Abstract：
:The angiotensin converting enzyme inhibitor, enalaprilat can exist in solution as cis and trans conformers which interconvert around the amide bond at room temperature. A HPLC with UV detection was performed to study the influence of various chromatographic operational conditions on both rotamers separation and elution of enalaprilat as a single peak. In addition nuclear overhauser enhancement difference was used for the identification of the conformers. The isomer ratio integrated from the obtained 1H NMR result were 71.5:28.5 and 76:24 at 298 and 279 K, respectively where the trans was the major form.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Bouabdallah S,Trabelsi H,Ben Dhia T,Sabbah S,Bouzouita K,Khaddar Rdoi
10.1016/s0731-7085(02)00661-1subject
Has Abstractpub_date
2003-03-26 00:00:00pages
731-41issue
4eissn
0731-7085issn
1873-264Xpii
S0731708502006611journal_volume
31pub_type
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