Abstract:
:Simple and express coulometric method for the evaluation of the total antioxidant capacity (TAC) of human plasma based on the reaction with electrogenerated bromine is applied. TAC of plasma from patients with different ethiology of chronic renal failure was observed. The levels of antioxidant capacity for venous and arterial plasma are authentically different (15+/-1 kCl/L versus 11.7+/-0.7 kCl/L, p<0.01). The application of Vitamin E and ximedon as an antioxidant treatment significantly increase TAC level of plasma. Free liposoluble antioxidants in plasma in alpha-tocopherol units was determined. Redox potential of plasma is measured and its correlation with lg(TAC) is obtained. Transition metal contents of Fe, Cu, Mn, Ni, and Cr in plasma of patients with chronic renal failure is significantly higher than that for a control group. Correlation analysis has shown negative linear regression between TAC value and transition metals concentration in plasma. This confirms interrelation of processes with participation of free radicals, antioxidants and transition metals as donors of electrons in chain radical processes. Moreover, it shows utility of common parameters, TAC for example, for estimation of efficiency of antioxidant defense system in living organism, in particular its antioxidant status.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Ziyatdinova GK,Voloshin AV,Gilmutdinov AKh,Budnikov HC,Ganeev TSdoi
10.1016/j.jpba.2005.08.017subject
Has Abstractpub_date
2006-03-03 00:00:00pages
958-63issue
4eissn
0731-7085issn
1873-264Xpii
S0731-7085(05)00574-1journal_volume
40pub_type
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