Abstract:
:Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely diagnosis and accurate monitoring of disease are decisive to improve the accuracy of therapy. In the present work, we present a NMR-based metabolomic study of blood sera of APS patients. Our data show that individuals suffering APS have a characteristic metabolomic profile with abnormalities associated to the metabolism of methyl group donors, ketone bodies and amino acids. We have identified for the first time the metabolomic fingerprint characterizing APS disease having potential application to improve APS timely diagnosis and appropriate therapeutic approaches.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Palisi A,Grimaldi M,Sabatini P,Montoro P,Scrima M,Rodriquez M,D'Ursi AMdoi
10.1016/j.jpba.2016.11.002subject
Has Abstractpub_date
2017-01-30 00:00:00pages
90-95eissn
0731-7085issn
1873-264Xpii
S0731-7085(16)31018-4journal_volume
133pub_type
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