MHC diversity and the association to nematode parasitism in the yellow-necked mouse (Apodemus flavicollis).


:In vertebrates, the genes of the major histocompatibility complex (MHC) are among the most debated candidates accounting for co-evolutionary processes of host-parasite interaction at the molecular level. The exceptionally high allelic polymorphism found in MHC loci is believed to be maintained by pathogen-driven selection, mediated either through heterozygous advantage or rare allele advantage (= frequency dependent selection). While investigations under natural conditions are still very rare, studies on humans or mice under laboratory conditions revealed support for both hypotheses. We investigated nematode burden and allelic diversity of a functional important MHC class II gene (DRB exon2) in free-ranging yellow-necked mice (Apodemus flavicollis). Twenty-seven distinct Apfl-DRB alleles were detected in 146 individuals with high levels of amino acid sequence divergence, especially at the antigen binding sites (ABS), indicating selection processes acting on this locus. Heterozygosity had no influence on the infection status (being infected or not), the number of different nematode infections (NNI) or the intensity of infection, measured as the individual faecal egg count (FEC). However, significant associations of specific Apfl-DRB alleles to both nematode susceptibility and resistance were found, for all nematodes as well as in separate analyses of the two most common nematodes. Apodemus flavicollis individuals carrying the alleles Apfl-DRB*5 or Apfl-DRB*15 revealed significantly higher FEC than individuals with other alleles. In contrast, the allele Apfl-DRB*23 showed a significant association to low FEC of the most common nematode. Thus, our results provide evidence for pathogen-driven selection acting through rare allele advantage under natural conditions.


Mol Ecol


Molecular ecology


Meyer-Lucht Y,Sommer S




Has Abstract


2005-06-01 00:00:00














  • Refugia of Potentilla matsumurae (Rosaceae) located at high mountains in the Japanese archipelago.

    abstract::Molecular phylogeographic studies have revealed the genetic patterns and glacial-interglacial history of many plant and animal species. To infer the Quaternary history of alpine plants in the Japanese archipelago, which is poorly known, we investigated 203 individuals of Potentilla matsumurae and its varieties from 22...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Ikeda H,Senni K,Fujii N,Setoguchi H

    更新日期:2006-10-01 00:00:00

  • Spatial patterning of soil microbial communities created by fungus-farming termites.

    abstract::Spatially overdispersed mounds of fungus-farming termites (Macrotermitinae) are hotspots of nutrient availability and primary productivity in tropical savannas, creating spatial heterogeneity in communities and ecosystem functions. These termites influence the local availability of nutrients in part by redistributing ...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Baker CCM,Castillo Vardaro JA,Doak DF,Pansu J,Puissant J,Pringle RM,Tarnita CE

    更新日期:2020-11-01 00:00:00

  • Heterologous hybridization to a complementary DNA microarray reveals the effect of thermal acclimation in the endothermic bluefin tuna (Thunnus orientalis).

    abstract::The temperature stress that pelagic fishes experience can induce physiological and behavioural changes that leave a signature in gene expression profiles. We used a functional genomics approach to identify genes that were up- or down-regulated following thermal stress in the Pacific bluefin tuna. Following the acclima...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Castilho PC,Buckley BA,Somero G,Block BA

    更新日期:2009-05-01 00:00:00

  • Fine-scale population structure and riverscape genetics of brook trout (Salvelinus fontinalis) distributed continuously along headwater channel networks.

    abstract::Linear and heterogeneous habitat makes headwater stream networks an ideal ecosystem in which to test the influence of environmental factors on spatial genetic patterns of obligatory aquatic species. We investigated fine-scale population structure and influence of stream habitat on individual-level genetic differentiat...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Kanno Y,Vokoun JC,Letcher BH

    更新日期:2011-09-01 00:00:00

  • Population differentiation of temperate amphibians in unpredictable environments.

    abstract::Amphibians are a globally distributed and diverse lineage, but much of our current understanding of their population genetic structure comes from studies in mesic temperate habitats. We characterize the population genetic structure of two sympatric explosive breeding amphibians in the southwestern deserts of the Unite...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Chan LM,Zamudio KR

    更新日期:2009-08-01 00:00:00

  • Lacustrine spatial distribution of landlocked Atlantic salmon populations assessed across generations by multilocus individual assignment and mixed-stock analyses.

