Abstract：
BACKGROUND:The prognosis of patients with hepatocellular carcinoma(HCC) is generally very poor with a 5-year survival rate of less than 15% since most of them are diagnosed clinically at their late stage. However, the differential diagnosis between alpha fetoprotein(AFP) negative HCC and cirrhotic nodules is still difficult. OBJECTIVES:To evaluate the diagnostic value of glypican-3(GPC3) in patients with AFP negative hepatitis B related HCC. METHODS:The liver tissue GPC3 (GPC3L) expression was tested from 426 for surgery and 179 of needle biopsies of hepatitis B related HCC patients using immunohistochemistry staining. Serum GPC3 (GPC3S) and AFP were also measured. RESULTS:Among surgical HCC samples, 80.0% of GPC3L expression was positive, however, in paracarcinomatous and cirrhotic nodules were negative. In needle biopsy tissues, GPC3L positively expression was in 74.9%. The sensitivity of AFP>400 µg/L was 25.4%. The GPC3S >3.5 µg/L was determined as a positive. The area of ROC curve of GPC3S was 0.68(95% CI 0.56-0.79,P<0.05) in all HCC patients,0.81 (95% CI 0.62 -0. 98, P<0.05) in AFP greater or equal to 400 µg/L and 0.64 (95% CI 0.51-0.77, P=0.051) in AFP negative patients. The GPC3S was positive in 48.8% of patients with AFP negative. No difference was observed between GPC3L/GPC3S and serum AFP. CONCLUSIONS:GPC3 may be helpful in improving diagnosis of HCC and in differentiating diagnosis between AFP negative HCC and cirrhotic nodules.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Li B,Liu H,Shang HW,Li P,Li N,Ding HGdoi
10.4314/ahs.v13i3.26subject
Has Abstractpub_date
2013-09-01 00:00:00pages
703-9issue
3eissn
1680-6905issn
1729-0503pii
jAFHS.v13.i3.pg703journal_volume
13pub_type
杂志文章abstract：Background:The use of illicit drugs has become a worldwide health problem. Substances with the potential to be abused may have direct or indirect effects on physiologic mechanisms that lead to organ system dysfunction and diseases. Objective:The present study aims to investigate the structural and reabsorption integri...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v18i3.35
更新日期：2018-09-01 00:00:00
abstract：Background:Reconstruction of mandibular defects can be challenging because an acceptable aesthetic and functional outcome must be achieved simultaneously. Aim:To evaluate the pattern of mandibulectomy and reconstruction materials used in the reconstruction of mandibular defects. Materials and methods:This was a retro...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v19i3.53
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:The study was performed to investigate the association of interleukin 17 (IL 17) or angiotensin II (Ang II) with refractory hypertension risk in hemodialysis patients. METHODS:Ninety hemodialysis patients were enrolled into this study, and those with hypertension were divided into two groups. The Easy-to-Con...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v16i3.17
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Reduction in renal length was found to be an insufficient independent indicator of chronic renal disease. OBJECTIVE:To determine the ultrasound normative values of renal parenchymal thickness (RPT) among adults and correlate them with age and somatometric parameters. METHODS:This was a prospective clinic b...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v14i3.27
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Standardised measuring instruments are increasingly used in psychiatric research cross-culturally. These instruments are considered to be culturally equivalent when all forms of biases, or social norms specific to the culture of origin, have been removed. OBJECTIVES:To describe the qualitative process of se...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.5555/afhs.2006.6.4.215
更新日期：2006-12-01 00:00:00
abstract：Background:The integrated approach to malaria prevention, which advocates for the use of several malaria prevention methods at households, is being explored to complement other existing strategies. We implemented a pilot project that promoted the integrated approach to malaria prevention in two rural communities in Wak...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v18i4.35
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Neurosyphilis is a common but often missed disease worldwide, mainly because it has many manifestations making its diagnosis difficult. It is often missed among HIV patients as the search for other co-infections such as toxoplasmosis often overshadows its consideration. OBJECTIVES:To describe one of our cas...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：Background:Rape remains a controversial issue with a few victims reporting experience because of the myriad of societal perception, prolonged steps in pursuing a case to logical conclusion of securing conviction, as well as psychological and physical residuals of the experience. Data in Nigeria is therefore hard to com...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v20i2.17
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Mistakes in the identification and administration of drugs may be fatal. This is especially so in the practice of anaesthesia. This is a report of 2 cases of near fatality due to mistakes in drug administration from look-alike medications. OBJECTIVE:To highlight the significance of medication errors in our ...
journal_title：African health sciences
pub_type： 杂志文章,评审
doi：10.4314/ahs.v13i3.46
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Accuracy of some ultrasound equations used in our locality for fetal weight estimation is doubtful. OBJECTIVE:To assess the accuracy of common ultrasound equations used for fetal weight estimation. SUBJECTS AND METHODS:A longitudinal study was conducted on selected Nigerian obstetric population at Central ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v15i1.27
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus (DM) and essential hypertension are chronic medical conditions that place a lot of burden on patients. The presence of depression and suicidal behaviour may worsen the prognosis. OBJECTIVE:To assess the prevalence of depression and suicidal behaviour in subjects with diabetes mellitus and ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v13i1.10
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:The concept of pharmaceutical care is neither well developed nor adequately documented in Uganda. OBJECTIVES:This study is therefore an attempt to identify and quantify the various service components of community pharmacy practice in Kampala, Uganda's capital city. SETTING:Two pharmacies operating retail o...
