AI-based applications in hybrid imaging: how to build smart and truly multi-parametric decision models for radiomics.

abstract：PURPOSE:To evaluate, in patients with chest pain, the diagnostic value of ST elevation (STE) in lead aVR during stress testing prior to (99m) Tc-sestamibi scanning correlating ischaemic territory with angiographic findings. METHODS:Consecutive patients attending for (99m) Tc-sestamibi myocardial perfusion imaging (MPI...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Neill J,Shannon HJ,Morton A,Muir AR,Harbinson M,Adgey JA

更新日期：2007-03-01 00:00:00

abstract：:The human cardiac nervous system consists of a sympathetic and a parasympathetic branch with (-)-norepinephrine and acetylcholine as the respective endogenous neurotransmitters. Dysfunction of the cardiac nervous system is implicated in various types of cardiac disease, such as heart failure, myocardial infarction and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Langer O,Halldin C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Extracapsular spread (ECS) to the cervical lymph nodes is a major adverse prognostic factor in oral cavity squamous cell carcinoma (OSCC). We prospectively examined the value of FDG PET immediately before postoperative radiotherapy/concurrent chemoradiotherapy (pre-RT/CCRT PET) to detect residual/relapsing dise...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Liao CT,Fan KH,Lin CY,Wang HM,Huang SF,Chen IH,Kang CJ,Ng SH,Hsueh C,Lee LY,Lin CH,Yen TC

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Rhenium-188-HEDP is a beta-emitting radiopharmaceutical used for palliation of metastatic bone pain. We investigated whether the addition of rhenium-188-HEDP to docetaxel/prednisone improved efficacy of chemotherapy in patients with CRPC. METHODS:Patients with progressive CRPC and osteoblastic bone metastas...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Dodewaard-de Jong JM,de Klerk JMH,Bloemendal HJ,Oprea-Lager DE,Hoekstra OS,van den Berg HP,Los M,Beeker A,Jonker MA,O'Sullivan JM,Verheul HMW,van den Eertwegh AJM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Right ventricular (RV) performance is known to have prognostic value in patients with congestive heart failure (CHF). Cardiac resynchronization therapy (CRT) has been found to enhance left ventricular (LV) energetics and metabolic reserve in patients with heart failure. The interplay between the LV and RV may p...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Knuuti J,Sundell J,Naum A,Engblom E,Koistinen J,Ylitalo A,Stolen KQ,Kalliokoski R,Nekolla SG,Bax KE,Airaksinen KE

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Percutaneous transluminal coronary angioplasty (PTCA) is one of the main therapy options for patients with coronary artery disease (CAD), resulting in an improvement in myocardial perfusion and exercise capacity. Nevertheless, studies have also demonstrated a positive effect of regular exercise training on myoc...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kendziorra K,Walther C,Foerster M,Möbius-Winkler S,Conradi K,Schuler G,Sabri O,Hambrecht R,Kluge R

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to map treatment-induced (99m)Tc-Hynic-rh-annexin V uptake in normal tissues using co-registration of SPECT and CT. METHODS:Nineteen patients (11 male, 8 female, mean age 57 years) with various malignant tumours (12 lymphomas, four non-small cell lung cancers and three head and ne...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kartachova MS,Valdés Olmos RA,Haas RL,Hoebers FJ,van den Brekel MW,van Zandwijk N,Herk Mv,Verheij M

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:We report the biodistribution and radiation dosimetry of an integrin αvβ3 specific PET tracer (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2) (denoted as (18)F-Alfatide II). We also assessed the value of (18)F-Alfatide II in patients with brain metastases. METHODS:A series of torso (from the skull to the thigh) static image...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yu C,Pan D,Mi B,Xu Y,Lang L,Niu G,Yang M,Wan W,Chen X

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To determine whether [18F]FDG PET/CT-derived radiomic features alone or in combination with clinical, laboratory and biological parameters are predictive of 2-year progression-free survival (PFS) in patients with mantle cell lymphoma (MCL), and whether they enable outcome prognostication. METHODS:Included in t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Mayerhoefer ME,Riedl CC,Kumar A,Gibbs P,Weber M,Tal I,Schilksy J,Schöder H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Diagnosis of spondylodiscitis (SD) may be challenging due to the nonspecific clinical and laboratory findings and the need to perform various diagnostic tests including serologic, imaging, and microbiological examinations. Homogeneous management of SD diagnosis through international, multidisciplinary guidance ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lazzeri E,Bozzao A,Cataldo MA,Petrosillo N,Manfrè L,Trampuz A,Signore A,Muto M

