Abstract：
:The use of multivariate spectrophotometric calibration is reported for the analysis of two decongestant tablets, where paracetamol is the principal component and diphenhydramine or phenylpropanolamine are the minor components. The resolution of these mixtures has been accomplished without prior separation or derivatisation, by using partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. Although the molar ratios of paracetamol to the minor components were 38:1 and 25:1 respectively, the latter have been determined with high accuracy and precision, and with no interference from tablet excipients. PLS is able to take into account small deviations of paracetamol from linearity in the studied concentration range. The application of classical least-squares (CLS) analysis yields unsatisfactory results, due to the low absorbances of the minor components within the range where all components obey Beer's law.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Goicoechea HC,Olivieri ACdoi
10.1016/s0731-7085(99)00029-1subject
Has Abstractpub_date
1999-06-01 00:00:00pages
255-61issue
1-2eissn
0731-7085issn
1873-264Xpii
S0731-7085(99)00029-1journal_volume
20pub_type
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