Abstract：
:Gas chromatography-mass spectrometry (GC-MS) and high performance liquid chromatography (HPLC) offer highly efficient and potentially sensitive separation and detection techniques. This work describes the quantification of aminoglutethimide (AG) in nanocapsules suspension with both techniques. The analysis of different lots containing known concentrations of drug (1, 2, 3 and 4 mg ml(-1)) were used to investigate the quantitative capabilities of both chromatographic techniques. Both chromatographic methods were successful and on an analytical point of view the validations of aminoglutethimide dosing were suitable in both cases. In routine, the determination of the quality of nanocapsules suspension could be preferentially evaluated by difference between total AG concentration in suspension (evaluated by direct HPLC measure of the suspension diluted in acetonitrile) and free AG concentration (evaluated by direct HPLC measure of simple dilution of the supernatant).
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Berrabah M,Andre D,Verite P,Zahidi A,Lafont Odoi
10.1016/j.jpba.2004.02.030subject
Has Abstractpub_date
2004-06-29 00:00:00pages
761-8issue
4eissn
0731-7085issn
1873-264Xpii
S0731708504001189journal_volume
35pub_type
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