Abstract:
:The interactions between a nonsteroidal anti-inflammatory drugs, oxyphenbutazone (OPB), with two cyclodextrins, beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), have been studied in an aqueous medium and in the solid state. Differential scanning calorimetry, hot stage microscopy, thermogravimetric analysis and X-ray diffraction (XRD) powder have been the techniques used to characterize the interactions in the solid state. Although OPB forms inclusion compounds with beta- and gamma-CD in the aqueous medium, only the OPB/gamma-CD inclusion compound was obtained in the solid state by the kneading method. The XRD powder used at different temperatures has proven be a useful tool in characterizing the behaviour of these binary systems.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Veiga MD,Merino Mdoi
10.1016/s0731-7085(02)00042-0subject
Has Abstractpub_date
2002-06-01 00:00:00pages
973-82issue
5eissn
0731-7085issn
1873-264Xpii
S0731708502000420journal_volume
28pub_type
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