Abstract：
PURPOSE:Previous functional neuroimaging studies suggest that selective aspects of the brain serotonin (5-HT) system change during the aging process. Here, we assessed the effects of aging on the brain regional alpha-[(11)C]methyl-L: -tryptophan (alpha-[(11)C]MTrp) trapping rate constant (K*; microl.g(-1).min(-1)), which, with certain assumptions, could be taken as a proxy of 5-HT synthesis. METHODS:Thirty-six healthy right-handed subjects had positron emission tomography (PET) scans following injection with alpha-[(11)C]MTrp [18 males aged 46.6 +/- 22.2 years (range 20-80 years) and 18 females aged 33.0 +/- 15.5 years (range 20-80 years)]. The trapping rate constant, K*, was calculated with the graphical method for irreversible ligands using the sinus-venous input function. A priori selected volumes of interest (VOIs) were defined using an automatic algorithm. RESULTS:VOI analysis showed no correlation between age and brain regional K* values. As reported by others, significant age-related reductions of gray matter were observed in the thalamus and frontal and cingulate cortices; even with partial volume correction there was still no significant relationship between K* and age. Further exploratory SPM voxelwise correlation between age and alpha-[(11)C]MTrp trapping, using p = 0.05 (uncorrected), as well as voxel-based morphometry, was in agreement with the VOI analysis. CONCLUSION:The dissociation between age-related changes in brain anatomy and this index of serotonin synthesis suggests independent mechanisms underlying the normal aging process.
journal_name
Eur J Nucl Med Mol Imagingauthors
Rosa-Neto P,Benkelfat C,Sakai Y,Leyton M,Morais JA,Diksic Mdoi
10.1007/s00259-007-0365-xsubject
Has Abstractpub_date
2007-08-01 00:00:00pages
1254-64issue
8eissn
1619-7070issn
1619-7089journal_volume
34pub_type
杂志文章abstract：PURPOSE:The serotonin-1A (5-HT(1A)) receptor is implicated in the pathophysiology of major neuropsychiatric disorders. Thus, the functional imaging of 5-HT(1A) receptors by positron emission tomography (PET) may contribute to the understanding of its role in those pathologies and their therapeutics. These receptors exi...
journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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abstract：PURPOSE:This study was conducted to investigate whether( 18)F-fluorodeoxyglucose (FDG) uptake, quantified by positron emission tomography (PET), correlates with histological variables including tumour grade, cell proliferation, cell cycle control integrity and glucose metabolism in patients with bone and soft tissue sa...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,评审
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-005-1955-0
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
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更新日期：2014-08-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-009-1207-9
更新日期：2009-12-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-011-1876-z
更新日期：2011-10-01 00:00:00
