The application of strong cation exchange high-performance liquid chromatography to drug analysis.

abstract：:This study explores the potential of 177Lu-labeled carbon nanospheres as radio-nanoprobes for molecular imaging and therapy. The carboxyl functionalized surface of carbon nanospheres (CNS) was conjugated with [Gly-Gly-Gly-c(Asn-Gly-Arg)], G3-cNGR peptide through amide bond for targeting tumor vasculature and with [2-(...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Vats K,Satpati AK,Sharma R,Sarma HD,Satpati D,Dash A

更新日期：2018-04-15 00:00:00

abstract：:Counterfeit and/or imitation medicines are becoming a major health problem not only in developing countries but also in wealthier countries. The need of new and easy analytical methods for quality control of drugs is essential. We describe the use of Raman spectroscopy, 1H nuclear magnetic resonance (NMR) and 2D diffu...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Trefi S,Routaboul C,Hamieh S,Gilard V,Malet-Martino M,Martino R

更新日期：2008-05-12 00:00:00

abstract：:Free D-aspartate and D-serine occur at substantial levels in the mammalian brain. D-Serine is a physiological endogenous co-agonist for synaptic N-Methyl D-Aspartate (NMDA) receptors (NMDARs), and is involved in the pathophysiology of schizophrenia. Much less is known about the biological meaning of D-aspartate. D-Asp...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Errico F,Mothet JP,Usiello A

更新日期：2015-12-10 00:00:00

abstract：:The FT-Raman quantification of atorvastatin calcium in tablets was performed using the partial least squares (PLS), principal component regression (PCR) and counter-propagation artificial neural networks (CP-ANN) methods. To compare the predictive abilities of the elaborated models, the relative standard errors of pre...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mazurek S,Szostak R

更新日期：2009-01-15 00:00:00

abstract：:Michaelis constant of enzymatic reaction was evaluated by affinity capillary electrophoresis using beta-galactosidase as a model enzyme and o- and p-isomers of nitrophenyl-beta-galactoside as substrates. The enzyme was immobilized on the inner surface of a fused-silica capillary by the covalent bonding through a bridg...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Yoshimoto Y,Shibukawa A,Sasagawa H,Nitta S,Nakagawa T

更新日期：1995-04-01 00:00:00

abstract：:A study was carried out to investigate compatibility of atenolol, a beta(1) blocker, with a variety of pharmaceutical excipients. The binary mixtures (1:1) of atenolol with the excipients were stored for 1 month at 40 degrees C/75% RH. The samples were directly observed for the physical changes, and also analyzed by a...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kumar V,Shah RP,Malik S,Singh S

更新日期：2009-05-01 00:00:00

abstract：:Unfractioned Heparins (UFH) and Low Molecular Weight Heparins (LMWHs) are non-chromophoric, high charged sulphated molecules which are difficult to elute and detect with conventional liquid chromatography methods. Moreover, the detection of LMWHs at low concentration level, like in samples coming from dissolution test...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Abballe F,Lombardi M,Maccone I,Palazzo G,Severoni A,Travaini S,Venturini A

更新日期：2008-09-29 00:00:00

abstract：:In LC method development, the choice of suitable experimental conditions is often challenging for the analyst because of the huge diversity of stationary phases, mobile phase pH and organic modifiers, that could significantly alter the selectivity. The influence of these parameters on selectivity was experimentally te...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Ruta J,Boccard J,Cabooter D,Rudaz S,Desmet G,Veuthey JL,Guillarme D

更新日期：2012-04-07 00:00:00

abstract：:Three impurities were detected in the LC/MS analysis of fluconazole bulk drug substance. Two of the impurities were unknowns having not been reported previously. Structural assignment of these impurities was carried out by LC/MS/MS using electrospray ionization source and an ion trap mass analyzer. Structural elucidat...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Dongre VG,Karmuse PP,Ghugre PD,Salunke SM,Panda N,Kumar A

更新日期：2006-09-26 00:00:00

abstract：:Forced degradation/stress degradation studies of ibrutinib drug were done in hydrolytic (acidic, alkaline and neutral), thermal, photolytic and oxidative degradation conditions in different temperature conditions as per International Conference on Harmonization (ICH) guideline Q1A(R2) in order to identify and characte...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mehta L,Naved T,Grover P,Bhardwaj M,Mukherjee D

