A neuronal lactate uptake inhibitor slows recovery of extracellular ion concentration changes in the hippocampal CA3 region by affecting energy metabolism.

abstract：:1. Whole-cell patch clamp techniques were used to record transient outward potassium currents in embryonic rat neocortical neurons maintained in culture. The effect of lidocaine and its quaternary derivative QX222 on this transient outward current (TOC) was examined. 2. Extracellular application of lidocaine produced ...

journal_title：Journal of neurophysiology

authors： Andreasen M,Hablitz JJ

更新日期：1993-06-01 00:00:00

abstract：:1. Two subtypes of astrocytes that expressed distinctly different ion channel complements were identified in primary cultures from rat spinal cord and hippocampus using whole cell patch-clamp techniques. One population of cells expressed voltage-activated Na+ currents and displayed outwardly rectifying I-V relationshi...

journal_title：Journal of neurophysiology

authors： Ransom CB,Sontheimer H,Janigro D

更新日期：1996-07-01 00:00:00

abstract：:To explore the effects of acoustic and behavioral context on neuronal responses in the core of auditory cortex (fields A1 and R), two monkeys were trained on a go/no-go discrimination task in which they learned to respond selectively to a four-note target (S+) melody and withhold response to a variety of other nontarg...

journal_title：Journal of neurophysiology

authors： Yin P,Mishkin M,Sutter M,Fritz JB

更新日期：2008-12-01 00:00:00

abstract：:The mouse is an important model system for investigating the neural circuits mediating behavior. Because of advances in imaging and optogenetic methods, head-fixed mouse preparations provide an unparalleled opportunity to observe and control neural circuits. To investigate how neural circuits produce behavior, these m...

journal_title：Journal of neurophysiology

authors： Sanders JI,Kepecs A

更新日期：2012-12-01 00:00:00

abstract：:AMPA-type glutamate receptors are normally Ca(2+) impermeable due to the expression of the GluR2 receptor subunit. By using GluR2 null mice we were able to detect miniature synaptic Ca(2+) transients (MSCTs) associated with AMPA-type receptor-mediated miniature synaptic currents at single synapses in primary cortical ...

journal_title：Journal of neurophysiology

authors： Wang S,Jia Z,Roder J,Murphy TH

更新日期：2002-07-01 00:00:00

abstract：:Changes in temperature of up to several degrees have been reported in different brain regions during various behaviors or in response to environmental stimuli. We investigated temperature sensitivity of dopaminergic neurons of the rat substantia nigra pars compacta (SNc), an area important for motor and emotional cont...

journal_title：Journal of neurophysiology

authors： Guatteo E,Chung KK,Bowala TK,Bernardi G,Mercuri NB,Lipski J

更新日期：2005-11-01 00:00:00

abstract：:Subjects were asked to track, with their eyes or their hand, the movement of a target that maintained a constant speed and made a single, abrupt change in direction. The tracking speed and direction of motion after the step change in target direction were compared for the eyes and the hand. After removal of the saccad...

journal_title：Journal of neurophysiology

authors： Engel KC,Anderson JH,Soechting JF

更新日期：2000-09-01 00:00:00

abstract：:1. GABAergic mechanisms in the midbrain periaqueductal gray (PAG) have been proposed to control the activity of descending antinociceptive systems and defensive behavior. Here, the effect of neuronal disinhibition by gamma-aminobutyric acid (GABAA) receptor blockade at midbrain sites on spinal neuronal responses to no...

journal_title：Journal of neurophysiology

authors： Sandkühler J,Willmann E,Fu QG

更新日期：1991-01-01 00:00:00

abstract：:The cerebral cortex, the neostriatum (Str), and the external segment of the globus pallidus (GPe) form a cortico-Str-GPe disynaptic connection, which is one of the major connections in the basal ganglia circuitries and a target of dopamine modulation. The aim of this study was to examine the actions of D2-like dopamin...

journal_title：Journal of neurophysiology

authors： Watanabe K,Kita T,Kita H

更新日期：2009-02-01 00:00:00

abstract：:In adult songbirds, auditory neurons in the primary auditory forebrain region of field L and a secondary auditory forebrain region of caudal mesopallium (CM) are highly responsive to natural sounds, such as conspecific song. Because these nuclei are involved in sensory representations of songs, we investigated how the...

