Responses and afferent pathways of C1-C2 spinal neurons to cervical and thoracic esophageal stimulation in rats.

Abstract:

:Because vagal and sympathetic inputs activate upper cervical spinal neurons, we hypothesized that stimulation of the esophagus would activate C(1)-C(2) neurons. This study examined responses of C(1)-C(2) spinal neurons to cervical and thoracic esophageal distension (CED, TED) and afferent pathways for CED and TED inputs to C(1)-C(2) spinal neurons. Extracellular potentials of single C(1)-C(2) spinal neurons were recorded in pentobarbital-anesthetized male rats. Graded CED or TED was produced by water inflation (0.1-0.5 ml) of a latex balloon. CED changed activity of 48/219 (22%) neurons; 34 were excited (E), 12 were inhibited (I), and 2 were E-I. CED elicited responses for 18/18 neurons tested after ipsilateral cervical vagotomy, for 12/14 neurons tested after bilateral vagotomy and for 9/11 neurons tested after bilateral vagotomy and C(6)-C(7) spinal cord transection. TED changed activity of 31/190 (16%) neurons (28E, 3 I). Ipsilateral cervical vagotomy abolished TED-evoked responses of 5/12 neurons. Bilateral vagotomy eliminated responses of 2/4 neurons tested, and C(6)-C(7) spinal transection plus bilateral vagotomy eliminated responses of 2/2 neurons. Thus inputs from CED to C(1)-C(2) neurons most likely entered upper cervical dorsal roots, whereas inputs from TED were dependent on vagal pathways and/or sympathetic afferent pathways that entered the thoracic dorsal roots. These results supported a concept that C(1)-C(2) spinal neurons play a role in integrating visceral information from cervical and thoracic esophagus.

journal_name

J Neurophysiol

authors

Qin C,Chandler MJ,Jou CJ,Foreman RD

doi

10.1152/jn.00971.2003

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

2227-35

issue

5

eissn

0022-3077

issn

1522-1598

pii

00971.2003

journal_volume

91

pub_type

杂志文章
  • Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study.

    abstract::The increasing use of transgenic mice for the study of pain mechanisms necessitates comprehensive understanding of the murine somatosensory system. Using an in vivo mouse preparation, we studied response properties of tibial nerve afferent fibers innervating glabrous skin. Recordings were obtained from 225 fibers iden...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.4.1561

    authors: Cain DM,Khasabov SG,Simone DA

    更新日期:2001-04-01 00:00:00

  • Antisaccade cost is modulated by contextual experience of location probability.

    abstract::It is well known that pro- and antisaccades may deploy different cognitive processes. However, the specific reason why antisaccades have longer latencies than prosaccades is still under debate. In three experiments, we studied the factors contributing to the antisaccade cost by taking attentional orienting and target ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00815.2009

    authors: Liu CL,Chiau HY,Tseng P,Hung DL,Tzeng OJ,Muggleton NG,Juan CH

    更新日期:2010-03-01 00:00:00

  • Ocular responses to brief motion of textured backgrounds during smooth pursuit in humans.

    abstract::We studied the effects of horizontal smooth pursuit on the ocular responses to brief vertical perturbations of textured backgrounds in humans. When the subject was fixating on a stationary target, a brief vertical perturbation of the background elicited a small tracking response. When the subject was pursuing a target...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00430.2009

    authors: Miura K,Kobayashi Y,Kawano K

    更新日期:2009-09-01 00:00:00

  • Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis.

    abstract::Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, is caused by loss of the fragile X mental retardation protein (FMRP). FMRP is a negative regulator of local mRNA translation downstream of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation. In the absence of FMRP there is...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00449.2010

    authors: Auerbach BD,Bear MF

    更新日期:2010-08-01 00:00:00

  • Contribution of synaptic depression to phase maintenance in a model rhythmic network.

    abstract::In many rhythmic neuronal networks that operate in a wide range of frequencies, the time of neuronal firing relative to the cycle period (the phase) is invariant. This invariance suggests that when frequency changes, firing time is precisely adjusted either by intrinsic or synaptic mechanisms. We study the maintenance...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00411.2003

    authors: Manor Y,Bose A,Booth V,Nadim F

    更新日期:2003-11-01 00:00:00

  • Dendritic spikes and their influence on extracellular calcium signaling.

