Control of the illegal use of clenbuterol in bovine production.

abstract：:A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (IS5MN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. T...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Marinković VD,Milojković SS,Nedeljković JM,Comor JJ,Agbaba D,Zivanov-Stakić D

更新日期：1997-11-01 00:00:00

abstract：:Triterpene saponins are important bioactive constituents widely distributed in many plants. Saponins present in Caulophyllum (Berberidaceae) have not been fully characterized. In this study, we studied triterpene saponins from Caulophyllum robustum using liquid chromatography combined with electrospray ionization quad...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Xia YG,Li GY,Liang J,Ortori CA,Yang BY,Kuang HX,Barrett DA

更新日期：2014-11-01 00:00:00

abstract：:Hydrocortisone degradation products 1, 2, 3, and 4 along with hemiacetal derivatives 5, 6, 7, and 8 were observed through stressed hydrocortisone in solution. Their structures were identified based on HPLC-UV, HPLC-MS, and HPLC-HRMS (high resolution/high accuracy mass spectrometry) analyses as well as reaction mechani...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhang F,Zhou J,Shi Y,Tavlarakis P,Karaisz K

更新日期：2016-09-05 00:00:00

abstract：:A new, rapid and simple method is described and applied to resolve and quantify mixtures of prednisolone acetate, sulfacetamide and phenylefrine. The determination was accomplished by micellar electrokinetic capillary chromatography (MEKC) using a fused silica capillary (57 cm x 75 microm ID). The separation was carri...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lemus Gallego JM,Pérez Arroyo J

更新日期：2003-04-01 00:00:00

abstract：:An automated solid-phase extraction workstation was used to develop, characterize and validate two separate HPLC methods for quantifying drugs in plasma. Method development was facilitated by workstation functions which allowed wash solvents of varying organic composition to be mixed and tested automatically. The prec...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Parker TD 3rd,Surendran N,Stewart BH,Rossi DT

更新日期：1998-08-01 00:00:00

abstract：:The recent interest in RX77368 for the treatment of Motor Neurone Disease (MND) has led to the requirement for an assay (RIA) capable of detecting the peptide at low levels in plasma. Several drug conjugates were prepared in which RX77368 was covalently linked to larger proteins, e.g. bovine serum albumin, keyhole lim...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lynn AG,Bennett GW

更新日期：1991-01-01 00:00:00

abstract：:As a vital therapeutic agent for Parkinson's disease, dosage control of levodopa has always been a major obstacle in ensuring efficacy and curbing side effects. Simple and fast electrochemical detection methods are the main force in this field. Here, we presented a differential dual-strip method based on the coulometr...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Yu C,Cao Q,Tu T,Cai Y,Fang L,Ye X,Liang B

更新日期：2020-10-25 00:00:00

abstract：:A common method of assessing the quality of emulsions is to evaluate the size distribution of the globules of the internal phase. The primary aim of this work is to compare the sensitivity of this test to an alternative method. The sizes of the globules of two emulsions, an oral emulsion and a total parenteral nutriti...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Pather SI,Neau SH,Pather S

更新日期：1995-09-01 00:00:00

abstract：:CPZEN-45 is a new drug candidate being considered for the treatment of tuberculosis (TB). The aim of this study was to develop and validate a reverse-phase high-performance liquid chromatographic (HPLC) method suitable to determine CPZEN-45 concentrations in biological samples. CPZEN-45 was extracted from biological f...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hanif SN,Hickey AJ,Garcia-Contreras L

更新日期：2014-01-01 00:00:00

abstract：:A simple, selective and sensitive method has been developed to determine debrisoquine and 4-hydroxydebrisoquine in human urine. Separation of the analytes was obtained using a mobile phase of 0.1 M sodium dihydrogen phosphate-acetonitrile (87:13, v/v) and a muBondapak C18 column. The column effluent was monitored with...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bozkurt A,Basci NE,Isimer A,Kayaalp SO

