MHC class II beta sequence diversity in the deer mouse (Peromyscus maniculatus): implications for models of balancing selection.

Abstract:

:We studied population polymorphism at a major histocompatibility complex (MHC) class II beta gene in the deer mouse (Peromyscus maniculatus). We found that: (i) a single population of P. maniculatus has significantly higher levels of DNA and protein sequence diversity than worldwide samples from homologous genes in other taxa, including humans and mice; and (ii) the genealogy of allelic sequences in P. maniculatus deviates significantly from theoretical expectation under a model of symmetric balancing selection, in that alleles are relatively more divergent than expected. We suggest that the observation of high levels of pairwise allelic sequence divergence and deviation of the genealogy from theoretical expectation in P. maniculatus together provide support for a divergent allele advantage model for the maintenance of MHC polymorphism.

journal_name

Mol Ecol

journal_title

Molecular ecology

authors

Richman AD,Herrera LG,Nash D

doi

10.1046/j.0962-1083.2001.01402.x

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

2765-73

issue

12

eissn

0962-1083

issn

1365-294X

pii

1402

journal_volume

10

pub_type

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