    abstract::Extracellular calcium is critical for many neural functions, including neurotransmission, cell adhesion, and neural plasticity. Experiments have shown that normal neural activity is associated with changes in extracellular calcium, which has motivated recent computational work that employs such fluctuations in an info...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.3.1329

    authors: Wiest MC,Eagleman DM,King RD,Montague PR

    更新日期:2000-03-01 00:00:00

  • Synchrony in normal and focal epileptic brain: the seizure onset zone is functionally disconnected.

    abstract::Synchronization of local and distributed neuronal assemblies is thought to underlie fundamental brain processes such as perception, learning, and cognition. In neurological disease, neuronal synchrony can be altered and in epilepsy may play an important role in the generation of seizures. Linear cross-correlation and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00368.2010

    authors: Warren CP,Hu S,Stead M,Brinkmann BH,Bower MR,Worrell GA

    更新日期:2010-12-01 00:00:00

  • Potassium currents in octopus cells of the mammalian cochlear nucleus.

    abstract::Octopus cells in the posteroventral cochlear nucleus (PVCN) of mammals are biophysically specialized to detect coincident firing in the population of auditory nerve fibers that provide their synaptic input and to convey its occurrence with temporal precision. The precision in the timing of action potentials depends on...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.5.2299

    authors: Bal R,Oertel D

    更新日期:2001-11-01 00:00:00

  • Neural organization from the superior colliculus to motoneurons in the horizontal oculomotor system of the cat.

    abstract::The neural organization of the superior colliculus (SC) projection to horizontal ocular motoneurons was analyzed in anesthetized cats using intracellular recording and transneuronal labeling. Intracellular responses to SC stimulation were analyzed in lateral rectus (LR) and medial rectus (MR) motoneurons and internucl...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.6.2597

    authors: Izawa Y,Sugiuchi Y,Shinoda Y

    更新日期:1999-06-01 00:00:00

  • Spinal cord direct current stimulation differentially modulates neuronal activity in the dorsal and ventral spinal cord.

    abstract::Spinal cord direct current stimulation (sDCS) has the potential for promoting motor function after injury through its modulatory actions on sensory processing, reflex functions, the motor cortex (M1) motor map, and motor output. Here we addressed systems-level mechanisms underlying sDCS neuromodulation of spinal circu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00584.2016

    authors: Song W,Martin JH

    更新日期:2017-03-01 00:00:00

  • Single-channel properties of a G-protein-coupled inward rectifier potassium channel in brain neurons.

    abstract::1. In cultured rat locus coeruleus neurons, somatostatin or met-enkephalin induces an inwardly rectifying K+ conductance. This inward rectifier was analyzed at the single-channel level. 2. Using the inside-out patch-clamp, guanosine 5'-triphosphate (GTP) application to the cytoplasmic side in the presence of somatosta...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.1.318

    authors: Grigg JJ,Kozasa T,Nakajima Y,Nakajima S

    更新日期:1996-01-01 00:00:00

  • Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+.

    abstract::1. The effects of the di- and trivalent trace metal cations, Pb2+, Zn2+, and Al3+, on voltage-activated calcium channel currents recorded from cultured rat dorsal root ganglion neurons were determined. 2. All three cations blocked transient and sustained components of the voltage-gated calcium channel currents elicite...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.4.1491

    authors: Büsselberg D,Platt B,Michael D,Carpenter DO,Haas HL

    更新日期:1994-04-01 00:00:00

  • Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem.

    abstract::Cardiovascular function is regulated by a dynamic balance composed of sympathetic and parasympathetic activity. Sympathoexcitatory presympathetic neurons (PSNs) in the rostral ventrolateral medulla project directly to cardiac and vasomotor sympathetic preganglionic neurons in the spinal cord. In proximity to the PSNs ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01054.2012

    authors: Dergacheva O,Boychuk CR,Mendelowitz D

    更新日期:2013-08-01 00:00:00

  • Optogenetic fMRI sheds light on the neural basis of the BOLD signal.

