Intestinal ameliorative effects of traditional Ogi-tutu, Vernonia amygdalina and Psidium guajava in mice infected with Vibrio cholera.

Abstract:

BACKGROUND:Cholera, a severe acute watery diarrhea caused by Vibrio cholerae is endemic in Nigeria with most cases occurring in the rural areas. In South West Nigeria, some individuals resort to alternative treatments such as Ogi-tutu, Psidium guajava and Vernonia amygdalina during infections. The effectiveness of these alternatives in the prevention and treatment of V. cholerae infection requires experimental investigation. OBJECTIVE:This study was designed to investigate the ameliorative effects of Ogi-tutu, Vernonia amygdalina and Psidium guajava on intestinal histopathology of experimental mice infected with V. cholerae. METHODS:Preliminary investigation of in vitro vibriocidal activities of these alternatives were carried out using agar cup diffusion assay. For ameliorative effects, adult mice were inoculated with 100 µl (106 cells) of Vibrio cholerae and dosed at 0 h (immediate prevention) and 4 h (treatment of infection) and their intestines were histopathologically evaluated. RESULTS:The histopathological changes were the same irrespective of the treated groups, but the lesions varied in extent and severity. The ameliorative effects in decreasing order were V. amygdalina > P. guajava > Ogi-tutu. CONCLUSION:V. amygdalina gave the best ameliorative effects in the prevention and treatment of V. cholerae infection.

journal_name

Afr Health Sci

journal_title

African health sciences

authors

Shittu OB,Ajayi OL,Bankole SO,Popoola TO

doi

10.4314/ahs.v16i2.33

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

620-8

issue

2

eissn

1680-6905

issn

1729-0503

pii

jAFHS.v16.i2.pg620

journal_volume

16

pub_type

杂志文章
  • Molecular characterization of Hymenolepis nana based on nuclear rDNA ITS2 gene marker.

    abstract:Introduction:Hymenolepis nana is a zoonotic tapeworm with widespread distribution. The goal of the present study was to identify the parasite in the specimens collected from NorthWestern regions of Iran using PCR-sequencing method. Methods:A total of 1521 stool samples were collected from the study individuals. Initia...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i1.6

    authors: Shahnazi M,Mehrizi MZ,Alizadeh SA,Heydarian P,Saraei M,Alipour M,Hajialilo E

    更新日期:2019-03-01 00:00:00

  • Viral load, CD4+ T-lymphocyte counts and antibody titres in HIV-1 infected untreated children in Kenya; implication for immunodeficiency and AIDS progression.

    abstract:BACKGROUND:There are limited reports on HIV-1 RNA load, CD4+ T-lymphocytes and antibody responses in relation to disease progression in HIV-1 infected untreated children in Africa. METHODS:To describe the relationships between these parameters, we conducted a longitudinal cohort study involving 51 perinatally HIV-1 in...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.5555/afhs.2006.6.1.3

    authors: Ochieng W,Ogoyi D,Mulaa FJ,Ogola S,Musoke R,Otsyula MG

    更新日期:2006-03-01 00:00:00

  • Opiate withdrawal syndrome in buprenorphine abusers admitted to a rehabilitation center in Tunisia.

    abstract:BACKGROUND:Illicit use of high dosage buprenorphine has been well documented in several countries, including Tunisia. OBJECTIVES:The aim of this survey is to assess the buprenorphine withdrawal syndrome time course, and how it may be affected by the population characteristics among subjects admitted to a rehabilitatio...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v16i4.24

    authors: Derbel I,Ghorbel A,Akrout FM,Zahaf A

    更新日期:2016-12-01 00:00:00

  • Attitude of Lesotho health care workers towards HIV/AIDS and impact of HIV/AIDS on the population structure.

    abstract:BACKGROUND:The impact and management of HIV/AIDS in Lesotho in the context of disaster management was investigated. OBJECTIVES:Lesotho health care workers' perception on HIV/AIDS progression, whether HIV/AIDS was managed as a disaster, and the impact on the demographic profile was investigated. METHODS:The empirical ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i4.36

    authors: Belle JA,Ferriera SB,Jordaan A

    更新日期:2013-12-01 00:00:00

  • Integrated management of HIV/NCDs: knowledge, attitudes, and practices of health care workers in Gaborone, Botswana.

