Abstract:
:Recent studies that reveal a correlation between heterozygosity and fitness in natural populations have rekindled interest in whether balancing selection is widespread or an evolutionary oddity. We therefore quantified heterozygote advantage at 12 microsatellite markers in both inbred and outbred crosses of Drosophila grown under different forms of environmental stress. As expected, inbreeding depression reduces fitness relative to the outbred controls. In addition, many loci exhibit heterozygote advantage over and above any effect due to inbreeding, with approximately 30% of markers showing an effect in any given culture condition and approximately 75% of markers showing an effect in at least one of the four culture conditions. To explore the extent of linkage disequilibrium surrounding these loci we further typed four new markers close to each of the three strongest hits. We find a pattern where the extent of heterozygote excess tends to decline to nonsignificance within around 1.5 megabases (Mb) either side of the original hit. Crude extrapolation suggests 12 genes or regions experience detectable levels of heterozygote advantage in any one condition and as many as 25 overall. Thus, balancing selection is widespread and is likely to play an important role in maintaining genetic variability.
journal_name
Mol Ecoljournal_title
Molecular ecologyauthors
Ferreira AG,Amos Wdoi
10.1111/j.1365-294X.2006.03093.xsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
3885-93issue
13eissn
0962-1083issn
1365-294Xpii
MEC3093journal_volume
15pub_type
杂志文章abstract::SSCP (single-strand conformational polymorphism) is used widely in the field of human biomedicine, but its potential as a population genetics tool for the recovery of nuclear gene genealogies remains to be realized. We describe and illustrate a use for SSCP in the physical isolation of nuclear haplotypes that circumve...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1046/j.1365-294x.1997.00212.x
更新日期:1997-06-01 00:00:00
abstract::Infections with maternally inherited Wolbachia bacteria may have dramatic influences on reproductive traits and speciation patterns of their hosts. We here show that in the beetle genus Altica, infection has influenced phylogenetic patterns of the host's mtDNA and different strains led to repeated selective sweeps. By...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.12389
更新日期:2013-08-01 00:00:00
abstract::Recent advances in molecular biology and bioinformatics have helped to unveil striking and previously unrecognized patterns of geographic genetic structure in marine populations. Largely driven by the pressing needs of fisheries management and conservation, studies on marine fish populations have played a pivotal role...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2009.04404.x
更新日期:2009-12-01 00:00:00
abstract::The evolution of resistance to drugs and pesticides poses a major threat to human health and food security. Neonicotinoids are highly effective insecticides used to control agricultural pests. They target the insect nicotinic acetylcholine receptor and mutations of the receptor that confer resistance have been slow to...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.15503
更新日期:2020-07-01 00:00:00
abstract::Large-scale anthropogenic changes in the environment are reshaping global biodiversity and the evolutionary trajectory of many species. Evolutionary mechanisms that allow organisms to thrive in this rapidly changing environment are just beginning to be investigated (Hoffmann & Sgrò 2011; Colautti & Barrett 2013). Weed...
journal_title:Molecular ecology
pub_type: 评论,杂志文章
doi:10.1111/mec.12717
更新日期:2014-05-01 00:00:00
abstract::Anthropogenic habitat fragmentation of species that live in naturally patchy metapopulations such as mountaintops or sky islands experiences two levels of patchiness. Effects of such multilevel patchiness on species have rarely been examined. Metapopulation theory suggests that patchy habitats could have varied impact...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.13266
更新日期:2015-07-01 00:00:00
abstract::An increasing number of studies describe moving hybrid zones. This raises the issue of their actual frequency and emphasizes the need for methods that enable the detection of zone movements without historical records. Asymmetric introgression, usually considered as a signature of geographical shift, might be misleadin...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2006.02948.x
更新日期:2006-08-01 00:00:00
abstract::How males gain access to mates and the potential for female choice will determine whether polygyny can operate at several levels, from within litters and groups to the wider population. Female lesser flat-headed bats (Tylonycteris pachypus) form maternity groups in bamboo stems. Unusually for bats, they are multiparou...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2011.05192.x
更新日期:2011-09-01 00:00:00
abstract::Future climate scenarios predict changes in rainfall regimes. These changes are expected to affect plants via effects on the expression of root traits associated with water and nutrient uptake. Associated microorganisms may also respond to these new precipitation regimes, either directly in response to changes in the ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14536
更新日期:2018-04-01 00:00:00
abstract::Following the announcement of the first case of rabbit haemorrhagic disease (RHD) in a pet rabbit, housed indoors in Canada for more than 1 year, I submitted an evidence-based explanation to ProMed explaining how RHD might have caused the death of 'one' of the three pet rabbits. I suggested with supporting evidence, t...
