Abstract:
:The electrochemical oxidation of azithromycin was investigated in order to elucidate the mechanism for possible oxidative metabolic pathways in humans. Electrochemical studies were carried out by cyclic voltammetry and preparative scale electrolysis at glassy carbon electrodes. It was found that azithromycin undergoes anodic oxidation at one or both amine groups with the rapid follow-up chemistry of intermediate radical cation. Main products of the oxidation were determined by HPLC analysis and were identified as a protonated azithromycin and products obtained by demethylation of the 3'-dimethylamino or macrolactone amino group.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Mandić Z,Weitner Z,Ilijas Mdoi
10.1016/s0731-7085(03)00315-7subject
Has Abstractpub_date
2003-11-24 00:00:00pages
647-54issue
4eissn
0731-7085issn
1873-264Xpii
S0731708503003157journal_volume
33pub_type
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