    abstract:Background:The epidemiologic transition and double disease burden from chronic infections and Non-communicable diseases (NCDs) worldwide requires re-engineering of healthcare delivery systems. Healthcare workers (HCWs) need to adapt to new integrated disease management approaches and change from current disease-specifi...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i3.3

    authors: Masupe T,Mashalla Y,Seloilwe E,Jibril H,Medhin H

    更新日期:2019-09-01 00:00:00

  • Effect of target controlled propofol infusion versus intermittent boluses during oesophagogastroduodenoscopy: a randomized controlled trial.

    abstract:Background:Propofol is administered as intermittent boluses to achieve deep sedation to facilitate oesophagogastroduodenoscopy. Target controlled infusion (TCI) can be employed for this purpose. Methods:176 adults were randomly allocated into two groups of 88 patients. Control group: Received an initial bolus of propo...

    journal_title:African health sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.4314/ahs.v19i4.36

    authors: Ndosi C,Mung'ayi V,Gisore E,Mir S

    更新日期:2019-12-01 00:00:00

  • Depression among medical students in Alexandria, Egypt.

    abstract:Background:Depression is a common illness worldwide with high rate among medical students. The objectives were to estimate the prevalence of depression among medical students in Alexandria, and identify its correlates. Methods:A cross-sectional study design was used. The study was conducted at the Faculty of Medicine,...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i3.47

    authors: Elsawy WIH,Sherif AAR,Attia MSED,El-Nimr NA

    更新日期:2020-09-01 00:00:00

  • Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study.

    abstract:Background:The aim of this study was to determine the prevalence and factors associated with microalbuminuria among newly diagnosed diabetic patients in Mulago National Referral Hospital, Uganda. Methods:In this cross-sectional study conducted between June 2014 and January 2015, we collected information on patients' s...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i1.36

    authors: Muddu M,Mutebi E,Ssinabulya I,Kizito S,Mulindwa F,Kiiza CM

    更新日期:2019-03-01 00:00:00

  • Diagnostic value of glypican-3 in alpha fetoprotein negative hepatocellular carcinoma patients.

    abstract:BACKGROUND:The prognosis of patients with hepatocellular carcinoma(HCC) is generally very poor with a 5-year survival rate of less than 15% since most of them are diagnosed clinically at their late stage. However, the differential diagnosis between alpha fetoprotein(AFP) negative HCC and cirrhotic nodules is still diff...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i3.26

    authors: Li B,Liu H,Shang HW,Li P,Li N,Ding HG

    更新日期:2013-09-01 00:00:00

  • Maternal nutrition: how is Eastern and Southern Africa faring and what needs to be done?

    abstract:BACKGROUND:The progress in key maternal health indicators in the Eastern and Southern Africa Region (ESAR) over the past two decades has been slow. OBJECTIVE:This paper analyzed available information on nutrition programs and nutrition-specific interventions targeting maternal nutrition in the ESAR and proposes steps ...

    journal_title:African health sciences

    pub_type: 杂志文章,meta分析

    doi:10.4314/ahs.v15i2.28

    authors: Salam RA,Syed B,Syed S,Das JK,Zagre NM,Rayco-Solon P,Bhutta ZA

    更新日期:2015-06-01 00:00:00

  • Neurosyphilis masquerading as hemiparesis and Jacksonian epilepsy in an HIV positive patient: a case report.

    abstract:BACKGROUND:Neurosyphilis is a common but often missed disease worldwide, mainly because it has many manifestations making its diagnosis difficult. It is often missed among HIV patients as the search for other co-infections such as toxoplasmosis often overshadows its consideration. OBJECTIVES:To describe one of our cas...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Kyebambe PS

    更新日期:2010-06-01 00:00:00

  • Mandibular reconstruction with autogenous non-vascularised bone graft.

    abstract:Background:Reconstruction of mandibular defects can be challenging because an acceptable aesthetic and functional outcome must be achieved simultaneously. Aim:To evaluate the pattern of mandibulectomy and reconstruction materials used in the reconstruction of mandibular defects. Materials and methods:This was a retro...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i3.53

    authors: Braimah RO,Ibikunle AA,Abubakar U,Taiwo AO,Oboirien M,Adejobi FA,Ndubuisi TG,Abubakar S

    更新日期:2019-09-01 00:00:00

  • Diagnostic utility of clinical and biochemical parameters in pancreatic head malignancy patients with normal carbohydrate antigen 19-9 levels.