journal_title:Molecular ecology
pub_type: 评论,信件
doi:10.1111/j.1365-294X.2012.05462.x
更新日期:2012-03-01 00:00:00
abstract::Euglossine bees (Apidae; Euglossini) exclusively pollinate hundreds of orchid species and comprise up to 25% of bee species richness in neotropical rainforests. As one of the first studies of comparative phylogeography in a neotropical insect group, we performed a mitochondrial DNA (mtDNA)-based analysis of 14 eugloss...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2004.02374.x
更新日期:2004-12-01 00:00:00
abstract::Inversion polymorphisms are responsible for many ecologically important phenotypes and are often found under balancing selection. However, the same features that ensure their large role in local adaptation-especially reduced recombination between alternate arrangements-mean that uncovering the precise loci within inve...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14880
更新日期:2019-03-01 00:00:00
abstract::Recent studies have highlighted an important role of structural variation (SV) in ecological and evolutionary processes, but few have studied nonmodel species in the wild. As part of our long-term research programme on the nonmodel teleost fish Australasian snapper (Chrysophrys auratus), we aim to build one of the fir...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.15051
更新日期:2019-03-01 00:00:00
abstract::In order to contribute to the debate about southern glacial refugia used by temperate species and more northern refugia used by boreal or cold-temperate species, we examined the phylogeography of a widespread snake species (Vipera berus) inhabiting Europe up to the Arctic Circle. The analysis of the mitochondrial DNA ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2006.03031.x
更新日期:2006-10-01 00:00:00
abstract::We used behavioural observations and mitochondrial DNA (mtDNA) sequence analysis to examine demographic and genetic structure within and among home-range groups of desert bighorn sheep (Ovis canadensis) ewes in the Peninsular Ranges of southern California, USA. We identified substantial genetic variation in the first ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1046/j.1365-294x.1999.00536.x
更新日期:1999-01-01 00:00:00
abstract::The ecosystem service of insect pest regulation by natural enemies, such as primary parasitoids, may be enhanced by the presence of uncultivated, semi-natural habitats within agro-ecosystems, although quantifying such host-parasitoid interactions is difficult. Here, we use rRNA 16S gene sequencing to assess both the l...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.12701
更新日期:2014-08-01 00:00:00
abstract::Spatially overdispersed mounds of fungus-farming termites (Macrotermitinae) are hotspots of nutrient availability and primary productivity in tropical savannas, creating spatial heterogeneity in communities and ecosystem functions. These termites influence the local availability of nutrients in part by redistributing ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.15585
更新日期:2020-11-01 00:00:00
abstract::On one night per year, at a specific point in the lunar cycle, one of the most extraordinary reproductive events on the planet unfolds as hundreds of millions of broadcast spawning corals release their trillions of gametes into the waters of the tropical seas. Each species spawns on a specific night within the lunar c...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14043
更新日期:2017-05-01 00:00:00
abstract::Mitochondrial DNA sequence data were obtained for eight species of flightless Galapaganus endemic weevils and one winged close relative in order to study their colonization history and modes of diversification in the Galápagos Archipelago. Contrary to most other insular radiations, the phylogeny estimates we recovered...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2007.03642.x
更新日期:2008-02-01 00:00:00
abstract::Ecosystems across the globe are threatened by climate change and human activities. New rapid survey approaches for monitoring biodiversity would greatly advance assessment and understanding of these threats. Taking advantage of next-generation DNA sequencing, we tested an approach we call metabarcoding: high-throughpu...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2012.05545.x
更新日期:2012-08-01 00:00:00
abstract::Studies of a hybrid zone between two house mouse subspecies (Mus musculus musculus and M. m. domesticus) along with studies using laboratory crosses reveal a large role for the X chromosome and multiple autosomal regions in reproductive isolation as a consequence of disrupted epistasis in hybrids. One limitation of pr...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2012.05583.x
更新日期:2012-06-01 00:00:00
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journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.13635
更新日期:2016-07-01 00:00:00
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journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1046/j.1365-294x.2003.01732.x
更新日期:2003-02-01 00:00:00
abstract::Determining the structure of bacterial communities and their response to stimuli is key to understanding community function and the interactions that occur between micro-organisms and the environment. However, bacterial communities often comprise complex assemblages of large numbers of different bacterial populations....
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294x.1995.tb00263.x
更新日期:1995-10-01 00:00:00
abstract::Threespine stickleback populations are model systems for studying adaptive evolution and the underlying genetics. In lakes on the Haida Gwaii archipelago (off western Canada), stickleback have undergone a remarkable local radiation and show phenotypic diversity matching that seen throughout the species distribution. T...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.12215
更新日期:2013-04-01 00:00:00
abstract::Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the stru...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.15004
更新日期:2019-03-01 00:00:00
abstract::Correlates between genetic diversity at intra- and interpopulation levels and the species diversity in plant communities are rarely investigated. Such correlates may give insights into the effect of local selective forces across different communities on the genetic diversity of local plant populations. This study has ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2004.02115.x
更新日期:2004-05-01 00:00:00
abstract::As natural selection must act on underlying genetic variation, discovering the number and location of loci under the influence of selection is imperative towards understanding adaptive divergence in evolving populations. Studies employing genome scans have hypothesized that the action of divergent selection should red...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2004.02396.x
更新日期:2005-02-01 00:00:00
abstract::Urban fragmentation can reduce gene flow that isolates populations, reduces genetic diversity and increases population differentiation, all of which have negative conservation implications. Alternatively, gene flow may actually be increased among urban areas consistent with an urban facilitation model. In fact, urban ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14783
更新日期:2018-07-04 00:00:00
abstract::The evolutionary mechanisms generating the tremendous biodiversity of islands have long fascinated evolutionary biologists. Genetic drift and divergent selection are predicted to be strong on islands and both could drive population divergence and speciation. Alternatively, strong genetic drift may preclude adaptation....
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.13605
更新日期:2016-05-01 00:00:00