journal_title：Journal of neurophysiology

authors： Amin N,Doupe A,Theunissen FE

更新日期：2007-05-01 00:00:00

abstract：:In common with other sensory cortices, the mammalian primary auditory cortex (AI) demonstrates the capacity for large-scale reorganization following many experimental situations. For example, training animals in frequency-discrimination tasks has been shown to result in an increase in cortical frequency representation...

journal_title：Journal of neurophysiology

authors： Talwar SK,Gerstein GL

更新日期：2001-10-01 00:00:00

abstract：:Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor (GABABR...

journal_title：Journal of neurophysiology

authors： Pennock RL,Hentges ST

更新日期：2016-06-01 00:00:00

abstract：:1. A brain slice preparation was used to study the hypoglossal (XII) neuronal response to anoxia. Both intra- and extracellular potassium activities (K+i,K+o) were measured by the use of ion-selective microelectrodes, and K+ flux was assessed by the use of pharmacologic blockers. 2. Extracellular recordings showed tha...

journal_title：Journal of neurophysiology

authors： Jiang C,Haddad GG

更新日期：1991-07-01 00:00:00

abstract：:In the mammalian vestibular periphery, electrical activation of the efferent vestibular system (EVS) has two effects on afferent activity: 1) it increases background afferent discharge and 2) decreases afferent sensitivity to rotational stimuli. Although the cellular mechanisms underlying these two contrasting afferen...

journal_title：Journal of neurophysiology

authors： Poppi LA,Tabatabaee H,Drury HR,Jobling P,Callister RJ,Migliaccio AA,Jordan PM,Holt JC,Rabbitt RD,Lim R,Brichta AM

更新日期：2018-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the most common neurological disorders causing memory reduction, particularly short-term memory (STM). We showed that, during TBI-induced inflammation, increased blood content of fibrinogen (Fg) enhanced vascular protein transcytosis and deposition of extravasated Fg in vasculo-a...

journal_title：Journal of neurophysiology

authors： Charkviani M,Muradashvili N,Sulimai N,Lominadze D

更新日期：2020-08-01 00:00:00

abstract：:Visual search is a ubiquitous visual behavior, and efficient search is essential for survival. Different cognitive models have explained the speed and accuracy of search based either on the dynamics of attention or on similarity of item representations. Here, we examined the extent to which performance on a visual sea...

journal_title：Journal of neurophysiology

authors： Cohen MA,Alvarez GA,Nakayama K,Konkle T

更新日期：2017-01-01 00:00:00

abstract：:Substance P (SP) is an undecapeptide that is co-localized with conventional transmitters in the nucleus accumbens (NAc). Its neurochemical and behavioral effects resemble those of cocaine and amphetamine. How SP accomplishes these effects is not known, partly because its cellular and synaptic effects are not well char...

journal_title：Journal of neurophysiology

authors： Kombian SB,Ananthalakshmi KV,Parvathy SS,Matowe WC

更新日期：2003-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) can potentiate synaptic release at newly developed frog neuromuscular junctions. Although this potentiation depends on extracellular Ca(2+) and reflects changes in acetylcholine release, little is known about the intracellular transduction or calcium signaling pathways. We have...

journal_title：Journal of neurophysiology

authors： Kleiman RJ,Tian N,Krizaj D,Hwang TN,Copenhagen DR,Reichardt LF

更新日期：2000-07-01 00:00:00

abstract：:Because vagal and sympathetic inputs activate upper cervical spinal neurons, we hypothesized that stimulation of the esophagus would activate C(1)-C(2) neurons. This study examined responses of C(1)-C(2) spinal neurons to cervical and thoracic esophageal distension (CED, TED) and afferent pathways for CED and TED inpu...

journal_title：Journal of neurophysiology

authors： Qin C,Chandler MJ,Jou CJ,Foreman RD

更新日期：2004-05-01 00:00:00

abstract：:Transient neurophysiological changes in CA3 neurons and dentate granule cells after severe forebrain ischemia in vivo. J. Neurophysiol. 80: 2860-2869, 1998. The spontaneous activities, evoked synaptic responses, and membrane properties of CA3 pyramidal neurons and dentate granule cells in rat hippocampus were compared...

