Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives.

abstract：:Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae. The animals received either 10 μL of saline or a S. pneumoniae suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7 mg/kg/1 day; placebo with dexamethasone 0.2 mg/kg/7 days; meningitis...

journal_title：Oxidative medicine and cellular longevity

authors： Barichello T,Santos AL,Silvestre C,Generoso JS,Cipriano AL,Petronilho F,Dal-Pizzol F,Comim CM,Quevedo J

更新日期：2011-01-01 00:00:00

abstract：:Picroside II, from the herb Picrorhiza scrophulariiflora Pennell, has antioxidant and anti-inflammatory activities. However, its function on severe acute pancreatitis (SAP) and molecular mechanism remains unknown. The effects of picroside II on the SAP induced by cerulean were investigated. SAP rats were treated with ...

journal_title：Oxidative medicine and cellular longevity

authors： Piao X,Liu B,Guo L,Meng F,Gao L

更新日期：2017-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in the cognitive domains associated with orientation, recording, and memory. This pathology results from an abnormal deposition of the β-amyloid (Aβ) peptide and the intracellular accumulation of neurofibrillary tangles. Mitochondria...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos SM,Romeiro CFR,Rodrigues CA,Cerqueira ARL,Monteiro MC

更新日期：2019-11-30 00:00:00

abstract：:Due to the progressive aging of the society, the prevalence and socioeconomic burden of neurodegenerative diseases are predicted to rise. The most common neurodegenerative disorders nowadays, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, can be classified as proteinopathies. They...

journal_title：Oxidative medicine and cellular longevity

authors： Pichla M,Bartosz G,Sadowska-Bartosz I

更新日期：2020-10-13 00:00:00

abstract：:Metabolic disorders are severe and chronic impairments of the health of many people and represent a challenge for the society as a whole that has to deal with an ever-increasing number of affected individuals. Among common metabolic disorders are Alzheimer's disease, obesity, and type 2 diabetes. These disorders do no...

journal_title：Oxidative medicine and cellular longevity

authors： Rigotto G,Basso E

更新日期：2019-06-16 00:00:00

abstract：:The total lifespan of the yeast Saccharomyces cerevisiae may be divided into two phases: the reproductive phase, during which the cell undergoes mitosis cycles to produce successive buds, and the postreproductive phase, which extends from the last division to cell death. These phases may be regulated by a common mecha...

journal_title：Oxidative medicine and cellular longevity

authors： Zadrag-Tecza R,Kwolek-Mirek M,Alabrudzińska M,Skoneczna A

更新日期：2018-03-20 00:00:00

abstract：:As the involvement of oxidative stress (OS) in autoimmune thrombocytopenia (AITP) has been reported, a fast and rapid test for the reliable measurement of OS and antioxidant capacities (AOCs) might be a useful tool in extending current diagnostic possibilities. The free oxygen radical test (FORT) and free oxygen radic...

journal_title：Oxidative medicine and cellular longevity

authors： Kamhieh-Milz J,Salama A

更新日期：2014-01-01 00:00:00

abstract：:Oxidative stress has been proven as one of the most critical regulatory mechanisms involved in fine Particulate Matter- (PM2.5-) mediated toxicity. For a better understanding of the underlying mechanisms that enable oxidative stress to participate in PM2.5-induced toxic effects, the current study explored the effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Y,Jin L,Chi Y,Yang J,Zhen Q,Wu H

更新日期：2019-12-07 00:00:00

abstract：:Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic eff...

journal_title：Oxidative medicine and cellular longevity

authors： Menini S,Iacobini C,Blasetti Fantauzzi C,Pesce CM,Pugliese G

更新日期：2016-01-01 00:00:00

abstract：:Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial...

journal_title：Oxidative medicine and cellular longevity

authors： Tan S,Wong E

更新日期：2017-01-01 00:00:00

abstract：:Oxidative stress induced by long-term glucocorticoid (GC) use weakens the repair capacity of bone tissue. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase (NOX) is a superoxide-generating enzyme that plays an important role in regulating bone metabolism. To clarify the role of nonphagocytic NO...

journal_title：Oxidative medicine and cellular longevity

authors： Bai SC,Xu Q,Li H,Qin YF,Song LC,Wang CG,Cui WH,Zheng Z,Yan DW,Li ZJ,Li D,Wan X,Zhang HF