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Several patients experience unexplained persistent symptoms after SARS-CoV-2 recovering. We aimed at evaluating if 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was able to demonstrate a persistent inflammatory process. METHODS:Recovered adult COVID-19 patients, who complained unexplained persisting symptoms for ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sollini M,Ciccarelli M,Cecconi M,Aghemo A,Morelli P,Gelardi F,Chiti A

更新日期：2020-10-30 00:00:00

abstract：PURPOSE:(32)P-chromic phosphate colloid treatments of astrocytoma and craniopharyngioma cystic brain tumours in paediatric patients are conventionally based on a sphere model under the assumption of uniform uptake. The aims of this study were to determine the distribution of the absorbed dose delivered by (32)P on a pa...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Denis-Bacelar AM,Romanchikova M,Chittenden S,Saran FH,Mandeville H,Du Y,Flux GD

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:The nucleoside analogue 3'-deoxy-3'-(18)F-fluorothymidine (FLT) has recently been introduced for imaging cell proliferation with positron emission tomography (PET). We prospectively evaluated whether FLT uptake reflects proliferative activity as indicated by the Ki-67 index in non-small cell lung cancer (NSCLC)...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yamamoto Y,Nishiyama Y,Ishikawa S,Nakano J,Chang SS,Bandoh S,Kanaji N,Haba R,Kushida Y,Ohkawa M

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the impact of [18F]fluorodeoxy-D-glucose positron emission tomography (FDG-PET) on the primary staging of patients with small-cell lung cancer (SCLC). METHODS:FDG-PET was performed in 120 consecutive patients with SCLC during primary staging. In addition, brain examina...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brink I,Schumacher T,Mix M,Ruhland S,Stoelben E,Digel W,Henke M,Ghanem N,Moser E,Nitzsche EU

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:In recent decades, the use of radiopharmaceuticals in the assessment of hepatocellular carcinoma (HCC) has become established, and new findings indicate that radiolabelled choline has considerable potential in this setting. Therefore, in this study we aimed to assess the diagnostic role of (11)C-choline positro...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lopci E,Torzilli G,Poretti D,de Neto LJ,Donadon M,Rimassa L,Lanza E,Sabongi JG,Ceriani R,Personeni N,Palmisano A,Pedicini V,Comito T,Scorsetti M,Chiti A

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) imaging of serotonin 2A (5-HT(2A)) receptors with agonist tracers holds promise for the selective labelling of 5-HT(2A) receptors in their high-affinity state. We have previously validated [(11)C]Cimbi-5 and found that it is a 5-HT(2A) receptor agonist PET tracer. In an attemp...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ettrup A,Hansen M,Santini MA,Paine J,Gillings N,Palner M,Lehel S,Herth MM,Madsen J,Kristensen J,Begtrup M,Knudsen GM

更新日期：2011-04-01 00:00:00

abstract：:Flow quantitation with nitrogen-13 ammonia ((13)NH(3)) and positron emission tomography (PET) is dependent on an accurate blood time-activity curve. This is conveniently derived from the PET images by drawing a region of interest in the left ventricular cavity. The blood time-activity curve obtained in this way, howev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hove JD,Iida H,Kofoed KF,Freiberg J,Holm S,Kelbaek H

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Firefly luciferase catalyzes the oxidative decarboxylation of D: -luciferin to oxyluciferin in the presence of cofactors, producing bioluminescence. This reaction is used in optical bioluminescence-based molecular imaging approaches to detect the expression of the firefly luciferase reporter gene. Biokinetics a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Berger F,Paulmurugan R,Bhaumik S,Gambhir SS

更新日期：2008-12-01 00:00:00

abstract：:Radioiodine therapy is now the most common definite treatment for persistent hyperthyroidism. The outcome of radioiodine therapy depends mainly on the absorbed energy dose in the diseased thyroid tissue. The administered activity and the resulting target dose in the thyroid depend on both the biokinetics of radioiodin...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Moka D,Dietlein M,Schicha H