更新日期：2021-02-05 00:00:00

abstract：:A method for measuring a human immunodeficiency virus (HIV) cell membrane fusion inhibitor (T-20/Ro 29-9800) and its metabolite (M-20/Ro 50-6343) in human plasma by liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed. The relatively large peptide analytes and their corresponding deuterated (d(10)) ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Chang D,Kolis SJ,Linderholm KH,Julian TF,Nachi R,Dzerk AM,Lin PP,Lee JW,Bansal SK

更新日期：2005-07-01 00:00:00

abstract：:6-O-Succinil-beta-cyclodextrin (CDsuc6) was synthesized with very good yield by one pot synthesis and characterized by NMR spectroscopy and ESI-MS. It was used as a chiral selector in capillary electrophoresis to resolve catecholamine racemates, namely norepinephrine, epinephrine, terbutaline and norphenilephrine. The...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Cucinotta V,Giuffrida A,Maccarrone G,Messina M,Puglisi A,Torrisi A,Vecchio G

更新日期：2005-04-29 00:00:00

abstract：:The shelf-life of a drug is usually determined by fitting the assayed values of drug potency versus time to a linear least-squares model. In least-squares models, the parameters are estimated by minimizing the sum of squares of the residuals. Shelf-life is estimated as the time corresponding to the intersection point ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Roy T

更新日期：1993-09-01 00:00:00

abstract：:Capillary zone electrophoresis is a technique that is rapidly gaining popularity in the pharmaceutical industry because of the wide range of compounds applicable to the technique. These range from small biologically active molecules through to large nucleotides and proteins. This review outlines the historical develop...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Smith NW,Evans MB

更新日期：1994-05-01 00:00:00

abstract：:Statistical modelling and experimental design (SMED) are essential tools for the development and understanding of complicated products and processes. SMED allows efficient experimentation in which all or a large subset of factors are together varied over a set of experiments, in contrast to the traditional approach of...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kettaneh-Wold N

更新日期：1991-01-01 00:00:00

abstract：:The lipophilic character of some benzimidazole and benztriazole derivatives was studied. The classical R(Mo) values were compared with the factors scores obtained by principal component analysis (PCA) based also onto the TLC retention data. The very high correlation between the R(Mo) values and slopes (specific hydrop...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Sârbu C,Djaković-Sekulić T,Perisić-Janjić N

更新日期：2002-10-15 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics (PK/PD) of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme (ACE) inhibitor, were investigated. Imidapril was infused subcutaneously for 4 weeks via an osmotic pump implanted under the skin in the back of male spontaneously hypertensive rats ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Yamanaka K,Takehara N,Murata K,Banno K,Sato T

更新日期：1997-08-01 00:00:00

abstract：:Atomic spectrometry, specifically inductively coupled plasma atomic emission spectrometry (ICP-AES) and mass spectrometry (ICP-MS) show promise for heteroatom-based detection of pharmaceutical compounds. The combination of ultrasonic nebulization (USN) with membrane desolvation (MD) greatly enhances detection limits w...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Carr JE,Kwok K,Webster GK,Carnahan JW

更新日期：2006-01-23 00:00:00

abstract：:A method of reducing disturbing peaks in LC-chromatograms is described. The technique, here called digital subtraction chromatography (DSCh), makes use of the new generation of integrating chromatographic data processors. These processors are able to store the LC-detector signal and then subtract one chromatogram from...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Wiese B

更新日期：1989-01-01 00:00:00

abstract：:Highly sensitive nanosensors such as graphene oxide/ platinum-iridium nanohybrid, carboxylic acid functionalized multiwalled carbon nanotubes (GO/Pt-Ir/MWCNT-COOH) and amine functionalized multiwalled carbon nanotubes (GO/Pt-Ir/MWCNT-NH2) modified glassy carbon electrode were developed for the determination of 5-hydro...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kaya SI,Demirkan B,Bakirhan NK,Kuyuldar E,Kurbanoglu S,Ozkan SA,Sen F

更新日期：2019-09-10 00:00:00

abstract：:A molecularly imprinted electrochemical sensor for toltrazuril (TZR) detection based on molecularly imprinted polymers (MIPs) immobilized on reduced graphene oxide (rGO) and titanium dioxide (TiO2) modified platinum (Pt) electrode surface was fabricated for the first time. The synergistic fast electron transfer abilit...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Huang X,Wei S,Yao S,Zhang H,He C,Cao J