journal_title：African health sciences
pub_type： 杂志文章,多中心研究
doi：
更新日期：2003-08-01 00:00:00
abstract：Background:Elabela (ELA) is a hormone that is secreted at high levels in the kidneys of a healthy adult. This study aims to investigate whether serum ELA levels of patients with Type 2 Diabetes vary with the severity of renal damage. Methods:Our study included 50 healthy control subjects and 100 diabetic patients, who...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v20i2.37
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Falls are a major cause of disability, morbidity and mortality in older persons, but have been under researched in developing countries. OBJECTIVE:To describe challenges encountered in a community-based study on falls in a multi-ethnic population aged ≥65 years in a low-income setting. METHODS:The study wa...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v17i3.35
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The morbid effects of urinary bilharziasis are becoming more evident with the advent of sophisticated diagnostics such as ultrasound. However, such diagnosis of Schistosoma haematobium morbidity is often hampered by lack of funds, proper equipment, or training. OBJECTIVE:We performed a cross-sectional inves...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:We determined the genetic diversity of mycobacteria isolated from tuberculosis patients in Mbarara Uganda, using region of difference (RD) analysis and spacer oligonucleotide typing (spoligotyping). METHODS:Sputum samples were cultured on Lowenstein Jensen media. The isolates were characterized using RD ana...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：Background:Variceal upper gastrointestinal bleeding (UGIB) is common in sub-Saharan Africa (SSA). However, poor access to endoscopy services precludes the diagnosis of varices. Objectives:We determined the diagnostic accuracy of routine clinical findings for detection of esophageal varices among patients with UGIB in ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v19i4.46
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Resistance to most antimalarial drugs has encouraged the use of herbal preparations along with prescribed orthodox drugs. OBJECTIVE:To investigate effect of co-administration of aqueous extract of T. occidentalis leaves; commonly used as antimalarial and haematinic agent in Nigeria and artesunate using P. b...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v13i4.16
更新日期：2013-12-01 00:00:00
abstract：:Efforts to introduce and integrate the discipline of family medicine in sub-Saharan Africa have remained slow due to failure to understand what role and benefit such physicians can play in the existing health care systems in the region. An attempt is made here to explain reasons for this trend and suggest ways to over...
journal_title：African health sciences
pub_type： 信件
doi：10.5555/afhs.2007.7.2.120
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Pulmonary hydatid cysts are caused by larval forms of the tapeworm Echinococcus granulosus. Hydatid disease, which is endemic in Turkey, is an important health problem in agricultural and stockbreeding areas where there are insufficient environmental health and preventive medicine services. Previous studies ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v11i3.70075
更新日期：2011-08-01 00:00:00
abstract：Background:Propofol is administered as intermittent boluses to achieve deep sedation to facilitate oesophagogastroduodenoscopy. Target controlled infusion (TCI) can be employed for this purpose. Methods:176 adults were randomly allocated into two groups of 88 patients. Control group: Received an initial bolus of propo...
journal_title：African health sciences
pub_type： 杂志文章,随机对照试验
doi：10.4314/ahs.v19i4.36
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Thrombocytopenia has been shown to predict mortality. We hypothesize that platelet indices may be more useful prognostic indicators. Our study subjects were children one month to 14 years old admitted to our hospital. AIM:To determine whether platelet count, plateletcrit (PCT), mean platelet volume (MPV) an...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v16i2.3
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Unconsummated marriage is a problem among couples who would not be able to perform natural sexual intercourse and vaginal penetration. This disorder is more common in developing countries and sometimes couples would come up with non-technical and non-scientific methods to overcome their problem. Multi-dimens...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v17i3.5
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Non-traumatic perforation of the small bowel is an uncommon serious complication associated with high morbidity and mortality. Diseases that cause small bowel perforation vary in different areas of the world. OBJECTIVE:To highlight difficulties in the diagnosis and management of non-traumatic perforation of...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVES:To investigate the pattern of referral for and utilisation of physiotherapy in the continuum of stroke care at a tertiary hospital in Ibadan, Nigeria. METHODS:Referral notes and medical records of patients admitted in the University College Hospital, Ibadan with a clinical diagnosis of stroke between Januar...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v17i1.11
更新日期：2017-03-01 00:00:00
abstract：INTRODUCTION:Hysterosalpingography (HSG) is still a commonly used investigation in the evaluation of the female genital tract and the main indication for HSG is infertility. OBJECTIVE:The purpose of this study was to find the pathology detected at HSG in patients with infertility in our setting. MATERIALS AND METHODS...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Due to increasing stress, individual personality traits are becoming a significant contributor to CRT (Crash Related Trauma). In the present study, we hypothesized that there will be no difference in personality characteristics of CRT patients and control subjects and there will be no association between tra...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v16i3.27
更新日期：2016-09-01 00:00:00
abstract：Background:Surgical site infections (SSI) are a potential cause of morbidity and increased cost of care after operations such as open prostatectomy. Objective:To audit the occurrence of SSI after open prostatectomy at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria. Methods:A revi...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v19i2.30
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The diagnosis of tuberculosis in children is difficult particularly in HIV infected children. The poor outcome following antituberculosis treatment usually reported in HIV infected children might be due, in part, to other HIV-related chronic diseases wrongly diagnosed as TB. OBJECTIVE:The study examines the...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:This study is the first documented prevalence of IgG antibody against HSV-1&-2 in Port Harcourt, Nigeria and thus provides baseline data for future in-depth studies on HSV infection in South-South, Nigeria. OBJECTIVE:This study determined the seropositivity and determinants of serum IgG antibody against HSV...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v15i3.6
更新日期：2015-09-01 00:00:00