    abstract::The objective of this study was to assess the spatiotemporal distribution of four landlocked Atlantic salmon (Salmo salar) populations during their sympatric feeding phase in lake St-Jean (Québec, Canada). A total of 1100 fish captured over a period of 25 years was genotyped at six microsatellite loci in order to asse...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Potvin C,Bernatchez L

    更新日期:2001-10-01 00:00:00

  • Diversity and divergence patterns in regulatory genes suggest differential gene flow in recently derived species of the Hawaiian silversword alliance adaptive radiation (Asteraceae).

    abstract::The impact of gene flow and population size fluctuations in shaping genetic variation during adaptive radiation, at both the genome-wide and gene-specific levels, is very poorly understood. To examine how historical population size and gene flow patterns within and between loci have influenced lineage divergence in th...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Lawton-Rauh A,Robichaux RH,Purugganan MD

    更新日期:2007-10-01 00:00:00

  • Origin and post-colonization evolution of the Chatham Islands skink (Oligosoma nigriplantare nigriplantare).

    abstract::Island ecosystems provide an opportunity to examine a range of evolutionary and ecological processes. The Chatham Islands are an isolated archipelago situated approximately 800 km east of New Zealand. Geological evidence indicates that the Chatham Islands re-emerged within the last 1-4 million years, following a prolo...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Liggins L,Chapple DG,Daugherty CH,Ritchie PA

    更新日期:2008-07-01 00:00:00

  • Phylogeography of a post-glacial colonizer: Microtus longicaudus (Rodentia: muridae).

    abstract::The molecular phylogeography of Microtus longicaudus was investigated with DNA sequences of the mitochondrial cytochrome b gene. We used phylogenetic and pairwise distance methods to reconstruct the history of the species with particular emphasis on the Pacific Northwest. Genetic variation across the species was consi...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Conroy CJ,Cook JA

    更新日期:2000-02-01 00:00:00

  • Conserving adaptive genetic diversity in dynamic landscapes.

    abstract::Genetic variation supplies the raw material for adaptation, evolution and survival of populations and has therefore been a key focus of conservation biology ever since its foundation (Soulé 1985). In previous decades, the neutral component of genetic diversity (generated by mutation and shaped by drift) has been the s...

    journal_title:Molecular ecology

    pub_type: 评论,杂志文章


    authors: Ficetola GF,Bonin AL

    更新日期:2011-04-01 00:00:00

  • Epigenetic variation predicts regional and local intraspecific functional diversity in a perennial herb.

    abstract::The ecological significance of epigenetic variation has been generally inferred from studies on model plants under artificial conditions, but the importance of epigenetic differences between individuals as a source of intraspecific diversity in natural plant populations remains essentially unknown. This study investig...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Medrano M,Herrera CM,Bazaga P

    更新日期:2014-10-01 00:00:00

  • Gynodioecy in structured populations: understanding fine-scale sex ratio variation in Beta vulgaris ssp. maritima.

    abstract::Natural selection, random processes and gene flow are known to generate sex ratio variations among sexually polymorphic plant populations. In gynodioecious species, in which hermaphrodites and females coexist, the relative effect of these processes on the maintenance of sex polymorphism is still up for debate. The aim...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: De Cauwer I,Dufay M,Hornoy B,Courseaux A,Arnaud JF

    更新日期:2012-02-01 00:00:00

  • Molecular phenotyping of maternally mediated parallel adaptive divergence within Rana arvalis and Rana temporaria.

    abstract::When similar selection acts on the same traits in multiple species or populations, parallel evolution can result in similar phenotypic changes, yet the underlying molecular architecture of parallel phenotypic divergence can be variable. Maternal effects can influence evolution at ecological timescales and facilitate l...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Shu L,Laurila A,Suter MJ,Räsänen K

    更新日期:2016-09-01 00:00:00

  • Genome scans on experimentally evolved populations reveal candidate regions for adaptation to plant resistance in the potato cyst nematode Globodera pallida.

    abstract::Improving resistance durability involves to be able to predict the adaptation speed of pathogen populations. Identifying the genetic bases of pathogen adaptation to plant resistances is a useful step to better understand and anticipate this phenomenon. Globodera pallida is a major pest of potato crop for which a resis...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Eoche-Bosy D,Gautier M,Esquibet M,Legeai F,Bretaudeau A,Bouchez O,Fournet S,Grenier E,Montarry J