journal_title：Journal of neurophysiology

authors： Gao TM,Howard EM,Xu ZC

更新日期：1998-12-01 00:00:00

abstract：:The forebrain plays an important role in many aspects of sound localization behavior. Yet, the forebrain pathway that processes auditory spatial information is not known for any species. Using standard anatomic labeling techniques, we used a "top-down" approach to trace the flow of auditory spatial information from an...

journal_title：Journal of neurophysiology

authors： Cohen YE,Miller GL,Knudsen EI

更新日期：1998-02-01 00:00:00

abstract：:In rats, whisker trimming during development leads to persistent alterations in the function of cortical barrel circuits and to behavioral deficits later in life. Here we examined how whisker trimming begun either at birth (P0) or on postnatal day 12 (P12), around the onset of whisking behavior, affects receptive fiel...

journal_title：Journal of neurophysiology

authors： Shoykhet M,Land PW,Simons DJ

更新日期：2005-12-01 00:00:00

abstract：:Fine flexible wire microelectrodes chronically implanted in the fifth lumbar ventral root (L5 VR) of 17 cats rendered stable records of the natural discharge patterns of 164 individual axons during locomotion on a treadmill. Fifty-one out of 164 axons were identified as motoneurons projecting to the anterior thigh mus...

journal_title：Journal of neurophysiology

authors： Hoffer JA,Loeb GE,Marks WB,O'Donovan MJ,Pratt CA,Sugano N

更新日期：1987-02-01 00:00:00

abstract：:When identical stimuli are presented in rapid temporal succession, neural responses to the second stimulation are often weaker than those observed for the first. This phenomenon is termed sensory gating and is believed to be an adaptive feature that helps prevent higher-order cortical centers from being flooded with u...

journal_title：Journal of neurophysiology

authors： Arpin DJ,Gehringer JE,Wilson TW,Kurz MJ

更新日期：2017-10-01 00:00:00

abstract：:1. We describe a four-layered neural network (Fig. 1), based on the input organization of a collision signaling neuron in the visual system of the locust, the lobula giant movement detector (LGMD). The 250 photoreceptors ("P" units) in layer 1 are excited by any change in illumination, generated when an image edge pas...

journal_title：Journal of neurophysiology

authors： Rind FC,Bramwell DI

更新日期：1996-03-01 00:00:00

abstract：:We charted postnatal changes in the intrinsic electrophysiological properties and synaptic responses of rat intrinsic cardiac ganglion (ICG) neurons. We developed a whole-mount ganglion preparation of the excised right atrial ganglion plexus. Using intracellular recordings and nerve stimulation we tested the hypothesi...

journal_title：Journal of neurophysiology

authors： Rimmer K,Harper AA

更新日期：2006-06-01 00:00:00

abstract：:Controlled whisker stimulation and single-unit recordings were used to elucidate response transformations that occur during the processing of tactile information from ventral posterior medial thalamus (VPM) through cortical columns in the rat whisker/barrel cortex. Whiskers were either deflected alone, using punctate ...

journal_title：Journal of neurophysiology

authors： Brumberg JC,Pinto DJ,Simons DJ

更新日期：1999-10-01 00:00:00

abstract：:Sexually dimorphic behaviors develop under the influence of sex steroids, which induce reversible changes in the underlying neural network of the brain. However, little is known about the proteins that mediate these activational effects of sex steroids. Here, we used a proteomics approach for large-scale identificatio...

journal_title：Journal of neurophysiology

authors： Zupanc GK,Ilies I,Sîrbulescu RF,Zupanc MM

更新日期：2014-04-01 00:00:00

abstract：:Interneuron precursors transplanted into visual cortex induce network plasticity during their heterochronic maturation. Such plasticity can have a significant impact on the function of the animal and is normally present only during a brief critical period in early postnatal development. Elucidating the synaptic and ph...

journal_title：Journal of neurophysiology

authors： Larimer P,Spatazza J,Stryker MP,Alvarez-Buylla A,Hasenstaub AR

更新日期：2017-07-01 00:00:00

abstract：:Following stepping in-place on the surface of a rotating circular treadmill, a subject attempting to step in-place or walk in a straight line across the floor without vision will rotate relative to space. This adaptation, termed podokinetic after-rotation (PKAR), transfers to backward walking following forward walking...

journal_title：Journal of neurophysiology

authors： Earhart GM,Melvill Jones G,Horak FB,Block EW,Weber KD,Fletcher WA

更新日期：2002-02-01 00:00:00