更新日期：2019-02-05 00:00:00

abstract：:Dihydropyridine (DHP) derivatives, as calcium channel blockers with cardiovascular activity, are highly photosensitive and converted in the presence of light to compounds that are inactive. In this work, a self-modeling curve resolution method was applied to study the photodegradation kinetics of nitrendipine and felo...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Javidnia K,Hemmateenejad B,Miri R,Saeidi-Boroujeni M

更新日期：2008-02-13 00:00:00

abstract：:The development and validation of an HPLC method for the quantification of the decapeptide Cetrorelix (acetyl-D-2-naphthylalanyl-D-4-chlorphenylalanyl-D-3-pyridylalanyl-seryl-tyrosyl-D-citrullyl-leucyl-arginyl-prolyl-d-alaninamide), a potent antagonist of the luteinising hormone-releasing hormone in liposome dispersio...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Grohganz H,Schläfli O,Rischer M,Brandl M

更新日期：2004-03-10 00:00:00

abstract：:The concentration of TiO(2) in a cream formulation has been non-destructively measured using Raman spectroscopy without further sample pretreatments. The distribution of TiO(2) particles in a highly viscous cream may not be homogeneous on a microscopic scale and local aggregation of the particles is possible; therefor...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Oh C,Yoon S,Kim E,Han J,Chung H,Jeong HJ

更新日期：2010-11-02 00:00:00

abstract：:The Xiao-Xu-Ming decoction (XXMD) is a traditional Chinese medicine prescription that is clinically used for the treatment of stroke. The active fraction of XXMD (AF-XXMD) exhibits pharmacological effects that are similar to those of XXMD. In this study, 21 primary compounds of AF-XXMD with potential anti-ischemic-str...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Wang C,Jia Z,Wang Z,Hu T,Qin H,Du G,Wu C,Zhang J

更新日期：2016-04-15 00:00:00

abstract：:The Sceletium plant has been reported to contain psychoactive alkaloids, specifically mesembrine, mesembrenone, mesembrenol and other related alkaloids. Sceletium is marketed through health shops and on the internet as dried plant powder and as pharmaceutical dosage forms. The objectives of this research was to develo...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Patnala S,Kanfer I

更新日期：2008-09-29 00:00:00

abstract：:Salvianolic acid B (SAB), tanshinone IIA (TS), ginsenoside Rb₁ (Rb₁), ginsenoside Rg₁ (Rg₁) and notoginsenoside R₁ (R₁) are major active ingredients of Fufang Danshen preparation (FDP) for its protective effects on myocardial ischemia. This study investigated the pharmacokinetics of marker compounds after oral adminis...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Yang S,Zhang K,Lin X,Miao Y,Meng L,Chen W,Tang X

更新日期：2012-08-01 00:00:00

abstract：:A limited number of studies with application of the Arrhenius equation have been reported to drugs and biopharmaceuticals in biological fluids at frozen temperatures. This paper describes stability studies of ampicillin and cephalexin in aqueous solution and human plasma applying the Arrhenius law for determination of...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： do Nascimento TG,de Jesus Oliveira E,Basílio Júnior ID,de Araújo-Júnior JX,Macêdo RO

更新日期：2013-01-25 00:00:00

abstract：:A sensitive method for the analysis of unconjugated morphine, codeine, normorphine and total morphine after hydrolysis of glucuronide conjugates is described. The method was applicable to 50-microliters volumes of plasma. The analytes were converted to heptafluorobutyryl (HFB) derivatives before analysis by gas chroma...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Watson DG,Su Q,Midgley JM,Doyle E,Morton NS

更新日期：1995-01-01 00:00:00

abstract：:Prostate cancer (PCa) is the most commonly diagnosed cancer in men worldwide. It is essentially dependent on potent androgens, such as testosterone (T) and dihydrotestosterone (DHT). The precursors of T and DHT, which includes androstenedione (A4) and dihydroepiandrosterone (DHEA), and also the metabolites of DHT, 5α-...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Soh SF,Yin X,Sun J,Li J,Yong EL,Wei Q,Gong Y

更新日期：2015-11-10 00:00:00