Abstract:
:Two HPLC systems have been developed for the investigation of flumecinol (3-trifluoromethyl-alpha-ethyl-benzhydrol). The reversed-phase system (LiChrosorb RP-18; methanol-water, 7:3, v/v) enables the isolation and identification of the impurities. The chiral system (Chiralcel OD; hexane-2-propanol, 98:2, v/v) separates the enantiomers of flumecinol and its impurities. The potential of spectral convolution in peak identification in HPLC impurity profiling is demonstrated by an example involving the identification of the 4'-methyl-analogue of flumecinol.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Görög S,Herényi B,Rényei Mdoi
10.1016/0731-7085(91)80088-qsubject
Has Abstractpub_date
1992-10-01 00:00:00pages
831-5issue
10-12eissn
0731-7085issn
1873-264Xpii
0731-7085(91)80088-Qjournal_volume
10pub_type
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