Abstract:
:A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (IS5MN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 micrograms in dosage formulations for IS5MN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of IS5MN.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Marinković VD,Milojković SS,Nedeljković JM,Comor JJ,Agbaba D,Zivanov-Stakić Ddoi
10.1016/s0731-7085(97)00079-4subject
Has Abstractpub_date
1997-11-01 00:00:00pages
425-9issue
3eissn
0731-7085issn
1873-264Xpii
S0731-7085(97)00079-4journal_volume
16pub_type
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