Abstract:
:In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single test system which would be suitable for release testing of such complex dosage forms. This article is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Jug M,Hafner A,Lovrić J,Kregar ML,Pepić I,Vanić Ž,Cetina-Čižmek B,Filipović-Grčić Jdoi
10.1016/j.jpba.2017.06.072subject
Has Abstractpub_date
2018-01-05 00:00:00pages
350-366eissn
0731-7085issn
1873-264Xpii
S0731-7085(17)31210-4journal_volume
147pub_type
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