Abstract：
:Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague-Dawley rats was achieved by a low dose of streptozotocin (STZ) (25mg/kgbw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500mg/kg bw) of P. niruri via metabolomics approach. The administration of 500mg/kgbw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Mediani A,Abas F,Maulidiani M,Khatib A,Tan CP,Ismail IS,Shaari K,Ismail A,Lajis NHdoi
10.1016/j.jpba.2016.06.003subject
Has Abstractpub_date
2016-09-05 00:00:00pages
302-312eissn
0731-7085issn
1873-264Xpii
S0731-7085(16)30320-Xjournal_volume
128pub_type
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journal_title：Journal of pharmaceutical and biomedical analysis
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