Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment.

abstract：:Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. TBI is characterized by primary damage resulting from the mechanical forces applied to the head as a direct result of the trauma and by the subsequent secondary injury due to a complex cascade of biochemical event...

journal_title：Oxidative medicine and cellular longevity

authors： Angeloni C,Prata C,Dalla Sega FV,Piperno R,Hrelia S

更新日期：2015-01-01 00:00:00

abstract：Methods:The expression of CD86, CD206, and HIF-1α in the gastric mucosa was evaluated through immunohistochemistry. RAW 264.7 cells were cocultured with H. pylori at various multiplicities of infection (MOIs), and iNOS, CD86, Arg-1, CD206, and HIF-1α expression was detected by Western blot, PCR, and ELISA analyses. ROS...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,Rong J,Lai Y,Tao L,Yuan X,Shu X

更新日期：2020-12-08 00:00:00

abstract：:We explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein E-deficient (ApoE-/-) mice. Our data showed that pu-erh tea consumption markedly reduced early fatty streak formation and the advanced fibrofatty plaque sizes. Additionally, the mean prop...

journal_title：Oxidative medicine and cellular longevity

authors： Xiao Y,He M,Liang X,She J,He L,Liu Y,Zou J,Yuan Z

更新日期：2018-08-23 00:00:00

abstract：:Mono-(2-ethylhexyl) phthalate (MEHP) and genistein have been classified as endocrine-disrupting chemicals (EDCs) which interfere with the differentiation and development of the male reproductive system. However, how these two EDCs would affect fetal rat testis development at a low dose was rarely studied. In this stud...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang TD,Ma YB,Li HC,Chong T,Wang ZM,Zhang LD

更新日期：2020-05-27 00:00:00

abstract：:Serine-threonine kinase receptor-associated protein (STRAP) is a transforming growth factor β (TGF-β) receptor-interacting protein that has been implicated in both cell proliferation and cell death in response to various stresses. However, the precise roles of STRAP in these cellular processes are still unclear. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Manoharan R,Seong HA,Ha H

更新日期：2018-04-19 00:00:00

abstract：:The antiamnesic effect of 3,5-dicaffeoylquinic acid (3,5-diCQA) as the main phenolic compound in Artemisia argyi H. extract on cognitive dysfunction induced by trimethyltin (TMT) (7.1 μg/kg of body weight; intraperitoneal injection) was investigated in order to assess its ameliorating function in mice. In several beha...

journal_title：Oxidative medicine and cellular longevity

authors： Kang JY,Park SK,Guo TJ,Ha JS,Lee DS,Kim JM,Lee U,Kim DO,Heo HJ

更新日期：2016-01-01 00:00:00

abstract：:Flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD) are two redox cofactors of pivotal importance for mitochondrial functionality and cellular redox balance. Despite their relevance, the mechanism by which intramitochondrial NAD(H) and FAD levels are maintained remains quite unclear in Saccha...

journal_title：Oxidative medicine and cellular longevity

authors： Giancaspero TA,Locato V,Barile M

更新日期：2013-01-01 00:00:00

abstract：:Curcumin is a natural polyphenolic compound widely known to have antioxidant, anti-inflammatory, and antiapoptotic properties. In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneratio...

journal_title：Oxidative medicine and cellular longevity

authors： Khan MS,Muhammad T,Ikram M,Kim MO

更新日期：2019-11-07 00:00:00

abstract：:Fruits, such as grapes, are essential food of the Mediterranean diet. Grape extracts have potent antioxidant and chemopreventive properties in vitro. Numerous studies have examined the effects of plant extract administration on redox status at rest in animals and humans but their results are controversial. However, th...

journal_title：Oxidative medicine and cellular longevity

authors： Veskoukis AS,Kyparos A,Nikolaidis MG,Stagos D,Aligiannis N,Halabalaki M,Chronis K,Goutzourelas N,Skaltsounis L,Kouretas D

更新日期：2012-01-01 00:00:00

abstract：:Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66Shc adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis by providing oxidativ...

journal_title：Oxidative medicine and cellular longevity

authors： Pérez H,Finocchietto PV,Alippe Y,Rebagliati I,Elguero ME,Villalba N,Poderoso JJ,Carreras MC

