Abstract:
:Polysorbate 80 is used in the pharmaceutical industry as an additive to enhance the solubility of non-polar compounds in formulation design and during dissolution analysis. In this paper we present the spectroscopic and chromatographic characteristics for a series of commercially available sources of this non-ionic surfactant. The large UV/vis absorbance and broad chromatographic elution of Polysorbate 80 often makes it difficult to accurately quantitate pharmaceutically active compounds in solutions where the surfactant is present. Boundary conditions have been established where analytical interferences can be avoided in spectrophotometric analysis by choice of analysis wavelength and solution concentrations. Chromatographic method development is also presented enabling the removal of Polysorbate interference in instances where spectroscopic interference is too great.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Wuelfing WP,Kosuda K,Templeton AC,Harman A,Mowery MD,Reed RAdoi
10.1016/j.jpba.2006.01.020subject
Has Abstractpub_date
2006-06-07 00:00:00pages
774-82issue
3eissn
0731-7085issn
1873-264Xpii
S0731-7085(06)00059-8journal_volume
41pub_type
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journal_title:Journal of pharmaceutical and biomedical analysis
pub_type: 杂志文章,评审
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