Abstract:
:Three impurities were detected in the LC/MS analysis of fluconazole bulk drug substance. Two of the impurities were unknowns having not been reported previously. Structural assignment of these impurities was carried out by LC/MS/MS using electrospray ionization source and an ion trap mass analyzer. Structural elucidation using nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy was facilitated by newly developed rapid preparative isolation method. These impurities were characterized as 1-(1-H-1,2,4-triazole-1-yl) propane-2,3-diol and Z-2-(2,4-difluorophenyl)-3-(1-H-1,2,4-triazole-1-yl)-2-propen-1-ol. Their formation and synthesis are discussed.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Dongre VG,Karmuse PP,Ghugre PD,Salunke SM,Panda N,Kumar Adoi
10.1016/j.jpba.2006.04.012subject
Has Abstractpub_date
2006-09-26 00:00:00pages
334-40issue
3eissn
0731-7085issn
1873-264Xpii
S0731-7085(06)00320-7journal_volume
42pub_type
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