    更新日期:2017-09-01 00:00:00

  • The emergence of the hyperinvasive vine, Mikania micrantha (Asteraceae), via admixture and founder events inferred from population transcriptomics.

    abstract::Biological invasions that involve well-documented rapid adaptations to new environments provide unequalled opportunities for testing evolutionary hypotheses. Mikania micrantha Kunth (Asteraceae), a perennial herbaceous vine native to tropical Central and South America, successfully invaded tropical Asia in the early 2...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Yang M,He Z,Huang Y,Lu L,Yan Y,Hong L,Shen H,Liu Y,Guo Q,Jiang L,Zhang Y,Greenberg AJ,Zhou R,Ge X,Wu CI,Shi S

    更新日期:2017-07-01 00:00:00

  • Shedding light on the evolution of plasticity in natural populations.

    abstract::Plasticity allows for changes in phenotype in response to environmental cues, often facilitating local adaptation to seasonal environments. Phenotypic plasticity alone, however, may not always be sufficient to ensure adaptation to new localities. In particular, changing cues associated with shifting seasonal regimes m...

    journal_title:Molecular ecology

    pub_type: 评论,杂志文章


    authors: Hyma KE,Caicedo AL

    更新日期:2011-09-01 00:00:00

  • Strong divergence in trait means but not in plasticity across hatchery and wild populations of sea-run brown trout Salmo trutta.

    abstract::There is ample evidence that organisms adapt to their native environment when gene flow is restricted. However, evolution of plastic responses across discrete environments is less well examined. We studied divergence in means and plasticity across wild and hatchery populations of sea-run brown trout (Salmo trutta) in ...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Rogell B,Dannewitz J,Palm S,Petersson E,Dahl J,Prestegaard T,Järvi T,Laurila A

    更新日期:2012-06-01 00:00:00

  • Fine-scale genetic structure and dispersal in cooperatively breeding apostlebirds.

    abstract::In cooperatively breeding species, restricted dispersal of offspring leads to clustering of closely related individuals, increasing the potential both for indirect genetic benefits and inbreeding costs. In apostlebirds (Struthidea cinerea), philopatry by both sexes results in the formation of large (up to 17 birds), p...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Woxvold IA,Adcock GJ,Mulder RA

    更新日期:2006-10-01 00:00:00

  • Molecular mechanisms of adaptation and speciation: why do we need an integrative approach?

    abstract::Understanding divergent adaptation and ecological speciation requires the synthesis of multiple approaches, including phenotypic characterization, genetics and genomics, realistic assessment of fitness and population genetic modelling. Current research in this field often approaches this problem from one of two direct...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Byers KJ,Xu S,Schlüter PM

    更新日期:2017-01-01 00:00:00

  • When can refuges mediate the genetic effects of fire regimes? A simulation study of the effects of topography and weather on neutral and adaptive genetic diversity in fire-prone landscapes.

    abstract::Understanding how landscape heterogeneity mediates the effects of fire on biodiversity is increasingly important under global changes in fire regimes. We used a simulation experiment to investigate how fire regimes interact with topography and weather to shape neutral and selection-driven genetic diversity under alter...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Banks SC,Davies ID,Cary GJ

    更新日期:2017-10-01 00:00:00

  • Strict monandry in the ponerine army ant genus Simopelta suggests that colony size and complexity drive mating system evolution in social insects.

    abstract::Altruism in social insects has evolved between closely related full-siblings. It is therefore of considerable interest why some groups have secondarily evolved low within-colony relatedness, which in turn affects the relatedness incentives of within-colony cooperation and conflict. The highest queen mating frequencies...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Kronauer DJ,O'Donnell S,Boomsma JJ,Pierce NE

    更新日期:2011-01-01 00:00:00

  • Population structure of the Chagas disease vector, Triatoma infestans, at the urban-rural interface.

    abstract::The increasing rate of biological invasions resulting from human transport or human-mediated changes to the environment has had devastating ecological and public health consequences. The kissing bug, Triatoma infestans, has dispersed through the Peruvian city of Arequipa. The biological invasion of this insect has res...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Foley EA,Khatchikian CE,Hwang J,Ancca-Juárez J,Borrini-Mayori K,Quıspe-Machaca VR,Levy MZ,Brisson D,Chagas Disease Working Group in Arequipa.