    abstract:BACKGROUND:Carbohydrate antigen (CA)19-9 that is the most widely used biomarker for pancreatic cancer has certain limitations in diagnosis, which results in a tough job to distinguish pancreatic cancer from benign tumors with normal CA19-9. The aim of this study was to investigate the diagnostic utility of clinical par...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v15i1.17

    authors: Jin X,Wu Y

    更新日期:2015-03-01 00:00:00

  • Serum zinc levels in hospitalized children with acute lower respiratory infections in the north-central region of Nigeria.

    abstract:BACKGROUND:Macronutrient deficiency has continued to attract significant research interest, where as the import of micronutrients like zinc has only recently become the focus of interest. Thus against the background of a dearth of data on zinc levels in Nigerian children with Acute Lower Respiratory Infection (ALRI), t...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v14i1.21

    authors: Ibraheem RM,Johnson AB,Abdulkarim AA,Biliaminu SA

    更新日期:2014-03-01 00:00:00

  • Influence of indoor formaldehyde pollution on respiratory system health in the urban area of Shenyang, China.

    abstract:BACKGROUND:The decoration of interior spaces can lead to dangerous levels of indoor formaldehyde pollution. Exposure to indoor air pollution may be responsible for nearly 2 million deaths per year in developing countries. OBJECTIVES:To assess the prevalence of indoor formaldehyde pollution caused by decoration and res...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i1.19

    authors: Zhai L,Zhao J,Xu B,Deng Y,Xu Z

    更新日期:2013-03-01 00:00:00

  • The utility of the Helicobacter pylori stool antigen test in managing dyspepsia: an experience from a low resource setting.

    abstract:BACKGROUND:Dyspepsia is defined as a chronic or recurrent pain or discomfort centered in the upper abdomen. Endoscopy is the best strategy for confirming the cause of dyspepsia. Non- invasive strategies would be more appropriate in low resource countries where endoscopy is not readily available. However, there is conce...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v14i4.9

    authors: Segamwenge IL,Kagimu M,Ocama P,Opio K

    更新日期:2014-12-01 00:00:00

  • Gender-based profiling of Quality of Life (QOL) of primary health care (PHC) attendees in central Uganda: a cross sectional analysis.

    abstract:OBJECTIVE:To analyze gender differences in QOL of patients presenting at PHC centres and to identify the socio-demographic variables associated with poor QOL. METHODS:This was a cross-sectional study. Consecutive adult patients at outpatient departments of three PHC centres were eligible. Those selected were interview...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Muhwezi WW,Okello ES,Turiho AK

    更新日期:2010-12-01 00:00:00

  • Prevalence and antibiotic susceptibility pattern of bacteriuria among HIV-seropositive patients attending the Bamenda Regional Hospital, Cameroon.

    abstract:Background:HIV causes a decrease in CD4+ lymphocyte cells count, exposing the individual to infections (urinary tract infections). This study was carried out to determine the prevalence of bacteriuria and antimicrobial susceptibility pattern of bacteria isolates among HIV patients. Methods:Clean catch mid-stream urine...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i3.7

    authors: Samje M,Yongwa O,Enekegbe AM,Njoya S

    更新日期:2020-09-01 00:00:00

  • Sea-change or change challenge? Health information access in developing countries: The U.S. National Library of Medicine experience.

    abstract::Health professionals in developing countries want access to information to help them make changes in health care and contribute to medical research. However, they face challenges of technology limitations, lack of training, and, on the village level, culture and language. This report focuses on the U.S. National Libra...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Royall J,Lyon B

    更新日期:2011-09-01 00:00:00

  • Effect of tramadol addiction alone and its co-abuse with cannabis on urinary excretion of Copper, Zinc, and Calcium among Egyptian addicts.

    abstract:Background:The use of illicit drugs has become a worldwide health problem. Substances with the potential to be abused may have direct or indirect effects on physiologic mechanisms that lead to organ system dysfunction and diseases. Objective:The present study aims to investigate the structural and reabsorption integri...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v18i3.35

    authors: El-Safty I,Eltamany E,Shouman A,El-Gamel O,Nada A,Ali W

    更新日期:2018-09-01 00:00:00

  • The in vitro antimicrobial activity of fruit and leaf crude extracts of Momordica charantia: a Tanzania medicinal plant.

    abstract:OBJECTIVE:To evaluate the antimicrobial activity of Momordica charantia extracts on reference strains and microorganisms isolated from clinical specimens. METHOD:Petroleum ether and methanolic crude extracts of fruits and leaves of the plant were evaluated for antimicrobial activity using the disk diffusion method on ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Mwambete KD

