Abstract:
BACKGROUND:Cholera, a severe acute watery diarrhea caused by Vibrio cholerae is endemic in Nigeria with most cases occurring in the rural areas. In South West Nigeria, some individuals resort to alternative treatments such as Ogi-tutu, Psidium guajava and Vernonia amygdalina during infections. The effectiveness of these alternatives in the prevention and treatment of V. cholerae infection requires experimental investigation. OBJECTIVE:This study was designed to investigate the ameliorative effects of Ogi-tutu, Vernonia amygdalina and Psidium guajava on intestinal histopathology of experimental mice infected with V. cholerae. METHODS:Preliminary investigation of in vitro vibriocidal activities of these alternatives were carried out using agar cup diffusion assay. For ameliorative effects, adult mice were inoculated with 100 µl (106 cells) of Vibrio cholerae and dosed at 0 h (immediate prevention) and 4 h (treatment of infection) and their intestines were histopathologically evaluated. RESULTS:The histopathological changes were the same irrespective of the treated groups, but the lesions varied in extent and severity. The ameliorative effects in decreasing order were V. amygdalina > P. guajava > Ogi-tutu. CONCLUSION:V. amygdalina gave the best ameliorative effects in the prevention and treatment of V. cholerae infection.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Shittu OB,Ajayi OL,Bankole SO,Popoola TOdoi
10.4314/ahs.v16i2.33subject
Has Abstractpub_date
2016-06-01 00:00:00pages
620-8issue
2eissn
1680-6905issn
1729-0503pii
jAFHS.v16.i2.pg620journal_volume
16pub_type
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