    abstract::Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neuro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00535.2010

    authors: Palmer HS

    更新日期:2010-10-01 00:00:00

  • Neuron activity in monkey vestibular nuclei during vertical vestibular stimulation and eye movements.

    abstract::To elucidate how information is processed in the vestibuloocular reflex (VOR) pathways subserving vertical eye movements, extracellular single-unit recordings were obtained from the vestibular nuclei of alert monkeys trained to track a visual target with their eyes while undergoing sinusoidal pitch oscillations (0.2-1...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1984.52.4.724

    authors: Chubb MC,Fuchs AF,Scudder CA

    更新日期:1984-10-01 00:00:00

  • Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor.

    abstract::The amino acid sequence of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B from the brown ghost knife fish Apteronotus leptorhynchus has been determined and compared with the sequence of the murine NR2B. This comparison revealed high levels of sequence conservation throughout the ligand binding and membrane span...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00629.2002

    authors: Harvey-Girard E,Dunn RJ

    更新日期:2003-02-01 00:00:00

  • Motor but not sensory representation in motor cortex depends on postsynaptic activity during development and in maturity.

    abstract::The movement representation in the primary motor cortex (M1) of the cat develops between postnatal weeks 7-12. The somatosensory representation in motor cortex is present by the age that the motor map begins to develop. In this study we examined the role of neural activity in development and maintenance of the M1 move...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00424.2005

    authors: Chakrabarty S,Martin JH

    更新日期:2005-11-01 00:00:00

  • Kinematics of eye movements of cats to broadband acoustic targets.

    abstract::Operant conditioning was used to train cats with their heads immobilized to localize sound by directing their eyes to the location of the sources. The kinematics of those eye movements were studied and compared with eye movements to visual targets at the same locations. The main finding of this study is that eye movem...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.2.955

    authors: Populin LC,Yin TC

    更新日期:1999-08-01 00:00:00

  • Substance P depresses excitatory synaptic transmission in the nucleus accumbens through dopaminergic and purinergic mechanisms.

    abstract::Substance P (SP) is an undecapeptide that is co-localized with conventional transmitters in the nucleus accumbens (NAc). Its neurochemical and behavioral effects resemble those of cocaine and amphetamine. How SP accomplishes these effects is not known, partly because its cellular and synaptic effects are not well char...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00854.2002

    authors: Kombian SB,Ananthalakshmi KV,Parvathy SS,Matowe WC

    更新日期:2003-02-01 00:00:00

  • Functional properties of ryanodine receptors in hippocampal neurons change during early differentiation in culture.

    abstract::6-((4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl)amino)hexanoic acid ryanodine (BODIPY-ryanodine) binding and Ca(2+) imaging were used to study the properties of ryanodine receptors (RyRs) and cytoplasmic Ca(2+) (Ca) changes in neurons cultured from the embryonic rat hippocampus during the earli...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.3.1077

    authors: Sukhareva M,Smith SV,Maric D,Barker JL

    更新日期:2002-09-01 00:00:00

  • 9-16 Hz oscillation precedes secondary generalization of seizures in the rat tetanus toxin model of epilepsy.

    abstract::Unilateral intrahippocampal injection of tetanus toxin results in a chronic syndrome of intermittent epileptic seizures. During some of these seizures, rats develop a stereotypic, pathological motor behavior that indicates secondary generalization of epileptic activity. We report that secondary generalization was prec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2217

    authors: Finnerty GT,Jefferys JG

    更新日期:2000-04-01 00:00:00

  • Distinct local circuits between neocortical pyramidal cells and fast-spiking interneurons in young adult rats.

    abstract::Connections between layer V pyramidal cells and GABAergic fast-spiking interneurons (pyramidal-FS) were studied by paired recordings combined with morphological analyses in acute neocortical slices from 28- to 52-day-old rats. Pairs of spikes elicited in pyramidal cells at a stimulation rate of 0.2 Hz induced unitary ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00750.2002

    authors: Angulo MC,Staiger JF,Rossier J,Audinat E

    更新日期:2003-02-01 00:00:00

  • Presynaptic plasticity in an immature neocortical network requires NMDA receptor activation and BDNF release.