    更新日期:2013-10-01 00:00:00

  • Divergent evolutionary histories of two sympatric spruce bark beetle species.

    abstract::Ips typographus and Pityogenes chalcographus are two sympatric Palearctic bark beetle species with wide distribution ranges. As both species are comparable in biology, life history, and habitat, including sharing the same host, Picea abies, they provide excellent models for applying a comparative approach in which to ...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Bertheau C,Schuler H,Arthofer W,Avtzis DN,Mayer F,Krumböck S,Moodley Y,Stauffer C

    更新日期:2013-06-01 00:00:00

  • Evolutionary history of the Maltese wall lizard Podarcis filfolensis: insights on the ‘Expansion–Contraction’ model of Pleistocene biogeography.

    abstract::The expansion–contraction (EC) model predicts demographic and range contraction of temperate species during Pleistocene glaciations as a consequence of climate-related habitat changes, and provides a paradigm for explaining the high intraspecific diversity found in refugia in terms of long-term demographic stability. ...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Salvi D,Schembri PJ,Sciberras A,Harris DJ

    更新日期:2014-03-01 00:00:00

  • Phylogeography of the North American red fox: vicariance in Pleistocene forest refugia.

    abstract::Fossil, archaeological, and morphometric data suggest that indigenous red foxes in North America were derived from vicariance in two disjunct refugia during the last glaciation: one in Beringia and one in the contiguous USA. To test this hypothesis, we conducted a phylogeographical analysis of the North American red f...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Aubry KB,Statham MJ,Sacks BN,Perrine JD,Wisely SM

    更新日期:2009-06-01 00:00:00

  • Interspecific hybridization and restricted trans-Pacific gene flow in the Tropical Eastern Pacific Pocillopora.

    abstract::Coral reefs in the Tropical Eastern Pacific (TEP) are among the most isolated in the world. This isolation has resulted in relatively low species diversity but comparatively high endemism. The dominant reef-building corals of the TEP are the Pocillopora corals, a ubiquitous Indo-Pacific genus commonly regarded as infe...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Combosch DJ,Guzman HM,Schuhmacher H,Vollmer SV

    更新日期:2008-03-01 00:00:00

  • Rapid evolution of an adaptive cyanogenesis cline in introduced North American white clover (Trifolium repens L.).

    abstract::White clover is polymorphic for cyanogenesis (HCN production after tissue damage), and this herbivore defence polymorphism has served as a classic model for studying adaptive variation. The cyanogenic phenotype requires two interacting biochemical components; the presence/absence of each component is controlled by a s...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Kooyers NJ,Olsen KM

    更新日期:2012-05-01 00:00:00

  • Stochastic exits from dormancy give rise to heavy-tailed distributions of descendants in bacterial populations.

    abstract::Variance in reproductive success is a major determinant of the degree of genetic drift in a population. While many plants and animals exhibit high variance in their number of progeny, far less is known about these distributions for microorganisms. Here, we used a strain barcoding approach to quantify variability in of...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Wright ES,Vetsigian KH

    更新日期:2019-09-01 00:00:00

  • The legacy of a vanished sea: a high level of diversification within a European freshwater amphipod species complex driven by 15 My of Paratethys regression.

    abstract::The formation of continental Europe in the Neogene was due to the regression of the Tethys Ocean and of the Paratethys Sea. The dynamic geology of the area and repetitious transitions between marine and freshwater conditions presented opportunities for the colonization of newly emerging hydrological networks and diver...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Mamos T,Wattier R,Burzyński A,Grabowski M

    更新日期:2016-02-01 00:00:00

  • A tale of two flatties: different responses of two terrestrial flatworms to past environmental climatic fluctuations at Tallaganda in montane southeastern Australia.

    abstract::Comparative phylogeographic studies of animals with low mobility and/or high habitat specificity remain rare, yet such organisms may hold fine-grained palaeoecological signal. Comparisons of multiple, codistributed species can elucidate major historical events. As part of a multitaxon programme, mitochondrial cytochro...

    journal_title:Molecular ecology

    pub_type: 杂志文章


    authors: Sunnucks P,Blacket MJ,Taylor JM,Sands CJ,Ciavaglia SA,Garrick RC,Tait NN,Rowell DM,Pavlova A

    更新日期:2006-12-01 00:00:00