs were isolated and cultured from human bone marrow. Male C57/BL mice were irradiated with a dose of 18-Gy 6MV X-ray and randomly treated with either vehicle or h...

journal_title：Oxidative medicine and cellular longevity

authors： Shen Y,Jiang X,Meng L,Xia C,Zhang L,Xin Y

更新日期：2018-02-28 00:00:00