    更新日期:2009-03-01 00:00:00

  • Secular trend of the leading causes of death in China from 2003 to 2013.

    abstract:BACKGROUND:To analyze the epidemiological characteristics and secular trends of the leading causes of death in China. METHODS:Data on the leading causes of death was collected from the Statistical Yearbook of China. Data for 11 years, from 2003 to 2013, was analyzed by regression analysis and chi-square test. RESULTS...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i2.29

    authors: Ren Y,Zhang M,Luo X,Zhao J,Yin L,Pang C,Feng T,Wang S,Wang B,Zhang H,Yang X,Hu D

    更新日期:2017-06-01 00:00:00

  • QTc prolongation in Black diabetic subjects with cardiac autonomic neuropathy.

    abstract:Background:Prolonged corrected QT (QTc) has been identified as a risk factor for malignant arrhythmias and sudden cardiac death. Caucasian studies have shown a definite relationship between QTc prolongation and Cardiac Autonomic Neuropathy (CAN) in diabetic subjects. Objective:To determine the prevalence of prolonged ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i4.17

    authors: Ukpabi OJ,Onwubere BJ

    更新日期:2017-12-01 00:00:00

  • Nutritional update: relevance to maternal and child health in East Africa.

    abstract::In this review of recent advances in nutrition, we shall follow the 'life cycle' with special attention to maternal and foetal nutrition, linear growth, and nutritional assessment. We also consider nutrition, infection and micronutrients, and recent concepts of the pathophysiology and management of protein energy maln...

    journal_title:African health sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Duggan MB

    更新日期:2003-12-01 00:00:00

  • Ocular injuries and eye care seeking patterns following injuries among cocoa farmers in Ghana.

    abstract:BACKGROUND:The work environment of cocoa farmers exposes them to several ocular hazards that predispose them to eye diseases and injuries. However, the extent of ocular injuries and health seeking patterns following these injuries are unknown among cocoa farmers in Ghana. OBJECTIVES:To determine the prevalence of ocul...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v16i1.34

    authors: Bert BK,Rekha H,Percy MK

    更新日期:2016-03-01 00:00:00

  • Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria.

    abstract:Background:The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women a...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v18i3.15

    authors: Oladosu-Olayiwola O,Olawumi H,Babatunde A,Ijaiya M,Durotoye I,Biliaminu S,Ibraheem R

    更新日期:2018-09-01 00:00:00

  • Empty sella syndrome: incidental findings at computerised tomography.

    abstract::A case is presented of a 43-year-old female patient who presented with severe dizziness, neck pain and headache. Clinical examination revealed diplopia with a horizontal gaze. Plain skull radiographs showed an enlarged sella turcica with no abnormal intracraial calcifications. Pre and post contrast axial and post cont...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Luutu I

    更新日期:2001-08-01 00:00:00

  • Pattern of eye diseases among welders in a Nigeria community.

    abstract:BACKGROUND:Welders have been identified as a high risk group for eye disorders due to their exposure to ultraviolet radiation. OBJECTIVE:To determine the prevalence and types of eye diseases amongst welders in Ile-Ife, Osun state. METHODS:This is a cross sectional descriptive study of 405 consenting welders. Informat...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v12i2.21

    authors: Ajayi Iyiade A,Omotoye Olusola J

    更新日期:2012-06-01 00:00:00

  • Salivary flow, amylase, and total protein in hospitalized patients with HIV infection / AIDS complications.

    abstract:Background:Saliva is a complex secretion produced daily by the salivary glands. Saliva consists mainly of water, enzymes, ions and amino acids and performs several important functions in oral health. Objective:The aim of this study was to investigate the flow rate and concentrations of amylase and total proteins in th...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i2.7

    authors: de Oliveira NC,de Oliveira TC,Klamas VC,Ventura MA,Kamei AA,Naka JY,Brancher JA,de Lima AAS

    更新日期:2020-06-01 00:00:00

  • Endometriosis of the appendix.

    abstract::Endometriosis is a well known cause of infertility. Endometriosis of the appendix is a very rare condition. To highlight this rare entity, we are reporting a case of a young lady who was admitted with recurrent attacks of lower abdominal pain associated with primary infertility. Preoperative diagnosis was acute append...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Al Oulaqi NS,Hefny AF,Joshi S,Salim K,Abu-Zidan FM

    更新日期:2008-09-01 00:00:00