Abstract:
:We studied population polymorphism at a major histocompatibility complex (MHC) class II beta gene in the deer mouse (Peromyscus maniculatus). We found that: (i) a single population of P. maniculatus has significantly higher levels of DNA and protein sequence diversity than worldwide samples from homologous genes in other taxa, including humans and mice; and (ii) the genealogy of allelic sequences in P. maniculatus deviates significantly from theoretical expectation under a model of symmetric balancing selection, in that alleles are relatively more divergent than expected. We suggest that the observation of high levels of pairwise allelic sequence divergence and deviation of the genealogy from theoretical expectation in P. maniculatus together provide support for a divergent allele advantage model for the maintenance of MHC polymorphism.
journal_name
Mol Ecoljournal_title
Molecular ecologyauthors
Richman AD,Herrera LG,Nash Ddoi
10.1046/j.0962-1083.2001.01402.xsubject
Has Abstractpub_date
2001-12-01 00:00:00pages
2765-73issue
12eissn
0962-1083issn
1365-294Xpii
1402journal_volume
10pub_type
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