Delayed extinction fails to reduce skin conductance reactivity to fear-conditioned stimuli.

Abstract:

:A brief 10-min time delay between an initial and subsequent exposure to extinction trials has been found to impair memory reconsolidation in fear-conditioned rodents and humans, providing a potential means to reduce fearfulness in anxiety disorders and posttraumatic stress disorder (PTSD). The present study used videos of biologically prepared, conditioned stimuli (tarantulas) to test the efficacy of delayed extinction in blocking reconsolidation of conditioned fear in healthy young adults. Strong differential conditioning, measured by skin conductance, was observed among a screened subset of participants during acquisition. However, the delayed-extinction intervention failed to reduce reactivity to the conditioned stimulus paired with the extinction delay. These results are partially consistent with other recent, mixed findings and point to a need for testing other candidate interventions designed to interfere with the reconsolidation process.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Fricchione J,Greenberg MS,Spring J,Wood N,Mueller-Pfeiffer C,Milad MR,Pitman RK,Orr SP

doi

10.1111/psyp.12687

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1343-51

issue

9

eissn

0048-5772

issn

1540-5958

journal_volume

53

pub_type

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