    abstract::Activity-dependent developmental maturation of the neocortical network is thought to involve the stabilization and potentiation of immature synapses. In particular, N-methyl-d-aspartate (NMDA) receptor-dependent long-term plasticity that is expressed presynaptically appears to be crucial for the selection of functiona...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00018.2006

    authors: Walz C,Jüngling K,Lessmann V,Gottmann K

    更新日期:2006-12-01 00:00:00

  • Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons.

    abstract::Pharmacological modulation of gamma-aminobutyric acid-A (GABAA) receptors can provide important information on the types of subunits composing these receptors. In recombinant studies, zinc more potently inhibits alphabeta subunits compared with the alphabetagamma combination, whereas modulation by nanomolar concentrat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.4.1670

    authors: Defazio T,Hablitz JJ

    更新日期:1998-10-01 00:00:00

  • Mechanosensitive properties of gastric vagal afferent fibers in the rat.

    abstract::Single, teased fiber recordings were made from the decentralized right cervical vagus nerve (hyponodal) of the rat. A total of 67 afferent fibers that responded to gastric distension (GD) were studied: 9 fibers were stimulated by phasic balloon GD, 58 by more natural fluid GD. All balloon GD-responsive fibers had rest...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.5.2210

    authors: Ozaki N,Sengupta JN,Gebhart GF

    更新日期:1999-11-01 00:00:00

  • Spike frequency adaptation and signaling properties of identified neurons in rodent deep spinal dorsal horn.

    abstract::Using whole cell recordings, I analyzed the intrinsic discharge properties for 285 neurons in Rexed's laminae III-V of isolated hamster spinal cord preparations. Neurons were characterized by their responses to step-wise and ramp-hold depolarizing current applied through the recording pipettes. Tonic cells (133/285; 4...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01012.2002

    authors: Schneider SP

    更新日期:2003-07-01 00:00:00

  • Mechanisms of depolarizing inhibition at the crayfish giant motor synapse. I. Electrophysiology.

    abstract::1. Mechanisms of depolarizing synaptic inhibition were investigated at the crayfish giant motor synapse with the use of two-electrode current- and voltage-clamp techniques. Depolarizing inhibitory postsynaptic potentials (d-IPSPs) of between 5 and 15 mV in amplitude are produced there in the motor giant motoneuron (Mo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.64.2.532

    authors: Edwards DH

    更新日期:1990-08-01 00:00:00

  • Movement speed is biased by prior experience.

    abstract::How does the motor system choose the speed for any given movement? Many current models assume a process that finds the optimal balance between the costs of moving fast and the rewards of achieving the goal. Here, we show that such models also need to take into account a prior representation of preferred movement speed...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00522.2013

    authors: Hammerbeck U,Yousif N,Greenwood R,Rothwell JC,Diedrichsen J

    更新日期:2014-01-01 00:00:00

  • Response of vestibular neurons to head rotations in vertical planes. II. Response to neck stimulation and vestibular-neck interaction.

    abstract::1. We have studied the responses of neurons in the lateral and descending vestibular nuclei of decerebrate cats to stimulation of neck receptors, produced by rotating the body in vertical planes with the head stationary. The responses to such neck stimulation were compared with the responses to vestibular stimulation ...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.1988.60.5.1765

    authors: Kasper J,Schor RH,Wilson VJ

    更新日期:1988-11-01 00:00:00

  • Suppression of putative tinnitus-related activity by extra-cochlear electrical stimulation.

    abstract::Studies on animals have shown that noise-induced hearing loss is followed by an increase of spontaneous firing at several stages of the central auditory system. This central hyperactivity has been suggested to underpin the perception of tinnitus. It was shown that decreasing cochlear activity can abolish the noise-ind...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00580.2014

    authors: Noreña AJ,Mulders WH,Robertson D

    更新日期:2015-01-01 00:00:00