SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease.

abstract：PURPOSE:The expression of chemokine receptor type 4 (CXCR4) was found co-localized with macrophages on the atherosclerotic vessel wall and participated in the initial emigration of leukocytes. Gallium-68 [68Ga]Pentixafor has recently been introduced for the imaging of atherosclerosis by targeting CXCR4. We sought to ev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Li X,Heber D,Leike T,Beitzke D,Lu X,Zhang X,Wei Y,Mitterhauser M,Wadsak W,Kropf S,Wester HJ,Loewe C,Hacker M,Haug AR

更新日期：2018-04-01 00:00:00

abstract：:Assessing joint disorders has been a relatively recent and evolving application of 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) imaging. FDG is taken up by inflammatory cells, particularly when they are active as part of an ongoing inflammatory process. Hence FDG PET has been employed to ass...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Carey K,Saboury B,Basu S,Brothers A,Ogdie A,Werner T,Torigian DA,Alavi A

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Although two norepinephrine transporter (NET) radioligands, (S,S)-[(18)F]FMeNER-D(2) and (S,S)-[(11)C]MeNER, have been reported to have different characteristics, there has not been a direct comparative study in vivo. METHODS:In this preliminary study, two rhesus monkeys underwent three PET measurements each, ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Takano A,Gulyás B,Varrone A,Halldin C

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To evaluate the diagnostic potential of PET/MRI with [(18)F]FDG in recurrent ovarian and cervical cancer in comparison to PET/CT. METHODS:A group of 19 patients with suspected recurrence of pelvic malignancies (ovarian cancer, 11 patients; cervical cancer, 8 patients) scheduled for an [(18)F]FDG PET/CT were su...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Beiderwellen K,Grueneisen J,Ruhlmann V,Buderath P,Aktas B,Heusch P,Kraff O,Forsting M,Lauenstein TC,Umutlu L

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Vascular prosthesis infection (VPI) is a life-threatening complication that occurs in 0.5-5% of prostheses. Low-grade infections in non-acute patients are a diagnostic challenge requiring a new method with good diagnostic accuracy. The aim of this work was to define the accuracy of (18)F-FDG PET/CT in thes...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Spacek M,Belohlavek O,Votrubova J,Sebesta P,Stadler P

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Previous functional neuroimaging studies suggest that selective aspects of the brain serotonin (5-HT) system change during the aging process. Here, we assessed the effects of aging on the brain regional alpha-[(11)C]methyl-L: -tryptophan (alpha-[(11)C]MTrp) trapping rate constant (K*; microl.g(-1).min(-1)), whi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rosa-Neto P,Benkelfat C,Sakai Y,Leyton M,Morais JA,Diksic M

更新日期：2007-08-01 00:00:00

abstract：:[Yttrium-90-DOTA-Tyr(3)]-octreotide (DOTATOC) and [(177)Lu-DOTA-Tyr(3)-Thr(8)]-octreotide (DOTATATE) are used for peptide receptor-mediated radionuclide therapy (PRMRT) in neuroendocrine tumours. No human data comparing these two compounds are available so far. We used (111)In as a surrogate for (90)Y and (177)Lu and ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Forrer F,Uusijärvi H,Waldherr C,Cremonesi M,Bernhardt P,Mueller-Brand J,Maecke HR

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:According to the updated WHO classification of gliomas with its emphasis on molecular parameters, tumours with an IDH-wildtype status have a dismal prognosis. To ensure timely adjustment of treatment, demand for non-invasive prediction methods is high. 18F-FET PET has been shown to be an important diagnostic to...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Vettermann F,Suchorska B,Unterrainer M,Nelwan D,Forbrig R,Ruf V,Wenter V,Kreth FW,Herms J,Bartenstein P,Tonn JC,Albert NL

更新日期：2019-11-01 00:00:00

abstract：:The evaluation of myocardial glucose utilisation with fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography is currently considered the most reliable tool for the identification of myocardial viability. However, the investigations using FDG imaging to predict improvement in left ventricular (LV) functi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Knuuti J,Schelbert HR,Bax JJ

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:No data are yet available in the literature concerning 3-D [(123)I]-meta-iodobenzylguanidine ([(123)I]-MIBG) kinetics in vivo. In this study we investigated the feasibility of dynamic 3-D [(123)I]-MIBG kinetic analysis using a CZT ultrafast camera. METHODS:The study group comprised 16 patients consecutively sc...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tinti E,Positano V,Giorgetti A,Marzullo P

