Gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations.

Abstract:

:A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (IS5MN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 micrograms in dosage formulations for IS5MN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of IS5MN.

journal_name

J Pharm Biomed Anal

authors

Marinković VD,Milojković SS,Nedeljković JM,Comor JJ,Agbaba D,Zivanov-Stakić D

doi

10.1016/s0731-7085(97)00079-4

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

425-9

issue

3

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(97)00079-4

journal_volume

16

pub_type

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