更新日期：1993-08-01 00:00:00

abstract：:Pogostemon cablin, originating in Malaysia and India, is cultivated in southern China including Guangdong and Hainan Province, which was called GuangHuoXiang to differentiate it from the HuoXiang of the north, the species Agastache rugosa, that it resembles. Essential oil of P. cablin mainly contributes to the pharmac...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hu LF,Li SP,Cao H,Liu JJ,Gao JL,Yang FQ,Wang YT

更新日期：2006-09-18 00:00:00

abstract：:The measurement uncertainty (MU) related to analytical results can lead to false decisions in conformity assessment, such as accepting or rejecting incorrectly a medicine lot (consumer's and producer's risks, respectively). These risks can be global or specific. It is important to understand the different types of con...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Separovic L,Rebello Lourenço F

更新日期：2020-05-30 00:00:00

abstract：:Chinese medicine formula (CMF) usually contains multiple herbs and its components are very complicated, which therapeutic effects are derived from the integrative activity of multiple components. Therefore, the screening of bioactive compounds in the formula is necessary, though it is very difficult, not only for eluc...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Chen L,Chen H,Lu Y,Han L,Wang S,Liu M,Li X,Zhao J,Lu C,Li S

更新日期：2020-07-15 00:00:00

abstract：:A practical HPLC-MS method for the quantitative determination of salacinol (1) and kotalanol (2), potent alpha-glucosidase inhibitors from Salacia species (Hippocrateaceae) as a specific remedy for diabetes in Ayurvedic system, was developed. The optimum conditions of separation and detection of these two constituents...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Muraoka O,Morikawa T,Miyake S,Akaki J,Ninomiya K,Yoshikawa M

更新日期：2010-09-05 00:00:00

abstract：:A selective and sensitive method utilizing gas chromatography-mass spectrometry was developed for simultaneous determination of cinnamaldehyde, cinnamyl alcohol, and methyl cinnamate in rat plasma. Cinnamaldehyde and cinnamyl alcohol can inter-convert to one another in rats, thus simultaneous quantifying both analytes...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhao H,Xie Y,Yang Q,Cao Y,Tu H,Cao W,Wang S

更新日期：2014-02-01 00:00:00

abstract：:Human exposure to aldehydes is implicated in several diseases including cancer. These strong electrophilic compounds can react with nucleophilic sites in DNA to form reversible and irreversible modifications. These modifications, if not repaired, can contribute to pathogenesis. The aim of our study was to provide a ma...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Alamil H,Lechevrel M,Lagadu S,Galanti L,Dagher Z,Delépée R

更新日期：2020-02-05 00:00:00

abstract：:CpG oligodeoxynucleotide 107 (CpG ODN107) could be used as a novel radiosensitizer for glioma. Herein, a novel and sensitive reversed-phase HPLC coupled with electrospray triple quadrupole mass spectrometry (LC-MS/MS) following a one-step C18 solid-phase extraction (SPE) for biological matrix removal was developed and...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Cen Y,Li X,Liu D,Pan F,Cai Y,Li B,Peng W,Wu C,Jiang W,Zhou H

更新日期：2012-11-01 00:00:00

abstract：:A simple, specific and reliable 1H-NMR spectroscopic method for the quantitative determination of the optical purity of indacrinone is described. After conversion of the S(+)- and R(-)-enantiomers to their methyl ester derivatives, they were coordinated with chiral europium(III) or praseodymium(III) shift reagents in ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hanna GM,Lau-Cam CA

更新日期：1989-01-01 00:00:00

abstract：:Spectrophotometric procedures are presented for the determination of two commonly used antidepressant drugs, fluoxetine (I) and sertraline hydrochloride (II). The methods are based mainly on charge transfer complexation reaction of these drugs with either pi acceptors chloranil and 2, 3 dichloro-5, 6-dicyanoquinone (D...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bebawy LI,El-Kousy N,Suddik JK,Shokry M

更新日期：1999-10-01 00:00:00

abstract：:Gamma-hydroxybutyric acid (GHB) and its "pro-drugs", gamma-butyrolactone (GBL) and 1,4 butanediol (1,4-BD), are drugs of abuse with depressant effects on the central nervous system. Many analytical methods have been proposed for the quantitative determination of these compounds mainly in biological matrices but only f...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Rosi L,Frediani P,Bartolucci G