更新日期：2018-03-12 00:00:00

abstract：:Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy and chemotherapy are modest. Although targeted therapy and immunotherapy have been a topic of significant research in recent years, scientific developments have not yet translated to significant i...

journal_title：Oxidative medicine and cellular longevity

authors： He Z,Zhang H,Li H,Wang Y,Qian J,Cai X,Sun L,Huang J

更新日期：2020-11-05 00:00:00

abstract：:There is little research on how cooking and digestion affect the anti-inflammatory activity of culinary herbs. Thus, the aim of this paper was to investigate this activity following cooking and in vitro digestion of the common culinary herbs, rosemary, sage, and thyme, and the relationship between their anti-inflammat...

journal_title：Oxidative medicine and cellular longevity

authors： Chohan M,Naughton DP,Jones L,Opara EI

更新日期：2012-01-01 00:00:00

abstract：:The main properties and biological effects of the antioxidant carnosine, the natural dipeptide β-alanyl-L-histidine, are considered. Data on the effective use of carnosine in different pathologies are presented. Special attention is paid to issues of use of carnosine in neurologic and mental diseases, in alcoholism as...

journal_title：Oxidative medicine and cellular longevity

authors： Prokopieva VD,Yarygina EG,Bokhan NA,Ivanova SA

更新日期：2016-01-01 00:00:00

abstract：:The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear f...

journal_title：Oxidative medicine and cellular longevity

authors： Fuyuno Y,Uchi H,Yasumatsu M,Morino-Koga S,Tanaka Y,Mitoma C,Furue M

更新日期：2018-02-14 00:00:00

abstract：:As a core member of p38 MAPK signal transduction pathway, p38 regulated/activated kinase (PRAK) is activated by cellular stresses. However, the function of PRAK and its downstream interacting partner remain undefined. Using a yeast two-hybrid system, we identified DJ-1 as a potential PRAK interacting protein. We furth...

journal_title：Oxidative medicine and cellular longevity

authors： Tang J,Liu J,Li X,Zhong Y,Zhong T,Liu Y,Wang JH,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:Renal ischemia-reperfusion injury (RIRI) refers to a phenomenon associated with dysfunction of the kidney and tissue damage. Unfortunately, no specific drugs have been found that effectively prevent and treat RIRI. Curcumin (Cur), a polyphenol extracted from turmeric, possesses a variety of biological activities invol...

journal_title：Oxidative medicine and cellular longevity

authors： Wang ZH,Deng LH,Chi CW,Wang H,Huang YY,Zheng Q

更新日期：2020-11-12 00:00:00

abstract：:The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy f...

journal_title：Oxidative medicine and cellular longevity

authors： Barquilha CN,Santos NJ,Monção CCD,Barbosa IC,Lima FO,Justulin LA,Pértega-Gomes N,Felisbino SL

更新日期：2020-01-20 00:00:00

abstract：:Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor furoxan moiety (NO-ED...

journal_title：Oxidative medicine and cellular longevity

authors： Chiazza F,Chegaev K,Rogazzo M,Cutrin JC,Benetti E,Lazzarato L,Fruttero R,Collino M

更新日期：2015-01-01 00:00:00

abstract：:Free radical-mediated damage to macromolecules and the resulting oxidative modification of different cellular components are a common feature of aging, and this process becomes much more pronounced in age-associated pathologies, including Alzheimer disease (AD). In particular, proteins are particularly sensitive to ox...

journal_title：Oxidative medicine and cellular longevity

authors： Tramutola A,Di Domenico F,Barone E,Perluigi M,Butterfield DA

更新日期：2016-01-01 00:00:00

abstract：:Essential oils of some aromatic plants provide an effective nonmedicinal option to control liver fibrosis. Mentha piperita L. essential oil (MPEO) have been reported to possess protective effects against hepatotoxicity. However, its effect against liver fibrosis remains unknown. The present study investigated the anti...

journal_title：Oxidative medicine and cellular longevity

authors： Ogaly HA,Eltablawy NA,Abd-Elsalam RM

更新日期：2018-04-19 00:00:00

abstract：:Sphingosine kinase (SphK) exhibits two isoforms, SphK1 and SphK2. Both forms catalyze the synthesis of sphingosine 1-phosphate (S1P), a sphingolipid involved in ischemic preconditioning (IPC). Since the ratio of SphK1:SphK2 changes dramatically with aging, it is important to assess the role of SphK2 in IR injury and I...