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the differential uptake of O-(2-[18F]fluorethyl)-L-tyrosine (FET) in suspected primary brain tumours. METHODS:Positron emission tomography (PET) was performed in 44 patients referred for the evaluation of a suspected brain tumour. Acquisition consisted of four 10-min frame...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Weckesser M,Langen KJ,Rickert CH,Kloska S,Straeter R,Hamacher K,Kurlemann G,Wassmann H,Coenen HH,Schober O

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:The quantitative imaging features (radiomics) that can be obtained from the different modalities of current-generation hybrid imaging can give complementary information with regard to the tumour environment, as they measure different morphologic and functional imaging properties. These multi-parametric ima...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Castiglioni I,Gallivanone F,Soda P,Avanzo M,Stancanello J,Aiello M,Interlenghi M,Salvatore M

更新日期：2019-12-01 00:00:00

abstract：:The biodistribution of radioactivity after the administration of a new tracer for alpha4beta2 nicotinic acetylcholine receptors (nAChRs), [123I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine (5-I-A-85380), was studied in ten healthy human subjects. Following administration of 98+/-6 MBq [123I]5-I-A-85380, serial whole-bo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Fujita M,Seibyl JP,Vaupel DB,Tamagnan G,Early M,Zoghbi SS,Baldwin RM,Horti AG,KoreN AO,Mukhin AG,Khan S,Bozkurt A,Kimes AS,London ED,Innis RB

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:Although polyphosphonates (PPs) were introduced as bone imaging agents in nuclear medicine in the early 1970s, the mechanisms involved in their uptake still remain unclear. Suggested mechanisms range from mineral adsorption with disputed binding to the organic phase, over incorporation into the mineralisation p...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Toegel S,Hoffmann O,Wadsak W,Ettlinger D,Mien LK,Wiesner K,Nguemo J,Viernstein H,Kletter K,Dudczak R,Mitterhauser M

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:We previously reported in a small series of patients that (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) scintigraphy tested positive in transthyretin-related (TTR) (both mutant and wild-type) but not in primary (AL) amyloidotic cardiomyopathy (AC). We extended our study to a larger cohort o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Rapezzi C,Quarta CC,Guidalotti PL,Longhi S,Pettinato C,Leone O,Ferlini A,Salvi F,Gallo P,Gagliardi C,Branzi A

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:PET is a powerful tool for assessing targeted therapy. Since (18)F-FDG shows a potential prognostic value in medullary thyroid carcinoma (MTC), this study evaluated (18)F-FDG PET alone and combined with morphological and biomarker evaluations as a surrogate marker of overall survival (OS) in patients with progr...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Salaun PY,Campion L,Ansquer C,Frampas E,Mathieu C,Robin P,Bournaud C,Vuillez JP,Taieb D,Rousseau C,Drui D,Mirallié E,Borson-Chazot F,Goldenberg DM,Chatal JF,Barbet J,Kraeber-Bodéré F

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Multiple myeloma (MM) is a bone marrow malignancy that remains mostly incurable. Elotuzumab is an FDA-approved therapeutic monoclonal antibody targeted to the cell surface glycoprotein CS1, which is overexpressed in MM cells. Identifying patients who will respond to CS1-targeted treatments such as elotuzumab re...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ghai A,Zheleznyak A,Mixdorf M,O'Neal J,Ritchey J,Rettig M,DiPersio J,Shokeen M,Achilefu S

更新日期：2020-11-11 00:00:00

abstract：PURPOSE:An effective pretargeting strategy was developed for renal cell carcinoma (RCC) based on a biologically produced bispecific monoclonal antibody: anti-RCCxanti-DTPA(In) (bsMAb: G250xDTIn-1). Tumour uptake of a (111)In-labelled bivalent peptide after pretargeting with bsMAb G250xDTIn-1 was relatively high compare...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Schaijk FG,Boerman OC,Soede AC,McBride WJ,Goldenberg DM,Corstens FH,Oosterwijk E

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is commonly accepted as the gold standard to assess outcome after NAC in breast cancer patients. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) has unique value in tumor staging, predicting prognosis, and eval...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Li P,Wang X,Xu C,Liu C,Zheng C,Fulham MJ,Feng D,Wang L,Song S,Huang G

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:Twelve years ago a meta-analysis evaluated the diagnostic performance of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in assessing musculoskeletal soft tissue lesions (MsSTL). Currently, PET/CT has substituted PET imaging; however, there has not been any published meta-analysis on the use o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Etchebehere EC,Hobbs BP,Milton DR,Malawi O,Patel S,Benjamin RS,Macapinlac HA