更新日期：2013-02-23 00:00:00

abstract：:This paper describes a method for quantification of d-amphetamine and diphenhydramine in beagle dog plasma by organic solvent field-amplified sample stacking (FASS)-capillary zone electrophoresis (CZE), using amlodipine as the internal standard. The separation was carried out at 25 °C in a 40.2 cm × 75 μm fused-silica...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Li J,Zhang L,Cheng X,Zhang L,Shen B,Qing C,Fan G

更新日期：2018-07-15 00:00:00

abstract：:Homochirality is essential for life. For a long time, it was considered that d-amino acids were excluded from living systems. In the past 30 years, however, d-amino acids have been found in living organisms in the form of free amino acids, peptides and proteins, owing to advances in the analysis of optical isomers of ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Fujii N,Takata T,Fujii N

更新日期：2015-12-10 00:00:00

abstract：:An ion mobility spectrometry (IMS) method was developed to screen for the presence of undeclared synthetic erectile dysfunction (ED) drugs or drug analogues in herbal dietary supplements claiming to enhance male sexual performance. Ion mobility spectra of authenticated reference materials including three FDA approved ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Gryniewicz CM,Reepmeyer JC,Kauffman JF,Buhse LF

更新日期：2009-04-05 00:00:00

abstract：:A method based on capillary zone electrophoresis (CZE) was used to study the interaction between low molecular weight heparin (LMWH) and interleukin 2 (IL-2). The results showed that the increase of the concentration of LMWH led to the decrease of the peak height and the increase of the peak width of IL-2, but the pea...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Liang A,He X,Du Y,Wang K,Fung Y,Lin B

更新日期：2005-07-01 00:00:00

abstract：:Vancomycin (VCN) is an antibiotic used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA)-derived infections. As it has a relatively narrow therapeutic window, it is imperative to develop a sensitive and reliable analytical method for drug monitoring and pharmacokinetic purposes. In the present stu...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Ramadon D,Courtenay AJ,Permana AD,Tekko IA,McAlister E,McCrudden MTC,McCarthy HO,Donnelly RF

更新日期：2020-09-10 00:00:00

abstract：:Omega-3 fatty acids are clinically useful and the two marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are prevalent in fish and fish oils. Omega-3 fatty acid formulations should undergo a rigorous regulatory step in order to obtain United States Food and Drug Administration (USFDA...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Viswanathan S,Verma PRP,Ganesan M,Manivannan J

更新日期：2017-07-15 00:00:00

abstract：:The resolution of four racemic 3-hydroxy-1,4-benzodiazepin-2-ones, widely used in therapeutics, by means of a chiral stationary phase is described. The chiral selector used is (S)-N-(3,5-dinitrobenzoyl)phenylalanine. This chiral stationary phase showed both good enantioselectivity and efficiency for the compounds. Elu...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Oliveros L,Minguillon C,Billaud C

更新日期：1992-10-01 00:00:00

abstract：:Phytosterols are bioactive compounds, one of their most studied and outstanding properties being their cholesterol-lowering activity. This explains the growing interest in the phytosterol contents of foods as either intrinsic or added components. The different steps (extraction, saponification, clean up, chromatograph...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lagarda MJ,García-Llatas G,Farré R

更新日期：2006-08-28 00:00:00

abstract：:A selective and sensitive liquid chromatography-mass spectrometry (LC-MS) method was developed for the simultaneous determination of Euphorbia factor L(1), Euphorbia factor L(2) and Euphorbia factor L(3) from Euphorbiae semen in rat plasma. Larotaxel was added to a 200 μL plasma sample as the internal standard (IS). T...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Meng X,Zhao X,Long Z,Yuan Y,Zhuang H,Bi K,Chen X

更新日期：2013-01-01 00:00:00

abstract：:Management of the therapy of life-threatening bacterial infection is extremely based on an optimal antibiotic treatment. Achieving the correct vancomycin dosage in blood and target tissues can be complicated in special situations, e.g., where large fluid sequestration and/or acute renal failure occur. A UHPLC-MS/MS me...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Javorska L,Krcmova LK,Solich P,Kaska M

更新日期：2017-08-05 00:00:00