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:In a minority of cases a definite diagnosis and stage grouping in cancer patients is not possible based on the imaging information of PET/CT. We report our experience with percutaneous PET/CT-guided bone biopsies to histologically verify the aetiology of hypermetabolic bone lesions. METHODS:We retrospectively ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Klaeser B,Wiskirchen J,Wartenberg J,Weitzel T,Schmid RA,Mueller MD,Krause T

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the differential uptake of O-(2-[18F]fluorethyl)-L-tyrosine (FET) in suspected primary brain tumours. METHODS:Positron emission tomography (PET) was performed in 44 patients referred for the evaluation of a suspected brain tumour. Acquisition consisted of four 10-min frame...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Weckesser M,Langen KJ,Rickert CH,Kloska S,Straeter R,Hamacher K,Kurlemann G,Wassmann H,Coenen HH,Schober O

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yakushev I,Schreckenberger M,Müller MJ,Schermuly I,Cumming P,Stoeter P,Gerhard A,Fellgiebel A

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:To analyse the diagnostic value of (18)F-FDG PET and MRI for the evaluation of active lesions in paediatric Langerhans cell histiocytosis. METHODS:We compared 21 (18)F-FDG PET scans with 21 MRI scans (mean time interval 17 days) in 15 patients (11 male, 4 female, age range 4 months to 19 years) with biopsy-pro...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Mueller WP,Melzer HI,Schmid I,Coppenrath E,Bartenstein P,Pfluger T

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To assess the role of single-photon emission computed tomography with computed tomography (SPECT-CT) for the identification of sentinel lymph nodes (SLNs) in patients with early stage (T1-T2) oral cancer and a clinically negative neck (cN0). METHODS:In addition to planar lymphoscintigraphy, SPECT-CT was perfor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： den Toom IJ,van Schie A,van Weert S,Karagozoglu KH,Bloemena E,Hoekstra OS,de Bree R

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to play an important role in resistance to central nervous system drug treatment. (R)-[(11)C]verapamil (VPM) PET can be used to measure the function of P-gp at the BBB, but low brain uptake of VPM...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kuntner C,Bankstahl JP,Bankstahl M,Stanek J,Wanek T,Stundner G,Karch R,Brauner R,Meier M,Ding X,Müller M,Löscher W,Langer O

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Investigate whether 18F-FDG PET-CT has the potential to predict the major pathologic response (MPR) to neoadjuvant sintilimab in resectable NSCLC patients, and the potential of sifting patients who probably benefit from immunotherapy. METHODS:Treatment-naive patients with resectable NSCLC (stage IA-IIIB) recei...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tao X,Li N,Wu N,He J,Ying J,Gao S,Wang S,Wang J,Wang Z,Ling Y,Tang W,Zhang Z

更新日期：2020-05-01 00:00:00

abstract：UNLABELLED:There are specific dose recommendations for diagnostic amyloid PET imaging with 18F-florbetapir, but they may not apply to research studies using regional quantitative analysis. We, therefore, studied the effect of tracer dose reduction on the discriminative power of regional analysis. METHODS:Using bootstr...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Herholz K,Evans R,Anton-Rodriguez J,Hinz R,Matthews JC

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:Radiolabelled somatostatin (SST) analogues have proven useful in diagnosing tumours positive for SST receptor (SSTR). As different subtypes of SSTR are expressed on the tumour cell surface, the choice of appropriate therapeutic SST analogue is crucial. We evaluated the SSTR status of thyroid cancer patients who...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Traub-Weidinger T,Putzer D,von Guggenberg E,Dobrozemsky G,Nilica B,Kendler D,Bale R,Virgolini IJ

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Left ventricular (LV) mechanical dyssynchrony (LVMD) was assessed by gated single-photon emission CT myocardial perfusion imaging (MPI) as an independent predictor of death from any cause in patients with known coronary artery disease (CAD) and reduced LV function. METHODS:Between 2001 and 2010, 135 patients (...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Uebleis C,Hellweger S,Laubender RP,Becker A,Sohn HY,Lehner S,Haug A,Bartenstein P,Cumming P,Van Kriekinge SD,Slomka PJ,Hacker M

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:The precise clinical utility of lung 201Tl uptake in exercise SPECT myocardial perfusion imaging remains open to research. This study validates an optimal index for lung 201Tl uptake measurement and assesses its value in the prediction of higher-risk coronary artery disease (CAD). METHOD:Three hundred and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Moralidis E,Spyridonidis T,Arsos G,Anagnostopoulos C

更新日期：2007-04-01 00:00:00