更新日期：2016-05-01 00:00:00

abstract：:The aims of this study were to assess the potential of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) for tumor grading in chondrosarcoma patients and to evaluate the role of standardized uptake value (SUV) as a parameter for prediction of patient outcome. FDG PET imaging was performed in 31 pat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brenner W,Conrad EU,Eary JF

更新日期：2004-02-01 00:00:00

abstract：:This review presents neuroimaging studies which have explored the functional anatomy of a variety of cognitive processes represented by the prefrontal cortex (PFC). Overall, these studies have demonstrated that standard prefrontal neuroactivation tasks recruit a widely distributed network within the brain of which the...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Goethals I,Audenaert K,Van de Wiele C,Dierckx R

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:To characterise tissue sites of immune activation and HIV replication we performed FDG-PET in ART-treated and ART-naive HIV-infected individuals. Specific aims were to establish whether HIV-infected patients can be differentiated on the basis of the detection of specific locations of viral replication, even in ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lucignani G,Orunesu E,Cesari M,Marzo K,Pacei M,Bechi G,Gori A,Gaito S,Clerici M,Chiti A

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Although [(18)F]FDG PET can measure therapy response sooner and more accurately than morphological imaging techniques, there is still some debate as to whether [(18)F]FDG uptake really reflects changes in the viable cell fraction. In this study changes in [(18)F]FDG uptake were investigated in a lymphoma model ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brepoels L,De Saint-Hubert M,Stroobants S,Verhoef G,Balzarini J,Mortelmans L,Mottaghy FM

更新日期：2010-08-01 00:00:00

abstract：:Nuclear medicine has a central role in the diagnosis, staging, response assessment and long-term follow-up of neuroblastoma, the most common solid extracranial tumour in children. These EANM guidelines include updated information on 123I-mIBG, the most common study in nuclear medicine for the evaluation of neuroblasto...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bar-Sever Z,Biassoni L,Shulkin B,Kong G,Hofman MS,Lopci E,Manea I,Koziorowski J,Castellani R,Boubaker A,Lambert B,Pfluger T,Nadel H,Sharp S,Giammarile F

更新日期：2018-10-01 00:00:00

abstract：RATIONALE:In Parkinson's disease (PD), spatial covariance analysis of 18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a f...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Meles SK,Renken RJ,Pagani M,Teune LK,Arnaldi D,Morbelli S,Nobili F,van Laar T,Obeso JA,Rodríguez-Oroz MC,Leenders KL

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:The histamine H3 receptors are presynaptic neuroreceptors that inhibit the release of histamine and other neurotransmitters. The receptors are considered a drug target for sleep disorders and neuropsychiatric disorders with cognitive decline. We developed a novel PET ligand for the H3 receptors, [(11)C]TASP0410...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kimura Y,Seki C,Ikoma Y,Ichise M,Kawamura K,Takahata K,Moriguchi S,Nagashima T,Ishii T,Kitamura S,Niwa F,Endo H,Yamada M,Higuchi M,Zhang MR,Suhara T

更新日期：2016-08-01 00:00:00

abstract：:Oxygen (O(2)) inhalation after acute myocardial ischaemia has long been a part of standard therapy in cardiology. It has also been demonstrated that therapeutic hyperoxia diminishes myocardial stunning. The aim of this pilot study was to investigate whether the uptake kinetics of the myocardial perfusion agent technet...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Basoglu T,Yapici O,Aksakal E,Sahin M,Canbaz F,Albayrak S,Yesildag O

更新日期：2002-11-01 00:00:00

abstract：:In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss. Since the advent of the first Aβ-specific positron emission tomography (PET) ligand, (11)C-Pittsburgh compound B ([...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Heurling K,Leuzy A,Zimmer ER,Lubberink M,Nordberg A

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Lipid nanocapsules (LNC) entrapping lipophilic complexes of (188)Re ((188)Re(S(3)CPh)(2)(S(2)CPh) [(188)Re-SSS]) were investigated as a novel radiopharmaceutical carrier for internal radiation therapy of malignant gliomas. The present study was designed to evaluate the efficacy of intra-cerebral administration ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Allard E,Hindre F,Passirani C,Lemaire L,Lepareur N,Noiret N,Menei P,Benoit JP

更新日期：2008-10-01 00:00:00