更新日期：2019-03-27 00:00:00

abstract：:Sarcopenia is a syndrome characterized by a progressive and generalized skeletal muscle mass and strength loss, as well as a poor physical performance, which as strongly been associated with aging. Sedentary lifestyle in the elderly contributes to this condition; however, physical activity improves health, reducing mo...

journal_title：Oxidative medicine and cellular longevity

authors： Hernández-Álvarez D,Mena-Montes B,Toledo-Pérez R,Pedraza-Vázquez G,López-Cervantes SP,Morales-Salazar A,Hernández-Cruz E,Lazzarini-Lechuga R,Vázquez-Cárdenas RR,Vilchis-DeLaRosa S,Posadas-Rodríguez P,Santín-Márquez R,Rosas-Carras

更新日期：2019-11-11 00:00:00

abstract：:Some evidence indicated that chemoresistance associates with the acquisition of cancer stem-like properties. Recent studies suggested that chemokines can promote the chemoresistance and stem cell properties in various cancer cells, while the underling mechanism is still not completely illustrated. In our study, we fou...

journal_title：Oxidative medicine and cellular longevity

authors： Lu LL,Chen XH,Zhang G,Liu ZC,Wu N,Wang H,Qi YF,Wang HS,Cai SH,Du J

更新日期：2016-01-01 00:00:00

abstract：:Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca2+-activated potassium channel (BKCaα), and annexin A5 (ANXA5), which we verify here by coimmunoprecipitation and double labelling immunocytochemistry. The observation that annexin is flipped to the ou...

journal_title：Oxidative medicine and cellular longevity

authors： Brazier SP,Telezhkin V,Kemp PJ

更新日期：2016-01-01 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Ischemia-reperfusion (I/R) injury caused by acute myocardial infarction (AMI) can initiate a strong inflammatory response. Polymorphonuclear cells (PMNs) are the most important inflammatory cells. Our previous studies found that the calcium-sensing receptor (CaSR) regulates the proinflammatory effects of PMNs. However...

journal_title：Oxidative medicine and cellular longevity

authors： Zhai TY,Cui BH,Zhou Y,Xu XY,Zou L,Lin X,Zhu XS,Zhang SW,Xie WL,Cheng YY,Sun YH

更新日期：2021-01-12 00:00:00

abstract：:Reactive oxygen species (ROS) are generated by sperm metabolism. While, ROS are required for maturation, capacitation and acrosome reaction, they also modify many peroxidable cellular compounds. There is production of ROS during cryopreservation and frozen spermatozoa are highly sensitive to lipid peroxidation (LPO). ...

journal_title：Oxidative medicine and cellular longevity

authors： Cheema RS,Bansal AK,Bilaspuri GS

更新日期：2009-07-01 00:00:00

abstract：:Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on prostacyclin, thromb...

journal_title：Oxidative medicine and cellular longevity

authors： Trettin A,Böhmer A,Suchy MT,Probst I,Staerk U,Stichtenoth DO,Frölich JC,Tsikas D

更新日期：2014-01-01 00:00:00

abstract：:Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses an antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results,...

journal_title：Oxidative medicine and cellular longevity

authors： Ashour AE,Sayed-Ahmed MM,Abd-Allah AR,Korashy HM,Maayah ZH,Alkhalidi H,Mubarak M,Alhaider A

更新日期：2012-01-01 00:00:00

abstract：:Ischemia-reperfusion injury is the second most common injury of the spinal cord and has the risk of neurological dysfunction and paralysis, which can seriously affect patient quality of life. Salidroside (Sal) is an active ingredient extracted from Herba Cistanche with a variety of biological attributes such as antiox...

journal_title：Oxidative medicine and cellular longevity

authors： Gu C,Li L,Huang Y,Qian D,Liu W,Zhang C,Luo Y,Zhou Z,Kong F,Zhao X,Liu H,Gao P,Chen J,Yin G

更新日期：2020-07-23 00:00:00

abstract：:Exercise induced skeletal muscle phenotype change involves a complex interplay between signaling pathways and downstream regulators. This study aims to investigate the effect of acute exercise on mitochondrial H2O2 production and its association with p(66Shc), FOXO3a, and antioxidant enzymes. Male ICR/CD-1 mice were s...

