Sex differences in leucocyte telomere length in a free-living mammal.

Abstract:

:Mounting evidence suggests that average telomere length reflects previous stress and predicts subsequent survival across vertebrate species. In humans, leucocyte telomere length (LTL) is consistently shorter during adulthood in males than in females, although the causes of this sex difference and its generality to other mammals remain unknown. Here, we measured LTL in a cross-sectional sample of free-living Soay sheep and found shorter telomeres in males than in females in later adulthood (>3 years of age), but not in early life. This observation was not related to sex differences in growth or parasite burden, but we did find evidence for reduced LTL associated with increased horn growth in early life in males. Variation in LTL was independent of variation in the proportions of different leucocyte cell types, which are known to differ in telomere length. Our results provide the first evidence of sex differences in LTL from a wild mammal, but longitudinal studies are now required to determine whether telomere attrition rates or selective disappearance are responsible for these observed differences.

journal_name

Mol Ecol

journal_title

Molecular ecology

authors

Watson RL,Bird EJ,Underwood S,Wilbourn RV,Fairlie J,Watt K,Salvo-Chirnside E,Pilkington JG,Pemberton JM,McNeilly TN,Froy H,Nussey DH

doi

10.1111/mec.13992

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

3230-3240

issue

12

eissn

0962-1083

issn

1365-294X

journal_volume

26

pub_type

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