journal_title：Oxidative medicine and cellular longevity

authors： Vessey DA,Li L,Jin ZQ,Kelley M,Honbo N,Zhang J,Karliner JS

更新日期：2011-01-01 00:00:00

abstract：:GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA ...

journal_title：Oxidative medicine and cellular longevity

authors： Bartlett DB,Slentz CA,Connelly MA,Piner LW,Willis LH,Bateman LA,Granville EO,Bales CW,Huffman KM,Kraus WE

更新日期：2017-01-01 00:00:00

abstract：:Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses an antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results,...

journal_title：Oxidative medicine and cellular longevity

authors： Ashour AE,Sayed-Ahmed MM,Abd-Allah AR,Korashy HM,Maayah ZH,Alkhalidi H,Mubarak M,Alhaider A

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to evaluate the properties of internal components of erythrocytes in chronic renal failure (CRF) patients undergoing hemodialysis (HD) in comparison to control subjects. For investigation of conformational state of hemoglobin and nonheme proteins (NHP) the maleimide spin label (MSL) in electr...

journal_title：Oxidative medicine and cellular longevity

authors： Pieniazek A,Gwozdzinski K

更新日期：2015-01-01 00:00:00

abstract：:Oxidative stress is involved in the development of carotid body (CB) chemosensory potentiation and systemic hypertension induced by chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea. We tested whether peroxynitrite (ONOO(-)), a highly reactive nitrogen species, is involved in the enhanced...

journal_title：Oxidative medicine and cellular longevity

authors： Moya EA,Arias P,Varela C,Oyarce MP,Del Rio R,Iturriaga R

更新日期：2016-01-01 00:00:00

abstract：:Andrographolide (Andro), a major bioactive component obtained from Andrographis paniculata Nees, has exerted wide antioxidant as well as cytoprotective properties. However, whether Andro treatment could retard the progress of diabetic cardiomyopathy (DCM) remains unknown. In this study, we evaluated the effects of And...

journal_title：Oxidative medicine and cellular longevity

authors： Liang E,Liu X,Du Z,Yang R,Zhao Y

更新日期：2018-06-25 00:00:00

abstract：:Tau, a microtubule-associated protein expressed in mature neurons, interacts with tubulin to promote the assembly and stabilization of microtubules. However, abnormally hyperphosphorylated tau dissociates from microtubules and self-aggregates. Tau aggregates, including paired helical filaments and neurofibrillary tang...

journal_title：Oxidative medicine and cellular longevity

authors： Shin SJ,Park YH,Jeon SG,Kim S,Nam Y,Oh SM,Lee YY,Moon M

更新日期：2020-06-30 00:00:00

abstract：:Undiminishing actuality of enzyme modification for therapeutic purposes has been confirmed by application of modified enzymes in clinical practice and numerous research data on them. Intravenous injection of the superoxide dismutase-chondroitin sulfate-catalase (SOD-CHS-CAT) conjugate in preventive and medicative regi...

journal_title：Oxidative medicine and cellular longevity

authors： Maksimenko AV

更新日期：2016-01-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is a Ca+2-permeable channel expressed on neuronal and nonneuronal cells, known as an oxidative stress sensor. It plays a protective role in bacterial infection, and recent findings indicate that this receptor modulates monocyte populations in mice with malaria; however,...

journal_title：Oxidative medicine and cellular longevity

authors： Pereira DMS,Teixeira SA,Murillo O,Peixoto EPM,Araújo MC,Sousa NCF,Monteiro-Neto V,Calixto JB,Cunha TM,Marinho CRF,Muscará MN,Fernandes ES

更新日期：2019-05-16 00:00:00

abstract：:Mitochondrial unfolding protein response (UPRmt) effectively resists the pathological cardiac hypertrophy and improves the mitochondrial function. However, the specific activation mechanism and drugs that can effectively activate UPRmt in the cardiac muscle are yet to be elucidated. The aim of this study was to determ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang B,Tan Y,Zhang Z,Feng P,Ding W,Wang Q,Liang H,Duan W,Wang X,Yu S,Liu J,Yi D,Sun Y,Yi W

更新日期：2020-12-26 00:00:00