journal_title：Oxidative medicine and cellular longevity

authors： Wang P,Li CG,Qi Z,Cui D,Ding S

更新日期：2015-01-01 00:00:00

abstract：:The etiology of Parkinson's disease (PD) is linked with cellular inclusions in the substantia nigra pars compacta region of the brain that are enriched in the misfolded presynaptic protein α-synuclein (αS) and death of the dopaminergic neurons. Brain iron homeostasis governs both neurotransmission and neurodegeneratio...

journal_title：Oxidative medicine and cellular longevity

authors： Abeyawardhane DL,Lucas HR

更新日期：2019-10-09 00:00:00

abstract：:Nitro-oxidative stress (NOS) plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative disorders, and major depression (MD). The latter is a very frequent psychiatric illness characterized by accelerated aging, neurodegeneration, high comorbidity with age-related disorders, and premature m...

journal_title：Oxidative medicine and cellular longevity

authors： Luca M,Luca A,Calandra C

更新日期：2013-01-01 00:00:00

abstract：:Mitochondria are the main organelles that produce adenosine 5'-triphosphate (ATP) and reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative damage. The irreversible oxidative damage in mitochondria has been implicated in various human diseases. Increasing evidence indicates the thera...

journal_title：Oxidative medicine and cellular longevity

authors： Jiang Q,Yin J,Chen J,Ma X,Wu M,Liu G,Yao K,Tan B,Yin Y

更新日期：2020-12-03 00:00:00

abstract：:Balkan endemic nephropathy (BEN) represents a chronic tubulointerstitial nephropathy which is followed by the progression of kidney fibrosis to end-stage kidney failure. The critical involvement of poisons in food (aristolochic acid (AA), ochratoxin, and heavy metals) and selenium deficiency are among nutritive factor...

journal_title：Oxidative medicine and cellular longevity

authors： Veljković A,Hadži-Đokić J,Sokolović D,Čukuranović R,Čukuranović-Kokoris J,Bašić D,Đorđević B,Stojanović M,Šmelcerović A,Kocić G

更新日期：2020-08-18 00:00:00

abstract：:Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphisms on the ability of...

journal_title：Oxidative medicine and cellular longevity

authors： Liu J,Jia W,Hua RX,Zhu J,Zhang J,Yang T,Li P,Xia H,He J,Cheng J

更新日期：2019-06-25 00:00:00

abstract：:There are several oxidative stress-related pathways interconnecting Alzheimer's disease and type II diabetes, two public health problems worldwide. Coincidences are so compelling that it is attractive to speculate they are the same disorder. However, some pathological mechanisms as observed in diabetes are not necessa...

journal_title：Oxidative medicine and cellular longevity

authors： Rosales-Corral S,Tan DX,Manchester L,Reiter RJ

更新日期：2015-01-01 00:00:00

abstract：Background:Liver transplantation leads to liver ischemia/reperfusion (I/R) injury, resulting in early graft dysfunction and failure. Exacerbations of oxidative stress and inflammatory response are key processes in the development of liver I/R injury. Intravenous anesthetic propofol potent effects on free radical scaven...

journal_title：Oxidative medicine and cellular longevity

authors： Yao W,Han X,Zhang Y,Guan J,Ge M,Chen C,Wu S,Chen J,Luo G,Huang P,Hei Z

更新日期：2018-10-28 00:00:00

abstract：:Some iron chelators display significant anticancer activity that may involve ferritin degradation either in proteasomes or in lysosomes, and the latter might involve ferritinophagy with a period. However, the correlation of ferritinophagy with anticancer activity of iron chelator was not fully determined. Revealing th...

journal_title：Oxidative medicine and cellular longevity

authors： Huang T,Sun Y,Li Y,Wang T,Fu Y,Li C,Li C

更新日期：2018-08-05 00:00:00

abstract：:Wfs1 deficiency leads to a progressive loss of plasma insulin concentration, which should reduce the consumption of glucose in insulin-dependent tissues, causing a variety of changes in intracellular energy metabolism. Our objective here was to assess the changes in the amount and function of mitochondrial proteins in...

journal_title：Oxidative medicine and cellular longevity

authors： Eimre M,Paju K,Peet N,Kadaja L,Tarrend M,Kasvandik S,Seppet J,Ivask M,Orlova E,Kõks S

更新日期：2018-11-21 00:00:00